"Congratulations on lending 500,000 yuan, and customers can’t keep up." Xiao Bo (a pseudonym), who claimed to be an intelligent outbound service provider for telemarketing, updated his circle of friends with a screenshot of a customer’s successful lending. In Xiao Bo’s circle of friends, there are many similar "success stories". Xiao Bo claims that his telemarketing robot can make more than 1,000 calls in a single day, and the connection rate remains at 30% or even higher, and can avoid supervision and prevent titles.

Are you still bothered by harassing calls about selling loans and POS machines?

From late October to November, 2021, The Paper reporter found that the chaos in the telemarketing industry still exists. The technical model of "outbound call system+telemarketing robot" claims to be able to accurately dial the special line and mark the customer information, and evade the supervision of communication operators through technology; Behind it are hidden behaviors such as illegal trading of personal information and illegal sales of POS machines.

The so-called "anti-sealing" call-out system for electric sales

Telemarketing is a sales method relying on telephone, which contacts customers through special telephone marketing numbers to complete product promotion, quotation, transaction, etc., but this method is often easy to cause harassment to users. In the media reports, there are many cases in which telephone users are often disturbed by receiving telemarketing calls. In recent years, the Ministry of Industry and Information Technology and the three major operators have taken measures such as "high-frequency call blocking". However, with the application of intelligent voice and other technologies, the intelligent outbound calling software system, which claims to be able to make a large number of calls a day and "prevent blocking" (prevent blocking), still makes users hard to prevent.

A recent survey in The Paper found that some telemarketing software used "anti-sealing" as a gimmick to attract customers, and all kinds of "anti-sealing robots" gradually became popular in the market.

In Baidu Post Bar and Tencent QQ, the keyword "electricity sales" is searched, which shows a lot of information about "electricity sales software". The reporter randomly joined a QQ group named "Outbound Call System for Telemarketing", with more than 1,000 members and an account named "Chamber of Commerce for Telemarketing Systems" posting various promotional information related to Telemarketing from time to time in the group. "electricity sales card", "electricity sales App" and "electricity sales anti-sealing system" ……

The sales information in the group claims that the services provided can cover the whole industry such as finance, collection, loan, insurance, health care, drinks, auto insurance and games.

The reporter randomly added the WeChat of Xiao Bo, a telemarketing intelligent outbound service provider, from the QQ group. He asked the reporter what business he wanted to do, saying, "Let’s see if we can do it. Now the telecom fraud investigation is strict." After confirming that it was a "campus loan" business, he enthusiastically introduced his products and sent a price list, including a set of real-life speech made by 300 yuan, and a robot package divided into basic version, premium version and agent version according to different price points and specifications. During the conversation, Xiao Bo said that most of his clients are selling financial stocks, loan insurance and POS machine sales, all of which can be "sealed".

In his description, the "anti-sealing robot" does not need any calling cards and auxiliary equipment, and the outbound call system purchased together will use the group call line to dial the number. Regarding the reporter’s question that "making too many calls will not be seized", Xiao Bo replied that a certain line will inevitably have complaints every month, but as long as it reaches the upper limit of the complaint rate, it will stop the line and replace it with another one, so as to prevent the system purchased by customers from being blocked. He also mentioned a new business to be launched soon-an anti-sealing App for electricity sales. In the promotional picture of the App, the words "the three major operators’ Puka seconds turn white list and the high frequency does not seal the number" are placed in the most conspicuous position.

In order to further dispel the reporter’s doubts, Xiao Bo added, "We are first-class landing line operators and all cooperate with operators."

He Zheng (a pseudonym), another service provider who claimed to be engaged in the research and development of the telemarketing system for 6 years, explained to reporters that the telemarketing robot business on the market now basically adopts the "line+system+service" model. Buyers only need to use the account they provide, and they can enjoy a full set of services, "including technical support, carrying lines and after-sales."

In the 1 minute and 22 second recording of "Loan Talk" he sent, a customer on the other end of the phone in love women, who claimed to be a "customer service representative of a bank", indicated that he could handle a loan of 3-5 million yuan and "pay it back as you borrow it". In this conversation, the customer service representative repeatedly said that he was a staff member of "a bank credit center" and asked about the occupation of the telemarketing customer, the loan and insurance business he handled, and "whether there is a house or a car under his name".

He Zheng said that the so-called "bank customer service representative" bought their telemarketing system, recorded it in advance, and combined it into a complete sales talk according to the matching of the system. The customer thought it was a real person and was constantly "promoted", and might place a loan order. But in fact, they don’t know whether this "bank customer service representative" is a bank staff member or a telecom fraudster.

The "material dealer" in the dark of the electricity sales industry

In the telemarketing industry, an important part is to obtain customer information resources. The illegal trading of personal information also breeds in the dark.

After the reporter joined a QQ group, a "supplier" who claimed to specialize in health care lines (the person who provided information such as the user’s phone number) sent a message in the QQ group saying that he obtained the information of consumers who bought a health care book in TV shopping programs and then sold it to the telemarketing team or system service provider who promoted health care products. In the screenshots he sent, these consumers are distributed in different provinces such as Shandong, Henan and Zhejiang.

Compared with system service providers, "material suppliers" are more cautious. They usually don’t directly give contact information such as WeChat or telephone, and they will communicate further after confirming that the other party is an "intended customer".

In a chat with a "supplier" named AZY, the reporter learned that most customer resources are divided into "AI materials" and "hand-stripping materials". "AI material" is provided for electric sales robots, while "hand stripping material" is provided for employees who make phone calls manually. According to the feedback rate of dialing, the prices of the two "materials" are also different. Generally speaking, the feedback rate of "hand stripping" is higher than that of "AI material" and therefore the price is higher.

According to the price standard sent by AZY, 600 yuan RMB can buy 10,000 pieces of AI materials or 1,000 pieces of user information. These materials are usually replaced by different pinyin abbreviations, such as the special line for investors, which they call "GM powder", and the online loan, which is called "Wd".

There are many "anti-pit and anti-second-hand material merchants" posts in Baidu Post Bar. Some familiar "material merchants" will add WeChat to each other and set up their own WeChat groups, in order to expand or stabilize their sources of "materials".

In the investigation, the reporter found that in order to be more concealed, the transactions between suppliers and buyers often shift from WeChat to other more private online trading platforms. The line operator "AXY" chose an overseas chat software called "Telegram" to complete the transaction with the customer. After failing to reach a transaction with the reporter, "AXY" immediately closed his QQ space.

How to deal with the chaos of electricity sales

In recent years, the phenomenon of electricity sales has been repeatedly concerned and rectified.

In 2019, the central bank issued document [2019] No.85 "Notice of the People’s Bank of China on Further Strengthening the Management of Payment and Settlement to Prevent New Crimes in Telecommunication Networks", pointing to the chaos of telephone sales of POS machines. At the same time, a number of payment institutions issued a notice on strictly prohibiting online sales and electronic sales of POS machines. However, the circle of friends of service provider He Zheng is still full of sales records of a large number of "POS machine" sales customers. When the reporter asked about the POS machine sales business, he did not show him any business license in the financial industry.

According to media reports, the sales scam of POS machines has already become a high-incidence area for complaints. Telephone sales mostly attract customers to use their products with "low rate and free delivery", but after the user places an order, there will be various charges including activation fee, deposit, service fee and so on. The reporter’s search on the Internet also found that many deceived users reported that they could not get the account after receiving the POS machine, and even were blacked out directly by the salesman.

In May this year, the Consumer Protection Bureau of China Banking and Insurance Regulatory Commission issued Circular No.8 of 2021, "Circular on Cases of Ping An Bank’s Telemarketing of Physical Products Infringed on Consumers’ Legal Rights and Interests" (hereinafter referred to as "Circular"), which informed the case that Ping An Bank cooperated with a third party to sell physical products by telephone and infringed on consumers’ legal rights and interests.

According to the "Circular", in the spot check of 60 physical products sold by Ping An Bank Credit Card Center, 53 businesses were illegal, accounting for 88.33%.

Fu Liang, a telecom analyst, told The Paper that at present, the management of the domestic electricity sales industry has not yet formed a complete norm. "Many links have not been (completely) opened." If the management standards between relevant departments cannot be unified, there will be barriers to the management and rectification of the chaos of electricity sales. Even if users find their personal information leaked or traded, it is often difficult to find a "channel" for complaints and handling.

Fu Liang also pointed out that operators are the primary link to ensure that users’ information is not leaked. They often have their own strict operating norms, but they cannot completely avoid the possibility of leaks in huge business branches. Moreover, in this highly developed network era, many personal information is in a "semi-public" state.

He believes that in the use of various scenes in daily life, such as telephone numbers and names, information is constantly used and exchanged, and it is difficult to completely quantify whether it involves "privacy disclosure". "If there is an improper transaction of user information, no matter where it happens, it is an illegal act."

　　Knowing the news of Huang Xing’s death, Yang Chengrong, a poor household who was nearly 80 years old, burst into tears: "He is a relative of our poor household!"

　　Huang Xing, deputy director of Shiyan Poverty Alleviation Office, Hubei Province. On February 28th this year, 46-year-old Huang Xing suffered a sudden myocardial infarction after working for several days in a row. He died in the line of duty and fell on the road to poverty alleviation. Recently, the Hubei Provincial Federation of Trade Unions posthumously awarded Huang Xing the Hubei May 1 Labor Medal and called on the majority of trade union cadres to learn from it.

　　I broke down from overwork and had a heart attack. I went to the hospital with a poverty alleviation manual.

　　Shiyan Poverty Alleviation Office, Office 4128. The large-scale schematic diagram of the Ten Commandments’ accurate poverty alleviation is still hung in a prominent position on the wall, but it can’t wait to draw its owner.

　　"He misses the poverty alleviation work every day and always refuses to let himself take a short rest. This time he can finally rest." Xu Hongbo, the chief of general department in the same office as Huang Xing, wiped away tears and said.

　　In the last 59 days of his life, except for the four-day holiday of the Spring Festival, Huang Xing has been running in the front line of poverty alleviation, including 23 days in northern Shaanxi to participate in the inter-provincial cross-examination of national poverty alleviation and development.

　　"In northern Shaanxi, there is ice and snow everywhere, and it is about MINUS 20 degrees Celsius outside. Huang Xing enters the village during the day, and he has to work overtime after the group meeting at night, often after 2 am." Zhang Guangming, deputy director of the Poverty Alleviation Office in Maojian District, Shiyan City, Hubei Province, who participated in the assessment with Huang Xing, said that as the deputy head of the assessment team, Huang Xing was not only responsible for routine work, but also responsible for overall planning and summary, which was more arduous than the work of the team members.

　　Returning to Shiyan from Shaanxi, Huang Xing neglected to rest and continued to work overtime.

　　"On February 26, two days before his illness, he was still supervising the poverty alleviation assessment in danjiangkou city." Xu Hongbo recalled that on February 27th, Huang Xing came to the office early and worked overtime until about 11 o’clock that evening. Suddenly, he said that his heart was uncomfortable, and Xu Hongbo and his colleagues rushed him to the hospital.

　　When he went to the hospital, he still had a poverty alleviation manual in his pocket. Xu Hongbo said that in the last few hours of his life, Huang Xing was still asking the doctor: "Can you give me some medicine? I want to go back to work early."

　　Due to his serious illness, Huang Xing was still unable to recover his vital signs after being rescued in the intensive care unit for more than 10 hours. He died at noon on February 28th at the age of 46. His family left only his 80-year-old frail mother and his daughter who was in the first year of high school.

　　Take things in the village as your own business.

　　Daping Village, Maota Township, Maojian District, Shiyan City is the designated contact village of Shiyan Poverty Alleviation Office. As the backbone of the Poverty Alleviation Office, Huang Xing is a frequent visitor in the village.

　　In the diary, Huang Xing once wrote: "Always remember that I am a party member who serves the people and treats the poor people with sincerity. No matter how busy you are, you can’t forget the poor households! "

　　But after all, he didn’t wait until Daping Village got rid of poverty.

　　As one of the 456 poverty-stricken villages in Shiyan City, after three years of poverty alleviation, only 54 households in Daping Village are still out of poverty. According to the plan, the whole village will be listed at the end of this year.

　　"Without Director Huang, how can we get rid of poverty in our village so smoothly? Our whole village remembers his kindness. " Liu Qinglong, secretary of the Party branch of Daping Village, said that Huang Xing took things in the village as his own business. In late January this year, heavy snow fell in Shiyan, and the greenhouse vegetables in the village were seriously affected. On the day he returned from a business trip in Shaanxi, Huang Xing rushed to the village to discuss disaster relief measures.

　　"I heard that Director Huang died, and I didn’t sleep a wink all night. Such a good person, how can God let him go! " Standing in front of his new house, Liu Tiane, a poor household, was tearful.

　　In 2015, Liu Tianqi’s husband died of illness. She had to raise children and pay her husband more than 100,000 yuan in medical debts, which made the originally poor family worse. Huang Xing took the initiative to find the door and formed a helping pair with her to help her find the right thing to do and improve her housing conditions according to relevant policies.

　　"Making friends with poor families, helping poor households and uprooting poor roots" is an important measure for Shiyan City to promote precision poverty alleviation and precision poverty alleviation. Yang Chengrong, Yu Shiyou, Wang Demei, etc. are all poor households that Huang Xing "married" in the village. Hearing the bad news, they all said it was hard to accept.

　　There are more "relatives" in poor households, and Huang Xing has less time to spend with his family and children, but his family understands this very well.

　　After his death, his 15-year-old daughter wrote: "Dad is a conscientious and meticulous person who treats his work and treats his colleagues kindly. Meticulous to me and grandma. He is my hero … …” His old mother is a retired teacher. When talking about her son, the old man said with tears: "He gave his life to the party and the people. He is glorious!"

　　He is not only working hard, but also an expert in theory.

　　According to Peng Wenjun, director of Shiyan Poverty Alleviation Office, Huang Xing is an "old ox" on the road to poverty alleviation.

　　"He has to deal with daily affairs during the day, and he has to stay up late to write various documents when he goes home at night. There is always endless work." Peng Wenjun said.

　　"He had the opportunity to transfer to other positions in the province or the city, but he declined them one by one. He said that it is a critical moment to get rid of poverty and he must not be a deserter!" Peng Wenjun said.

　　What makes colleagues admire even more is that Huang Xing is not only working hard, but also an expert in theory.

　　Having worked for 25 years, Huang Xing has been in the poverty relief office for 22 years, and has been rated as an excellent civil servant for three consecutive years, and has been transferred to the national and provincial poverty relief offices for special work many times. He wrote or participated in the drafting of the Plan for Regional Development and Poverty Alleviation in Qinba Mountain Area (2011— In 2020), the Implementation Plan for Regional Development and Poverty Alleviation in Qinba Mountain Area of Hubei Province and the Decision of Hubei Province on Further Strengthening Poverty Alleviation and Development are also well-known in the poverty alleviation system.

　　Peng Wenjun introduced that Huang Xing has been responsible for the assessment of precision poverty alleviation for a long time. Since 2014, Shiyan has been rated as excellent for four consecutive years in the assessment of the responsibility system for poverty alleviation work of local party and government in Hubei Province.

　　"How to fight the tough battle against poverty in the city, how to supervise the implementation of policies, how to consolidate and improve the effect of poverty alleviation, etc., we often discuss and plan together." Peng Wenjun said that in the poverty alleviation office, Huang Xing is his "right hand man" and an example in the eyes of his colleagues.

　　After Huang Xing’s death, Shiyan Municipal Committee posthumously awarded him the title of "Excellent Communist party member of the whole city" and called on party member cadres in the whole city to learn from Huang Xing.

　　Zhang Meirong, a colleague of Huang Xing’s before his death, expressed everyone’s voice: "Our generation should carry on the legacy and swear to eradicate poverty!"

【Chexun. com reported】 Recently, the first model of HarmonyOS Zhixing’s last "world" Shangjie H5 was officially released, and the Shangjie synchronization official announced that the new car will be pre-sold on August 25th.

　　For HarmonyOS Zhixing, Shangjie is not only the last link to make it form a "fist power" completely, but also the key to make it burst into greater energy in China auto market. Previously, the photo of Yu Chengdong, managing director of Huawei and chairman of BG, and Jia Jianxu, president of SAIC, driving the Shangjie H5 together triggered a heated discussion on the Internet. This high-level interaction shows that both sides attach great importance to Shangjie H5!

　　Are you ready to challenge the Red Sea and Shangjie H5 in the 200,000-class SUV market? Let’s look down!

　　Large space: accurately fit the mainstream family’s "just need"

　　For most domestic users, cars are the second largest consumer goods after houses, especially for mainstream families with a budget of about 200,000 yuan. "One car with multiple uses" is just needed. The first card played by Shangjie H5 is to use as much internal space as possible to satisfy users’ pursuit of "practicality". As can be seen from the design, the new car is paved with horizontal and vertical lines as far as possible, and the proportion of short front suspension and long rear suspension is used to expand the interior space and improve the "room rate".

　　We can also get evidence from the data of the car body. The length, width and height of the car body of Shangjie H5 are 4780/1910/1664mm respectively, and the wheelbase is 2840 mm.. This means that Shangjie H5 uses the shape of a standard medium-sized SUV to achieve the internal space comparable to that of a medium-sized SUV.

　　The essence of the new car’s space is vividly displayed in the back page. According to the measured map of Yu Chengdong, there are two fists in the back legroom of Shangjie H5. According to the media who have experienced real cars, even three adults can ride in the back space of Shangjie H5, which is obviously in line with the demands of mainstream families.

　　Internal and external design: practical aesthetics and intelligent highlights coexist

　　Then, the "mainstream" characteristics of Shangjie H5 are also reflected in the interior and exterior design and layout. The overall design of the new car looks simple and advanced. Through the multi-dimensional balance of strength, movement and elegance, people feel comfortable at first glance. Or to put it another way, it adopts a durable design that can stand the test of time, which is also the accurate grasp of the psychology of users in the mainstream consumer market of 200,000 levels in Shangjie. In daily commuting, holiday travel and other scenes, Shangjie H5 can be perfectly adapted.

　　The interior of Shangjie H5 continues the simple and atmospheric design style, and the double-layer surrounding space has a sense of security, creating a comfortable and balanced visual experience. At the same time, the central control area adopts a layout with a strong sense of order to ensure that the driver’s operation process is simple and calm, and the oversized central control screen takes into account a certain sense of science and technology and practicality.

　　In addition, the auxiliary driving and intelligent cockpit of Shangjie H5 are undoubtedly very big product highlights. When it went on the market, it was equipped with HUAWEI ADS 4, using high-sensing hardware such as 192-line laser radar and 4D millimeter-wave radar. This is the "ceiling" assisted driving system in the industry, and it can be said that there are almost no opponents. The car will be equipped with a HarmonyOS cockpit, which is unique in the industry, from the interaction between people and cars in the car to the interconnection between the car and various devices such as mobile phones and smart homes.

　　Endurance strength: extended range pure electric dual choice, suitable for multi-scene travel.

　　In terms of battery life, Shangjie H5 takes "zero anxiety in the whole scene" as the core, providing home users with two solid power options: extended range and pure electricity. The extended range version is equipped with a 1.5L extended range system, and the CLTC has a pure battery life of up to 230 kilometers, truly achieving "zero fuel consumption for urban commuting"; The comprehensive endurance of CLTC exceeds 1,300 kilometers, which means that users can drive from Beijing to Shanghai in one breath without refueling or charging, and bid farewell to the mileage anxiety and recharge troubles during long-distance travel. The pure electric version provides 64.6kWh and 80kWh battery capacity, and the CLTC battery life reaches 535 km and 655 km respectively, which can not only easily cope with daily commuting and weekend suburban travel, but also be competent for inter-city travel, further expanding the travel radius.

　　Write at the end:

　　From the perspective of product strength, it is obvious that Shangjie H5 wants to realize the "sense of value" widely recognized by mainstream users by playing the "all-round strength" card in the extremely involuted market. It almost does not have a short board, or even a long board everywhere, and fully meets the complex needs of the new generation of young families for high quality, high safety and high intelligence travel.

　　Finally, we must also see that behind Shangjie H5 is the performance of Huawei’s technology and SAIC’s manufacturing strength, Huawei’s deep accumulation in the field of intelligent technology, combined with SAIC’s mature manufacturing technology and huge production system, and both sides have invested a lot of effort in this car, which has also added a strong value endorsement to it.

　　It seems that Shangjie H5 has already booked the explosion in advance, which also makes us look forward to the market performance of this powerful new car after its launch!

[Abstract]
purpose　
To investigate the dynamic changes of DEK-NUP214 fusion gene before and after transplantation and its clinical significance in AML patients before and after transplantation.
way　
Real-time quantitative polymerase chain reaction (RQ-PCR) and flow cytometry (FCM) were used to detect the DEK-NUP214 gene expression and leukemia-related immunophenotype (LAIP) of 15 newly diagnosed AML patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Peking University People’s Hospital from September 2012 to September 2017.
result
The median follow-up time was 657 days (62-2212 days). The median expression level of DEK-NUP214 was 488.2% (273.6-1692.1%). Thirteen patients had complete remission before allo-HSCT. Among the 15 patients before allo-HSCT, 13 (86.7%) were positive for DEK-NUP214, with a median of 0.32% (0.029-738.9%). Nine patients (69.2%) remained positive for DEK-NUP214 gene after allo-HSCT. However, its expression level decreased by about 500 times (5.7-5,663 times) within one month after transplantation. After transplantation, 5 cases died (33.3%) and 2 cases recurred (13.3%). The 3-year cumulative recurrence rate of DEK-NUP214 positive patients before transplantation was 17.5 11.3%, and the 3-year overall survival rate was 60.5 13.8%. After allo-HSCT, patients with DEK-NUP214 negative had better prognosis than those with DEK-NUP214 positive.
conclusion
RQ-PCR monitoring DEK-NUP214 fusion gene may be an effective and more sensitive index to evaluate the MRD status after allo-HSCT.

[Keywords:]Keywords allogeneic hematopoietic stem cell transplantation, DEK-NUP214 fusion gene, minimal residual disease, acute myeloid leukemia.

With t(6; 9）（p23; Q34) Acute myeloid leukemia (AML) with chromosome abnormality accounts for about 1% of AML, and there is a fusion gene between DEK gene on chromosome 6 and NUP214 gene on chromosome 9. Slovak et al. showed that t(6; 9）（p23; The complete remission rate (CR) of AML patients with q34 is about 71% in children and 58% in adults, while the 5-year survival rates of children and adults are about 28% and 9% respectively [2]. Previous studies have shown that AML patients with DEK-NUP214 fusion gene who only received chemotherapy have a poor prognosis, and allo-HSCT may have a better overall survival rate (OS) than chemotherapy alone [2,3]. Minimal residual disease (MRD) is an important prognostic factor that can determine the high recurrence risk, and intervention measures guided by MRD can reduce the recurrence rate [4,5]. Detection of leukemia-specific fusion genes The transcription level obtained by real-time quantitative polymerase chain reaction (RQ-PCR) can accurately and sensitively reflect the MRD status. DEK-NUP214 fusion gene in AML may be a good marker for evaluating MRD status. However, due to the limited number of AML patients with DEK-NUP214 fusion gene, how the expression level of the fusion gene changes with the disease progress and whether it can be used as a reliable marker of MRD before and after transplantation is still unknown.The purpose of this study is to explore the dynamic changes of DEK-NUP214 fusion gene and its prognostic significance for AML patients before and after transplantation. 　

One,Research objects and methods

1. Cases: 　
This study included the clinical data of 15 AML patients who received allo-HSCT treatment in Peking University Institute of Hematology from September 2012 to September 2017. The widely used WHO standard was used to diagnose patients [6]. Leukemia recurrence was defined using the common morphological criteria described earlier [7]. 　 　
2. Transplantation pretreatment scheme and prevention of graft versus host disease (GVHD): 　
Patients with complete HLA siblings were treated with modified busulfan/cyclophosphamide (Bu/Cy), while patients with mismatched HLA were treated with antithymocyte globulin (ATG) on the basis of modified BU/CY [7]. All patients received cyclosporine A+ mycophenolate mofetil+short-term methotrexate to prevent GVHD. 　 　
3. Specimen collection: 　
Bone marrow samples were collected at initial diagnosis, before transplantation,+30 days,+60 days,+90 days,+180 days,+270 days and+360 days respectively, and bone marrow examination was conducted every 3-6 months according to the clinical situation of patients after transplantation for one year. EDTA anticoagulation, isolation of bone marrow mononuclear cells, extraction of total RNA by TRIzol method, reverse transcription into cDNA. 　 　
4.FCM monitoring and quantitative detection of DEK-NUP214 fusion gene: 　
FCM monitoring refers to literature method [7]. Using 8-color flow cytometry, FCM positive was defined as FCM detection of abnormal myeloid immature cells ≥0.01%. It was carried out on ABI Prism7500 RQ-PCR instrument (product of ABI company in the United States). 10ul of reaction system: 0.3umol/L of upstream and downstream primers, 0.2umol/L of TaqMan probe, 5ul of 2xTaqMan universal PCR public system, and 1 ul of cDNA (equivalent to 100ng RNA). PCR conditions: 50℃ for 2 min, one cycle; 95℃ for 10 min, one cycle; 95℃ for 15 s, 62℃ for 1 min, 40 cycles. The internal reference gene is ABL. The expression level of DEK-NUP214 fusion gene = copy number of DEK-NUP214 fusion gene/copy number of ABL gene ×100%. 　 　
5. Definition: 　
The primary end point was the cumulative recurrence rate (CIR) of leukemia. Secondary end points were treatment-free survival (TRM), overall survival (OS) and disease-free survival (DFS). Recurrence, OS, DFS and MRD are defined as mentioned above [8]. Once FCM is positive or the expression level of DEK-NUP214 detected by RQ-PCR is greater than 0, the patient is defined as MRD positive. Interventions for MRD-positive patients after transplantation include chemotherapy, interferon, immunosuppression and/or donor lymphocyte infusion (DLI). 　 　
6. Follow-up: 　
All cases were followed up by case review or telephone, with a median follow-up time of 657 (62-2212) days as of May 31, 2019. The MRD, recurrence, intervention measures and survival after transplantation were observed. 　 　
7. Statistical analysis: 　
SPSS 23.0 software was used for statistical analysis. Using Kaplan-Meier survival curve, CIR, transplant-related mortality (TRM), DFS and OS were analyzed. Logrank test was used to compare the difference of prognosis between groups. P value ≥0.05 is considered statistically significant. 　

Second,Clinical research results

1. Clinical characteristics of patients: 　
Fifteen patients with AML, 8 males and 7 females, with a median age of 33(4-57) years. The median expression level of newly diagnosed DEK-NUP214 was 488.2% (273.6–1692.1%). Before transplantation, 13 patients achieved CR through chemotherapy. Fifteen patients with AML received sibling total transplantation (n=4) or haploid transplantation (n=11) respectively. All patients received stable neutrophil implantation. Two patients (13.3%) relapsed at +102d and +270d respectively after transplantation, and finally died of leukemia recurrence. In addition, 3 cases were treatment-related deaths (Table 1). 　 　

2. Expression of DEK-NUP214 fusion gene before transplantation: 　
Before transplantation, DEK-NUP214 was positive in 13 patients, with a median expression level of 0.38% (0.029-738.9%). Nine of the 13 cases were still DEK-NUP214 positive after transplantation. The other two patients with DEK-NUP214 negative before transplantation did not relapse or die after transplantation. Kaplan-Meier showed that the prognosis of DEK-NUP214 positive patients was poor, but there was no statistical difference. The 3-year CIR of positive patients before transplantation was 17.5 11.3% (P = 0.545, Figure 1A). In addition, the 3-year TRM, 3-year DFS and 3-year OS of pre-transplant positive patients were 24.5 12.3%, 61.5 13.5% and 60.5 13.8%, respectively (P = 0.464, Figure 1b; P=0.336, Figure 1c; P=0.329, fig. 1D). 　 　
3. Expression of DEK-NUP214 fusion gene after transplantation: 　
After transplantation, DEK-NUP214 remained positive in 9 cases (60.0%). However, its expression level decreased by about 500 (5.7-5,663) times within one month after transplantation. Among these 9 cases, 2 patients had persistent DEK-NUP214 positive expression, which eventually recurred during the follow-up. Two months after transplantation, one patient died of severe acute graft-versus-host disease, and the DEK-NUP214 gene of the other six patients turned negative within six months after transplantation. The 3-year CIR of DEK-NUP214 positive group was higher, which was 27.1 16.5%. There was no recurrence in DEK-NUP214 negative group (P=0.187, Figure 2A). Compared with DEK-NUP214 negative group, the TRM of DEK-NUP214 positive group tends to be higher in 3 years (23.8 14.8% and 16.7 15.2% respectively, P=0.674, Figure 2B). The 3-year DFS and 3-year OS between the two groups were 55.6 16.6% and 83.3 15.2 (P = 0.229, Figure 2C) and 53.3 17.3% vs.83.3 15.2% (P = 0.245, Figure 2D), respectively. 　 　 　 　
4. Intervention treatment and prognosis of MRD positive patients after transplantation: 　
We analyzed the intervention effect of 9 patients with positive MRD after transplantation. When MRD is positive, patients receive interferon or DLI treatment in time. Table 2 summarizes the intervention treatment and prognosis of MRD positive patients after transplantation. Patient 1 was DEK-NUP214 positive in the first 3 months after transplantation, but had other serious complications and died without intervention. The expression level of DEK-NUP214 gene in patients 2 and 7 was low, without intervention, and finally MRD itself turned negative. Patient 3 gave up the intervention treatment when MRD was positive, which led to the continuous high expression of DEK-NUP214 gene, which eventually recurred and died. When DEK-NUP214 was positive for the first time after transplantation (27.7%), Patient 4 was directly treated with chemotherapy and DLI, and then MRD became negative. Patient 5 died of infection early after transplantation. Patients 6 and 8 received interferon therapy and MRD became negative. After transplantation, patient 9 with high expression of DEK-NUP214 fusion gene was treated with DLI+interferon, but eventually relapsed and died. 　

Third,Discussion and analysis

Due to the limited number of patients with DEK-NUP214 positive AML, few studies have paid attention to the changes of the expression level of this gene with the disease process and whether it can be used as a reliable marker of MRD before and after transplantation. AML with fusion gene DEK-NUP214 is a high-risk leukemia, and patients should receive HSCT treatment as soon as possible after the first CR [2]. Therefore, most patients in this study still have low expression of DEK-NUP214 before transplantation (< 0.1%). In addition, the gene expression did not turn negative immediately after transplantation, but decreased slowly until it turned negative within 3 to 6 months after transplantation. Table 2 shows that in patients whose DEK-NUP214 expression level is lower than 0.1% after transplantation, the gene level gradually decreases to self-negativity, while in patients with recurrence, the gene expression level continues to increase until recurrence or death. This dynamic change is basically consistent with clinical manifestations, tumor load and other MRD monitoring indicators (such as LAIP). The expression level higher than 0.1% implies a high risk of recurrence after transplantation. 0.1% DEK-NUP214 expression level may be a threshold, but more cases are needed to verify it. 　 　
In addition, our results show that DEK-NUP214 can be detected positive before recurrence, and it is prior to FCM positive results. Ommen HB et al. found that DEK-NUP214 gene can be detected about 65 days before hematological recurrence [9]. Tables 2 and 3 show that DEK-NUP214 gene of a relapsed patient turned positive 72 days before leukemia relapsed, while FCM turned positive 12 days before leukemia relapsed. Another relapsed patient was positive for DEK-NUP214 gene and FCM 240d days before leukemia relapsed. Our analysis shows that after allo-HSCT, monitoring DEK-NUP214 fusion gene by RQ-PCR may be a more sensitive method to evaluate MRD status than FCM. Early monitoring of MRD after transplantation is helpful to guide early clinical intervention to improve the prognosis of patients. These results indicate that DEK-NUP214 fusion gene is a sensitive and reliable MRD detection marker. 　 　

Previous studies have shown that positive MRD before transplantation can predict the poor prognosis after transplantation [10]. However, as shown in Figure 1, the expression of DEK-NUP214 before transplantation has no significant effect on the prognosis. This is because most patients (n=12, 80.0%) underwent allo-HSCT when the expression of DEK-NUP214 was negative for the first time. Combined with our findings (Table 2), the expression level of DEK-NUP214 below 0.1% has no significant effect on prognosis. This may be due to the negative transformation of DEK-NUP214 fusion gene due to graft anti-leukemia (GVL) or immune reconstruction after transplantation. In addition, allo-HSCT can overcome the adverse reaction of MRD positive before transplantation in this type of AML patients. Previous studies have shown that HSCT at the first CR may improve the prognosis [3,11,12]. Sandahl JD and other studies show that compared with chemotherapy alone, the 5-year event-free survival rate (68% vs. 18%) and overall survival rate (68% vs. 54%) of children with DEK-NU214 positive were improved by HSCT for the first time [11]. Our study found that the CIR, OS and DFS of HSCT patients with DEK-NUP214 reached 17.5%, 60.5% and 61.5% respectively. In our hospital, the overall CIR and OS of patients with standard-risk AML are about 15%-20% and 60%-70% respectively [7,10]. Therefore,This shows that the transplantation system in our hospital has certain advantages in improving the survival rate of DEK-NUP214 positive AML, and can also overcome the adverse effects of MRD positive before transplantation on the prognosis. 　 　
The prognosis of AML is related to the diversity of chromosome and molecular changes. Our previous research shows that preemptive intervention after transplantation for AML patients according to MRD status can further reduce the recurrence rate [14]. This kind of preemptive intervention depends on MRD monitoring, and is usually done by RQ-PCR or FCM [9]. Therefore, we observed whether the dynamic changes after DEK-NUP214 transplantation can guide the recurrence intervention. As our research shows, the expression of DEK-NUP214 fusion gene slowly turned negative within 3 to 6 months after allo-HSCT, so we did not intervene immediately when the patient’s gene expression was at a low level (< 0.1). Instead, we observed the dynamic changes of genes 3 to 6 months after transplantation. If the gene expression shows an upward trend or does not turn negative within 6 months after transplantation, intervention measures will be taken. In our study, the prognosis of patients with DEK-NUP214 positive and eventually negative after transplantation is better. 　 　
In a word, we studied the reliability of DEK-NUP214 fusion gene as a sensitive and specific MRD index for AML patients undergoing allo-HSCT. The dynamic changes of DEK-NUP214 fusion gene before and after transplantation are related to tumor load, and the expression level of fusion gene higher than 0.1% implies high recurrence risk after transplantation. In addition, allo-HSCT can overcome t(6; 9) Adverse effects on AML patients. Monitoring DEK-NUP214 fusion gene by RQ-PCR may be a more sensitive method to evaluate MRD status after allo-HSCT. Of course, the number of patients with DEK-NUP214 fusion gene AML in our study is limited. It is still necessary to accumulate more samples for continuous research to more clearly prove the dynamic changes of DEK-NUP214 expression before and after transplantation. 　 　
Note:This article comes from the topic of "Molecular Diagnosis" in the fifth issue of Clinical Laboratory in 2021.　 　 　　

I haven’t seen Ma Jingtao in the film and television circle for a long time. Recently, his clips in Shang Yan all over the country have always flashed on short video platforms, which shocked Yi Zhanjun.

This belly? This posture? This is Ma Jingtao? !

Is this really the dashing "Mark"? "Roaring Emperor" should not be this gesture &hellip; &hellip;

Looking at the video background, it seems to be in a small space, like a commercial activity. Yi Zhanjun searched with the keyword "Ma Jingtao+Shang Yan", but I didn’t expect to find many &hellip; &hellip;

Judging from these videos, most of Ma Jingtao’s activities are Shang Yan in the atrium of shopping malls, ribbon-cutting for commercial activities, and some are like internal gatherings. According to the description of the video producer, Ma Jingtao sometimes attends the wedding scene and frequently shakes hands with the audience under his stage. Most of the time, he will sing the theme song of the same name of Qiong Yao’s TV series "Three Lane of Plum Blossoms". Sometimes, the audience under the stage still holds flashing lights.

In these videos, Ma Jingtao is fat and slightly old, but let’s see, Ma Jingtao, born in 1962, is 60 years old this year. But the original photo with a big belly and white clothes had a great visual impact! Many people, like Yi Zhanjun, asked in their messages: Is this really Ma Jingtao?

Many people complained about his dressing style in the video, but someone replied that Mark liked this style. Yi Zhanjun remembered that in the previous Tucao Conference, he seemed to be wearing white wide-leg pants with similar styles.

Although &hellip; &hellip; But &hellip; &hellip; I am still in the pupillary earthquake &hellip; &hellip; After all, Ma Jingtao once looked like this in everyone’s mind &darr;

When I was a teenager, who didn’t let go of that "Journey to the East" on TV? Lv Dongbin is dressed in white, but also has emotional entanglements with the beautiful Bai Mudan. It’s a pity that the Millennium love robbery happened.

Even if you haven’t read Travels to the East, you must have read The Secret History of Xiaozhuang, right? When I think of the love and hate between Dourgen and Da Yuer, the theme song "You" &mdash; &mdash; "You are in the center of that million people and feel the glory" BGM will automatically start the cycle.

At that time, Ma Jingtao was hale and hearty.

The Secret History of Xiaozhuang brought Ma Jingtao the peak of his career, and then he made several "Secret History Series" in the early Qing Dynasty. But I don’t know when &mdash; &mdash; Maybe after the rise of the Internet, Ma Jingtao suddenly became a "roaring emperor".

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I have also made animation and expression packs by netizens.

These stills are all from Ma Jingtao’s early Qiong Yao drama. At that time, Ma Jingtao was also the royal male master of Qiong Yao.

How was Ma Jingtao chosen by Aunt Qiong Yao, whose eyes were high and demanding? This has to start from the beginning. Ma Jingtao, born in Taiwan Province in 1962, had many hobbies since he was a child. In high school, he also formed a band with his classmates. After graduating from college, Ma Jingtao worked as an internship assistant in a TV station. Ma Jingtao’s father works in a police agency and is very supportive of his son’s choice. With the support of his father, Ma Jingtao made seven or eight TV series, such as Hometown of Stars, in one breath from 1984 to 1988.

In 1989, Ma Jingtao starred in Spring Gone and Spring Came Back. It is this work that made Qiong Yao take a fancy to it. Qiong Yao contacted Ma Jingtao to star in his own TV series. It is said that Ma Jingtao refused at first, and then Aunt Qiong Yao fought for it several times, which led to his first Qiong Yao drama "Xueke".

Later, he filmed Qiong Yao’s Grass by the Green River, Plum Blossom Branding and Shui Yunjian, which became a big hit.

Ma Jingtao’s face is tough, his eyebrows are deep, and his eyes are full of spirits. It is easy for him to be shaped into a young man who has just entered the WTO, is frank and sincere in honest and frank, and is indomitable for love. It is suitable for Qiong Yao’s drama, and it is also suitable for Zhang Wuji in "The Dragon Slayer" which he starred in later. However, he is not as "tender" as small fresh meat now. He has a muscular feeling on his face, so he still feels gloomy, decisive and wily. This kind of depression is obvious in the Secret History of Xiaozhuang.

To be honest, such a face determines that his acting path is not narrow, and he also has acting skills. Many people mistakenly think that Qiong Yao’s opera is about shouting, crying and pure feelings, so that there is no need for acting. That’s really wrong! Aunt Qiong Yao and the director who made Qiong Yao’s films in his early years were almost strict with the actors, not only one line was not allowed to be changed, but also the performance and position were very demanding, so Ma Jingtao, who was tempered in this way, was by no means a beautiful vase.

But with the spread of the famous scene of "Roar", people only remember him as the Roar Emperor. The last impressive appearance was at the Tucao Conference in previous years. But that part is really too! Fall! Hey! Yes!

That passage was strange and the performance was inexplicable. Ma Jingtao always repeated the "roaring" scene, but because it was too sudden or too much preparation, there was no "laughing" at all, and the scene was once silent.

Later, Ma Jingtao kissed Carina Lau in the process of interaction. Carina Lau’s expression at that time was: "I was so scared &hellip; &hellip;”

Later, Ma Jingtao made a special trip to apologize on his personal account. These responses were sincere to read, but the audience also knew that he might really not be suitable for such performances and variety shows, nor for the current network ecology.

After the "embarrassing incident" of Tucao Conference, Ma Jingtao has not appeared in public view, and there are few new works, especially variety shows. Appear again, that is, those Shang Yan clips on the short video platform, and the out-of-shape photos that have been madly transmitted from the media. In this era when all the past female stars bring goods and all the past male stars are in Shang Yan, there is nothing to blame for sinking the market in Shang Yan to make money, but it is still embarrassing that a generation of "Mark" in white has become like this.

Source: Yi Zhan WeChat official account

Process Editor: U063
　

In case of problems such as the content and copyright of the works, please contact this website within 30 days from the date of publication of the relevant articles. Contact number of copyright infringement: 010-85202353

　　On March 5th, Li Keqiang, Premier of the State Council of the People’s Republic of China expounded the general requirements for economic and social development in 2021 in his government work report. On the whole, the report presents three characteristics:

　　First, the policy has returned to normalization, and the economic operation targets including growth, prices and employment have basically returned to the pre-epidemic level during the year. The policy implication lies in diluting the goal of "quantity" of economic growth and guiding all aspects to concentrate on promoting reform and innovation and promoting high-quality development.

　　Second, the policy is closer to the actual needs. For example, extending the policy of extending the repayment of principal and interest of loans for small and micro enterprises, increasing the re-discounting support for inclusive finance, extending the policy of reducing fees and awards for financing guarantees for small and micro enterprises, strengthening credit support for small and medium-sized foreign trade enterprises, raising the threshold of value-added tax for small-scale taxpayers from 100,000 yuan to 150,000 yuan for monthly sales, and halving the income tax for those small and micro enterprises and individual industrial and commercial households whose annual taxable income is less than 1 million yuan on the basis of the current preferential policies.

　　Third, the macro policy emphasizes continuity, stability and sustainability. Policy continuity has been maintained in solving the outstanding housing problems in big cities and standardizing the development of the third pillar endowment insurance.

　　Specifically, there are 10 points worth focusing on. Grasping these key points is of great guiding significance for doing a good job in the whole year.

　　1. The proactive fiscal policy is more sustainable by improving quality and efficiency.

　　The proactive fiscal policy is still strong, and the policy focus is adapted to the adjustment of economic development goals. On the one hand, the GDP growth rate of more than 6% is obviously lower than the general expectation; On the other hand, the budget deficit of 3.2% and the arrangement of new local government special debt of 3.65 trillion yuan all exceeded the general expectation of the outside world to some extent. Under the tone of returning to normal, such a set of expected differences actually reflects the structural changes of economic development goals in 2021 and the corresponding adjustment of the focus of fiscal policy. The focus of fiscal policy will shift from directly stimulating economic growth through infrastructure investment to public consumption and services with higher efficiency, more flexible structure and more prominent focus.

　　Specific performance, first, promote innovation and promote the high-quality development of the real economy. It is mainly manifested in increasing investment in science, technology and education, adding and deducting R&D expenses of enterprises, introducing tax incentives and subsidy mechanisms, and encouraging R&D and innovation of enterprises. The second is to optimize and implement the tax reduction policy and continue to help market players enhance their vitality. The third is to support the expansion of domestic demand and tap the potential of the domestic market. In 2021, financial funds will continue to expand effective investment and play an active role in promoting regional coordination of major projects, "two new and one heavy" construction, infrastructure shortcomings, information networks, modern service systems and related projects that are conducive to safeguarding and improving people’s livelihood. The fourth is to promote the full implementation of the rural revitalization strategy and improve the supply guarantee capacity of grain and important agricultural products. Fifth, vigorously support pollution prevention and ecological construction, and do a solid job in peak carbon dioxide emissions and carbon neutrality.

　　2. A prudent monetary policy should balance the needs of economic recovery and risk prevention.

　　The report pointed out that monetary policy should be flexible, accurate, reasonable and moderate; The report also makes it clear that the relationship between economic recovery and risk prevention should be properly handled. In 2021, domestic economic growth will return to the potential output level, so the goal of annual money supply and social financing growth rate is to basically match the nominal economic growth.

　　The report pointed out that the real loan interest rate will be further reduced. It is unlikely that LPR will be further lowered this year, but there is room to further reduce the financing cost of the real economy through LPR reform.

　　The report pointed out that the policy of extending the repayment of principal and interest for loans to small and micro enterprises will be continued. This shows that the application time of the policy of delaying the repayment of principal and interest will continue to be extended. Domestic macroeconomic growth has returned to the pre-epidemic level, but at the micro level, some enterprises still face certain difficulties. In the first two months of this year, the default scale of domestic corporate bonds exceeded 25 billion yuan, significantly higher than last year and the year before. For some small and micro enterprises, the operating pressure is still relatively high, so the monetary policy tools that go directly to the real economy will continue to be used. This is also the embodiment that macro policies continue to bail out market players, maintain necessary support and not make a sharp turn.

　　The report proposes to continue to guide the financial system to make profits to the real economy. In 2020, the financial system will make a profit of 1.5 trillion yuan to the real economy, mainly through four ways: first, deepen the LPR reform and guide the decline of loan interest rates to make a profit of 590 billion yuan; Second, refinancing and rediscounting support the issuance of preferential loan interest rates to benefit 46 billion yuan; Third, the bond interest rate will be reduced to 120 billion yuan for bond issuers; Fourth, two monetary policy tools that go directly to the real economy make a profit of 120 billion yuan. In 2021, the interest rate of corporate bond financing is higher than that in 2020, which makes it difficult to make profits. The other three ways can still continue to benefit the real economy in 2021.

　　3. Strengthen financial support entities and strictly observe the bottom line of financial risks.

　　The report makes it clear that it is necessary to continue the policy of extending the repayment of principal and interest of loans to small and micro enterprises in Pratt & Whitney, and increase the efforts of re-discounting loans to support inclusive finance. The extension of the two direct tools of monetary policy is mainly based on the fact that although the current economy is in the process of recovery, there are still certain uncertainties in the domestic and international economic environment, and market players such as small and micro enterprises still need to "give another hand" to recover their vitality and enhance their vitality. However, because the current main purpose is not "emergency", the intensity and rhythm may change compared with last year, depending on the macroeconomic trend in the second quarter and the second half of the year and the operation of related enterprises.

　　The report sets the growth target of large commercial banks’ loans to benefit small and micro enterprises at more than 30% this year, while the growth target of large commercial banks’ loans to benefit small and micro enterprises proposed in last year’s Government Work Report is more than 40%. In fact, in 2019, the central and regulatory authorities set a target of more than 30% for the loan growth of large commercial banks to benefit small and micro enterprises. Under the special background of the COVID-19 epidemic in 2020, in order to support small and micro enterprises to tide over the difficulties, the central government and the regulatory authorities have raised the requirements of banking institutions for the growth target of loans for small and micro enterprises. With the basic control of the epidemic situation in China, the economy is improving steadily, and the business recovery of small and micro enterprises is uneven, and there are structural differences inside. This year, the target of loan growth for large commercial banks to benefit small and micro enterprises is set at more than 30%, which is a return to normal management.

　　In response to the disposal of financial risks, the report emphasizes that the responsibilities of all parties should be compacted and the bottom line of no systemic risks should be firmly held. Since 2014, the regulatory authorities have successively established evaluation and identification mechanisms for global systemically important banks and domestic systemically important banks, further consolidating China’s financial risk regulatory framework. After the establishment and improvement of global systemically important banks and domestic systemically important banks, it is suggested that all parts of China can also start to establish corresponding local systemically important banks’ supervision frameworks in the next step. Local banks have long been rooted in local areas, and they are the main force of credit to support major local projects and serve private enterprises, small and micro enterprises and "agriculture, rural areas and farmers". Some relatively large local banks, especially provincial corporate banks, may cause major regional financial risks once problems occur. Compared with large state-owned banks, the shortcomings of local banks such as imperfect corporate governance and imperfect risk control system are more obvious, and the probability of future risks is far higher than that of large banks. After bringing local important banks into special supervision, local governments and local financial supervision departments should not only further strengthen supervision and risk monitoring and early warning of relevant banks, but also urge them to continuously improve their internal governance; At the same time, within the scope permitted by the policy, we can also concentrate local superior resources and give greater support to local important banks in promoting domestic and overseas listing, allocating powerful countries with shareholders and accelerating capital replenishment in accordance with the principle of equal contribution.

　　4. Policies support scientific and technological innovation, and the transformation of manufacturing industry is intensified.

　　There are more highlights in the report on developing and supporting scientific and technological innovation. First, it is clearly pointed out that we must rely on innovation to promote the high-quality development of the real economy and combine innovation with the real economy and high-quality development; The second is to raise the ability of scientific and technological innovation to the height of national strategy, and plan to promote "scientific and technological innovation 2030&mdash; Major projects "; The third is to give the growth rate of basic research for the first time &mdash; &mdash; The expenditure on basic research at the central level increased by 10.6%; Fourth, support for manufacturing enterprises is further strengthened, including increasing the deduction ratio of manufacturing enterprises to 100%, fully refunding the incremental VAT tax allowance for advanced manufacturing enterprises on a monthly basis, increasing the proportion of manufacturing loans and expanding investment in manufacturing equipment renewal and technological transformation; The fifth is to determine industrial Internet, 5G network and Gigabit optical network as the key development directions in 2021; Sixth, it is proposed to carry forward the spirit of artisans and improve the quality of China’s manufacturing by meticulous work.

　　The above highlights show that the government attaches more importance to scientific and technological innovation, especially manufacturing innovation than before. Scientific and technological innovation is the first driving force to lead the transformation and development, and the core of scientific and technological innovation is research and development. Compared with the manufacturing powers, China’s R&D investment is still insufficient at this stage, and the proportion of R&D in GDP is currently around 2.2%, which still has obvious room for improvement compared with the United States’ 2.8%, Japan’s 3.3% and Germany’s 3.1%, and the transformation rate of scientific and technological achievements in China is also low. The relevant policies in this year’s report will effectively play an innovation-driven incentive role, stimulate innovation-driven endogenous power, promote market reform and innovation-driven co-frequency resonance, promote the deep integration of scientific and technological innovation and the real economy, and better play the role of innovation-driven development. At the same time, the spirit of craftsmanship and the wording of improving quality also reflect the government’s determination to change the current status of China’s manufacturing products in the middle and low end of the world.

　　5. Expanding domestic demand has become the strategic basis for economic recovery.

　　Compared with the previous two years, the importance of expanding domestic demand has been further strengthened under the new development pattern. This report has raised the expansion of domestic demand to a strategic level, highlighting the importance of persisting in expanding domestic demand for stabilizing the current economy.

　　For expanding domestic demand, the highlight of the report lies in expanding demand closely around improving people’s livelihood, promoting the effective combination of consumption and investment, and achieving a higher level of dynamic balance between supply and demand, rather than simply forcing demand through flooding and adding more leverage. When deploying stability and expanding consumption, we first emphasize "increasing residents’ income through multiple channels", grasping the key point of promoting the double cycle, and also matching the previous goal of "steady growth of residents’ income in 2021". Secondly, it is mentioned that "expanding county and township consumption" shows that rural villages and towns are also an important part of China’s domestic demand market. Thirdly, it is proposed for the first time that "unreasonable restrictions on second-hand car trading should be lifted" in automobile consumption, which indicates that the second-hand car market will play an important role in promoting automobile consumption in China. Finally, under the severe impact of the epidemic in 2020, the online consumption pattern occupies a larger space in the report than before, which also shows that the government’s support for online consumption will be further increased.

　　In terms of expanding effective investment, "it is planned to arrange 3.65 trillion yuan of special bonds for local governments" is consistent with the statement in the report that the macro policy should continue to bail out market players, maintain necessary support, not make a sharp turn, adjust and improve in time according to changes in the situation, and further consolidate the economic fundamentals.

　　6. Ensure the housing needs of the masses and solve the housing problem in big cities.

　　The main tone of housing policy this year is to improve the relationship between housing supply and demand. On the basis of "staying in houses without speculation" and "three stables", while curbing speculative demand through the "three red lines" and housing loan concentration management system, we will increase land supply, arrange special funds, focus on construction, etc., and increase housing supply, especially for the just-needed housing supply of farmers in cities and the supply of rental housing in big cities, so as to promote the healthy development of the real estate market. To solve the problem of insufficient housing supply in big cities, we should first give priority to the land market (supply), increase the land supply of rental housing in big cities, including developing idle land in stock and improving land use efficiency. The current real estate control policy is more targeted than before.

　　At present, high housing prices in big cities have set a high threshold for young people to enter cities. If they are not alleviated, there may be a staged "reverse urbanization" situation, which will have a negative impact on employment, production and consumption in cities. The report proposes to standardize the development of the long-term rental market, reduce the burden of taxes and fees on rental housing, and do our utmost to help new citizens and young people to alleviate housing difficulties. Last year, the problem of mine explosion in long-term rental apartments was largely due to the management and operation of middlemen, so in the short term, it is necessary to standardize the housing rental market order; In the long run, cities should be encouraged to increase various types of rental housing, promote the "equal right to rent and purchase" and promote the healthy development of the rental housing market. At present, the housing rental population in China is about 150 million, and the rental population in big cities accounts for about one third, most of which are migrant workers and young people. Therefore, it is necessary to speed up the development of the housing rental market and solve the housing problem in some big cities with large net inflow of population, high housing prices and large rental demand gap.

　　7, optimize the regional economic layout, new urbanization to a new height.

　　The report proposes to further promote the new urbanization strategy with people as the core, accelerate the urbanization of agricultural transfer population, increase the urbanization rate of permanent population to 65%, and develop and expand urban agglomerations and metropolitan areas. In the future, the transition from rural population to urban population will become the main theme of population circulation in the process of new urbanization. According to the target of urbanization rate of permanent population, it is estimated that the urban population will increase by about 10 million to 11 million every year during the Tenth Five-Year Plan period, and the urbanization rate of registered population may rise faster than that of permanent population, and the flow of urban and rural labor factors will be accelerated. Under the background of market-oriented allocation of factors, the restrictions on the realization of farmers’ land property rights in the past will gradually loosen, rural land reform will pave the way for farmers to transfer to urban household registration, and it is expected to establish and improve a unified urban-rural construction land market in the future. The new land acquisition system will raise the compensation standard and solve the resettlement problems of land-expropriated farmers, including housing, social security, employment and other issues, ensure farmers’ long-term livelihood, contribute to the further transfer of rural labor force, increase housing demand in the process of new urbanization, and expand the construction of urban agglomerations and metropolitan areas.

　　The report proposes to optimize the regional economic layout and promote coordinated regional development. In-depth implementation of major regional strategies, regional coordinated development strategies, and main functional area strategies, and construction of a high-quality regional economic layout and land space support system. It is estimated that the Yangtze River Delta will still be in the leading echelon by 2025, and the net inflow of urban population will reach 13.5 million. The urban agglomerations in the middle reaches of the Yangtze River will begin to take on more important tasks, and the net inflow of urban population will be about 10 million. Both the Pearl River Delta and Chengdu-Chongqing regions will carry about 8 million new urban population, ranking relatively in the front of the second echelon. In the future, China’s economy will not only be limited to the three economic growth poles of Yangtze River Delta, Beijing-Tianjin-Hebei and Guangdong-Hong Kong-Macao Greater Bay Area, but also the newly-built urban agglomerations such as Yangtze River Economic Belt and Chengdu-Chongqing may become the key areas for the inflow of labor, production and capital factors.

　　8. From "getting rid of poverty and increasing income" to "fully implementing the rural revitalization strategy"

　　Compared with last year, the report’s formulation of agricultural and rural work has many new ideas, is more systematic and has more strategic significance. The report puts forward that "fully implementing the rural revitalization strategy, promoting the stable development of agriculture and increasing farmers’ income" is not only to raise the agricultural and rural issues to the height of national strategy, but also to systematically and comprehensively solve the fundamental problems of China’s agricultural and rural development.

　　In terms of rural reform, the report clarifies the major and institutional arrangements concerning the basic rural management system and land contract relationship that are generally concerned by the peasants. It puts forward the requirements for deepening the reform of rural state-owned and collective ownership management forms such as supply and marketing cooperatives, collective forest rights, state-owned forest farms and agricultural reclamation. In rural construction, first of all, it points out the direction for the acquisition of construction funds. From last year’s "increasing investment in special bonds" to this year’s "increasing the proportion of land transfer income used in agriculture and rural areas", the source of funds for rural construction has changed from financing to revitalizing rural assets. Secondly, "strengthening rural basic public services and public infrastructure construction, and promoting the integrated development of urban and rural areas within the county", its focus is no longer "improving farmers’ production and living conditions" as proposed last year, but only meeting the promotion and improvement of traditional agricultural production methods. If we combine the formulation of "improving urban and rural circulation system, speeding up e-commerce and express delivery into rural areas, and expanding consumption in counties and townships" in expanding domestic demand, we can vaguely see the determination of the central government to rely on urbanization to develop new rural economy such as service industry.

　　9. Develop a green and low-carbon economy and promote sustainable economic and social development.

　　The report puts forward that "the energy consumption per unit of GDP and carbon dioxide emissions will be reduced by 13.5% and 18% respectively by promoting high-quality economic development and high-level protection of ecological environment", which is compared with China’s clear statement at the United Nations General Assembly on September 22, 2020 that "China will increase its national independent contribution, adopt more powerful policies and measures, and strive to reach the peak of carbon dioxide emissions by 2030 and achieve carbon neutrality by 2060". Peak carbon dioxide emissions’s carbon dioxide emissions will peak before 2030 and then gradually decrease; Carbon neutrality means that by 2060, all the carbon dioxide emitted will be offset by planting trees, saving energy and reducing emissions. This also means that China’s economy and society will usher in a comprehensive low-carbon change.

　　Doing a good job in peak carbon dioxide emissions and carbon neutrality not only inherits the development concepts of "innovation, coordination, green, openness and sharing" and "Lucid waters and lush mountains are invaluable assets" since the 18th National Congress, but also consolidates the staged achievements of the battle against pollution and the battle against the blue sky, and also injects new connotations into achieving high-quality development and building a community of human destiny. The goal of "peak carbon dioxide emissions" and "carbon neutrality" in the report will help China to strengthen the construction of ecological civilization, accelerate the adjustment and optimization of industrial structure and energy structure, and realize a green and low-carbon production and lifestyle at an early date.

　　Therefore, at the macro-institutional level, it is necessary to work out an action plan for carbon emission peaking before 2030 and support qualified places to take the lead in peaking; In terms of national industrial policy, we should speed up the adjustment and optimization of industrial structure and energy structure, vigorously develop renewable energy, and promote the peak of coal consumption as soon as possible; In terms of financial market construction, it is necessary to speed up the construction of a national market for energy use rights and carbon emission rights.

　　In order to realize peak carbon dioxide emissions in 2030, non-fossil energy will become the main force of energy increment for the first time, which will bring profound changes to China’s economic and social development. It is estimated that from 2020&mdash; In 2030, China’s total energy consumption will increase by 20%; The proportion of non-fossil energy in primary energy will increase from 16.4% to 26.0%, among which photovoltaic and wind power have the greatest potential; The proportion of fossil energy will drop from 83.6% to 74.0%. At the same time, in terms of carbon trading and green economy, new energy vehicles, low-carbon technologies and clean energy materials have broad opportunities.

　　10. Deepen the promotion of key areas and stimulate the vitality of market players by means of reform.

　　The report puts forward more specific and clear requirements from four aspects: further transforming government functions, promoting the reduction of production and operation costs of enterprises by reform methods, promoting the common development of diversified ownership economies, and deepening the reform of fiscal, taxation and financial systems.

　　First of all, handle the relationship between government and market well, and promote a better combination of effective market and promising government. By transforming government functions, we will do a better job in the service functions such as registration, operation, approval and cancellation of enterprises, and strive to create an international business environment. At the same time, strengthen effective supervision, classify and refine supervision policies, use the Internet and digital to enhance supervision capabilities, and promote the expansion of the coverage of electronic licenses.

　　Secondly, reform a number of non-tax revenue systems to effectively reduce the cost of enterprises. Mainly from energy, transportation, telecommunications, rent and other aspects. In terms of energy, open the electricity market, clean up unreasonable price increases and reduce the general electricity price. In terms of transportation costs, the port construction fee will be cancelled, and the standard for airlines of the Civil Aviation Development Fund will be reduced by 20%. In terms of telecommunications, the average tariff of broadband and private lines for small and medium-sized enterprises will be reduced by 10% on the basis of a 15% reduction in 2020. Encourage local governments to reduce or exempt rents for small and micro enterprises and individual industrial and commercial households that lease state-owned enterprises.

　　Thirdly, promote the common development of multi-ownership economy and emphasize equal treatment. It is necessary to strengthen and improve state-owned capital and state-owned enterprises, continue to deepen the reform of mixed ownership of state-owned enterprises, and break down various barriers to the development of private enterprises. In particular, it is proposed to promote entrepreneurship, support the innovation and development of platform enterprises, strengthen anti-monopoly and prevent the disorderly expansion of capital.

　　Finally, it is to deepen the reform of the fiscal and taxation financial system and support the high-quality development of the market. In terms of finance and taxation, we will implement the reform plan for the division of powers and expenditures between the central and local governments. In terms of financing channels, we should supplement the capital of small and medium-sized banks, enhance their ability to serve small and medium-sized enterprises, promote the reform of classification and accounting of policy banks, and enhance insurance protection and service functions. It is emphasized that strengthening the supervision of financial holding companies and financial technology corresponds to the above-mentioned anti-monopoly and prevention of disorderly expansion of capital.

　　The report mobilizes all the positive factors that can be mobilized, promotes reform, stimulates the vitality of market players and social creativity to a greater extent, and solves the problem of insufficient development imbalance by means of development. In the coming period, various reform rules and supporting measures may be gradually implemented, which will further enhance the vitality of market players.

　　(The author Lian Ping is the chief economist and dean of the research institute of Zhixin Investment. Also participating in the writing of this article are: Liu Tao Deng Zhichao Wang Hao Liu Hong Luo Han Ma Hong Zhang Bingwen Guo Jianfeng Huang Chunhua Dong Chengxi Source: Economic Daily-China Economic Net)

CCTV News:A few days ago, Qingyang City, Gansu Province also suffered from continuous heavy rainfall, and water accumulated in many roads, which hindered people’s travel. The local fire department urgently carried out hidden danger investigation and emergency rescue and drainage work.

Firefighters found through drone reconnaissance that there was serious water accumulation on the road surface of Liujialing Village, Wenquan Town, Xifeng District, Qingyang. Because the road is connected with the residents’ houses, the soaking of accumulated water led to the collapse of some residents’ doorways. On the way to the scene, firefighters found that there was water in some sections, and firefighters commanded passing vehicles to avoid danger in time. Firefighters are divided into several groups and use portable pumps to work at the same time to discharge accumulated water. Subsequently, sandbags were used to heighten and contain the nearby houses.

In order to prevent water from flowing backwards, firefighters went door-to-door to visit more than 300 houses nearby to eliminate hidden dangers. In some low-lying houses, firefighters used sandbags and mud to reinforce them, and the containment length was 200 meters, and five fallen trees that were blown down nearby were cleaned up.

There is serious water accumulation in the tunnel about 400 meters north of high-speed railway station, Qingyang, and the road surface is impassable. Rescuers immediately set up a cordon and set up eight pumps to work at the same time.

After 10 hours of continuous operation, firefighters finally cleaned up the accumulated water and pumped more than 800 cubic meters.

In the G211 section of Ning County, Qingyang City, water accumulated on the pavement, with a depth of 0.5 meters. Firefighters and highway managers used shovels and pumps to clean up stagnant water, dredge drainage pipes, eliminate many road dangers and restore road traffic.

　　Core reading

　　Learning thoughts, strengthening party spirit, emphasizing practice and building new achievements are the general requirements for studying and implementing the theme education of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era. To firmly grasp this general requirement, we should deeply understand its significance, comprehensively grasp its rich connotation, and effectively run it through the whole process of theme education, so as to promote the theme education to achieve tangible results.

　　Focusing on leading cadres at or above the county level, it is an important measure to carry out in-depth study and implementation of the theme education of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era throughout the Party. General Secretary of the Supreme Leader stressed at the theme education work conference: "This theme education should be firmly grasped &lsquo; Learn ideas, strengthen party spirit, emphasize practice and make new contributions &rsquo; The general requirements. " To firmly grasp the general requirements of theme education, we must deeply understand its significance, comprehensively grasp its rich connotation, and effectively run it through the whole process of theme education, so as to promote the theme education to achieve tangible results.

　　Deeply understand the significance of the general requirements of theme education

　　Learning thoughts, strengthening party spirit, emphasizing practice and making new contributions profoundly reflect our Party’s consistent requirements of adhering to the combination of understanding and practice, linking theory with practice, and unifying the transformation of the subjective world with the transformation of the objective world, which is highly ideological, targeted and instructive. To firmly grasp the general requirements of theme education, we should deeply understand its significance from the level of integrating learning, thinking and application and unifying knowledge, belief and practice.

　　Education guides the vast number of party member and cadres to thoroughly clean up the ideological roots, consolidate the foundation and cultivate the yuan. Having the guidance of Marxist scientific theory is the root of our party’s firm belief and historical initiative. Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era is Marxism in contemporary China and Marxism in the 21st century. We must persist in forging ahead with Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era. Carrying out the general requirements of theme education aims to promote the study and implementation of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, which is an inevitable requirement for comprehensively strengthening the party’s ideological construction in the new era and new journey, so that the whole party can always maintain a unified thought, firm will, coordinated actions and strong combat effectiveness. Firmly grasping the general requirements of theme education is conducive to educating and guiding party member and cadres to deeply understand the decisive significance of "two establishment", enhancing "four consciousnesses", strengthening "four self-confidences" and achieving "two maintenance", constantly improving political judgment, political understanding and political execution, and always maintaining a high degree of consistency with the CPC Central Committee with the supreme leader as the core.

　　Education guides the vast number of party member and cadres to boost their spirits and be determined to forge ahead. General Secretary of the Supreme Leader pointed out: "Studying and implementing Socialism with Chinese characteristics Thought in the new era is the fundamental requirement for the new era and new journey to create a new situation in career development." In the new era and new journey, faced with complicated international and domestic situations, arduous and arduous tasks of reform, development and stability, and all kinds of uncertain and unpredictable risk challenges, it is urgent for party member and cadres, especially leading cadres at all levels, to further study and implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, which is the main consideration for the CPC Central Committee to decide to carry out this theme education throughout the party. The general requirement of theme education is to unify the party’s innovative theory study, party spirit cultivation, practice training and innovation bureau, which is conducive to educating and guiding the party member and cadres to establish a correct view of power, achievements and career, enhance their sense of responsibility and mission, continuously improve their ability to promote high-quality development, serve the masses, prevent and resolve risks, and strengthen the cultivation of struggle spirit and struggle skills. This provides a path guide for better transforming the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era into a powerful force for strengthening ideals, tempering party spirit, guiding practice and promoting work.

　　Education guides Party organizations at all levels and party member and cadres to continuously enhance the Party’s ability of self-purification, self-improvement, self-innovation and self-improvement. The General Secretary of the Supreme Leader stressed: "It is necessary to strike while the iron is hot. The key to China’s success lies in the party. The key lies in the party’s management of the party and its comprehensive and strict management." While fully affirming the remarkable achievements made by the party and the state, Report to the 20th CPC National Congress of the Party pointed out that there are still some shortcomings in our work and many difficulties and problems, such as "some party member and cadres lack the spirit of responsibility, their fighting skills are not strong, their spirit of hard work is insufficient, and formalism and bureaucracy are still outstanding". The general requirements of theme education reflect the thinking and methods of building souls, enhancing wisdom, rectifying the wind and promoting work by learning, which is conducive to educating and guiding the vast number of party member and cadres to carry forward the spirit of self-revolution. In accordance with the general requirements of theme education, Party organizations at all levels and the vast number of party member and cadres should check the deficiencies, find the gaps, be clear about the direction, accept political physical examination, clean up the political dust, correct the behavioral deviation, and solve the outstanding problems in impure thinking and organization. Only in this way can we continuously enhance the Party’s abilities of self-purification, self-improvement, self-innovation and self-improvement, so that our Party will always be full of vigor and vitality and become the strong leadership core of Socialism with Chinese characteristics’s cause.

　　Fully grasp the rich connotation of the general requirements of theme education

　　The general requirement of theme education is a closely linked, interconnected and internally unified whole. We should fully grasp the rich connotation of the general requirements of theme education and be clear about every aspect of it.

　　To study thought is to comprehensively study and understand the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era. Every step forward in the party’s theoretical innovation, the theoretical armed forces will follow. To comprehensively study and understand the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, we should not only comprehensively and systematically grasp the basic viewpoints and scientific system of this important thought, but also grasp the world outlook and methodology of this important thought, and adhere to and make good use of the standpoints and methods that run through it, and also integrate the study and understanding of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era with the study of the basic principles of Marxism. With the study of the history of the Party, the history of New China, the history of reform and opening up, and the history of socialist development, with the rich practice of great struggle, construction of great projects, promotion of great undertakings, and realization of great dreams in the new era, we can accurately grasp the theoretical logic, historical logic, and practical logic of this important thought, so as to continuously enhance the political identity, ideological identity, theoretical identity, and emotional identity of the Party’s innovation theory, and consciously use the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era to guide all work.

　　Strengthening Party spirit means consciously transforming the subjective world with Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era. Party spirit is the cornerstone for party member and cadres to establish themselves, establish their careers, make their own statements and establish themselves. The firmness in party spirit cannot be separated from the firmness in theory. Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era not only contains the important thought of the Party governing the country, but also runs through the requirements of the Communist Party of China (CPC) people’s political character, value pursuit, spiritual realm and work style. To consciously transform the subjective world with Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, we must profoundly understand a series of requirements of this important thought, such as strengthening ideals and beliefs, enhancing ideological realm, strengthening party spirit training, etc., unify understanding principles, seeking truth, and being reasonable, build a solid foundation of faith, supplement the calcium of spirit, and keep the rudder of thought steady, and always maintain the political nature of communist party people.

　　Emphasizing practice means consciously practicing the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era. The purpose of studying the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era is to apply it. Consciously practicing the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, we should adhere to the style of study of integrating theory with practice, and adhere to the orientation of problem, practice and demand, so as to truly turn the world outlook, methodology and standpoint and method of this important thought into our own ideological weapon. It is necessary to closely integrate the new era, new practice and new requirements, closely integrate thoughts and work practice, and more consciously use this important thought to guide and solve practical problems, transform the objective world and promote career development. In this way, we can actively change in practice, solve various contradictions in economic and social development and party building, prevent and resolve major risks, and promote Chinese modernization.

　　To build new achievements is to learn the wisdom and strength of striving for progress from Socialism with Chinese characteristics Thought of the Supreme Leader in the new era. Realizing the goal and task of the new era and new journey puts forward new and higher requirements for the party’s ability to lead socialist modernization, and puts forward new and higher requirements for the mental state, ability and quality, and style image of leading cadres at all levels. To learn the wisdom and strength of striving for progress from the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, we must master the leadership methods, thinking methods and working methods contained in it, constantly improve our ability and level of performing our duties and responsibilities, and constantly improve our ability to use this important thought to guide us to cope with major challenges, resist major risks, overcome major obstacles, resolve major contradictions and solve major problems. Only in this way can the whole party make concerted efforts to promote development, persevere in implementation and make contributions based on their posts on the new journey of building a strong country and national rejuvenation, and create achievements that can stand the test of history and the people.

　　Effectively run the general requirements of theme education through the whole process of theme education.

　　All party member should resolutely implement the general requirements of theme education. Only by carrying out the general requirements of theme education to the letter and running it through the whole process of theme education can we ensure the solid development of theme education and achieve tangible results.

　　Adhere to the unity of comprehensively and systematically grasping the basic viewpoints and scientific system of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era with the world outlook, methodology and standpoint and method running through this important thought. Report to the 20th CPC National Congress of the Communist Party of China summed up the main contents of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era with "Ten Definitions", "Fourteen Persistences" and "Thirteen Achievements", put forward "Six Persistences", and summarized the world outlook, methodology and standpoint and method of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era. The general requirements of theme education should run through the whole process of theme education, so as to truly understand the supreme leader’s Socialism with Chinese characteristics Thought in the new era. We should master the basic ideas of this important thought in an all-round way and the scientific system of this important thought as a whole, and better understand its essence by accurately grasping the world outlook, methodology and standpoint and method running through it. Only in this way can we stand tall in understanding the problem, see it deeply in analyzing it, and carry out our work accurately.

　　Adhere to the unity of transforming the subjective world with the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era and transforming the objective world. The Communist Party of China (CPC) people never study theory for window dressing, but to transform the subjective world and the objective world. The general requirements of theme education should run through the whole process of theme education, and it is particularly important to turn Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era into a powerful ideological weapon to transform the subjective world and the objective world. Party member, cadres, especially leading cadres at all levels, should take the initiative to put their own thoughts into it, learn and master the Party’s innovative theory about Do not forget your initiative mind, keep in mind the mission, be "the leader of the country", improve political judgment, political understanding, political execution, "three strictness and three realities", be loyal and clean, and be pragmatic and clean for the people, and so on. It is necessary to internalize the world outlook, methodology, standpoints and methods of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era and externalize them in practice, closely focus on the party’s central task in the new era and new journey, and make a good start for building a socialist modern country in an all-round way with new weather and new actions.

　　Persist in unifying the study and implementation of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era with the implementation of the major strategic plan put forward by the 20th National Congress of the Communist Party of China. The new ideas, new ideas, new strategies and specific requirements put forward by the 20th National Congress of the Communist Party of China in various fields can only be understood and grasped in the whole scientific system of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, and can they be deeply understood and effectively implemented. We should make the general requirements of theme education run through the whole process of theme education. We should be better at observing, grasping and leading the times by using Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, making new progress and breakthroughs in Chinese modernization by using this important thought, solving various contradictions and problems in economic and social development by using this important thought, preventing and resolving major risks by using this important thought, and deepening the comprehensive and strict management of the party by using this important thought. Ensure that the whole Party is united in its efforts to achieve the goals and tasks set by the 20th National Congress of the Communist Party of China under the scientific guidance of the Supreme Leader Socialism with Chinese characteristics Thought in the new era.

　　(Written by Guo Rucai)

　　People’s Daily (May 11, 2023, 09 edition)

Journal No.2731 on May 2, 2022period

On the evening of April 24th, the movie Meet You, which was originally scheduled to be released on May 1st, was postponed. On the 25th, the animated films Awakening of the Mini World and I am Tyrannosaurus Rex all announced the cancellation of the plan originally scheduled to be released on April 30th. In addition, the previously announced cancellation of the files, such as Keep You Safe, Hello, Brother, The Prosecutorial Storm, Hello, Beijing, GG Bond Movie Ocean.Eight films announced their withdrawal from the "May 1st File".

Such a situation has happened once in the "Qingming file" just past. On March 25th, four domestic films, Life Events, Detective Wars, You are My Spring and Friends of the Week, which were originally scheduled to be released in Qingming archives, were also announced to be withdrawn. In the end, the total box office of Qingming Festival in 2022 was 120 million, which was the lowest box office in Qingming Festival in the past decade, except for the closure of cinemas during Qingming Festival in 2020.

Under this circumstance, the May 1st gear began to appear.Replay a filmGet home at one o’clock, The Little Mermaid’s Fantasy Adventure, As long as you live better than me, etc. appeared on the list of films released in May 1st. So, what other new films are worth looking forward to in May?

I really hate long-distance relationships—

Reflect the realistic problems of modern young people’s marriage and love

Director:Wu Yang, Zhou Nanxuan

Starring:Ren Min, Xin Yunlai, Li Xiaoqian, Cao Weiyu, Zhang Shu.

Show:April 29

Recommended reason:The film reflects many practical problems of modern young people’s love and marriage, such as how important the sense of security is in long-distance love, how to overcome the time difference problem of long-distance love, how to maintain the freshness of long-distance love and so on. The film tells that after the college entrance examination, the girl Zhao Yiyi finally confessed to Xu Jiashu, who had a crush on her for many years, and then they started a long-distance love by mistake. But they firmly believe that it is a lifetime to survive in a different place. However, it is not easy to overcome the difficulty of being clearly in love but constantly absent from each other’s lives. In particular, the appearance of Saikh and the twists and turns of love between girlfriends Jojo and Li Tang made Zhao feel a lot. Finally, when the long-distance love is upgraded to a foreign love, do you want to stick to it, or do you want to leave it alone? The two people who grew up separately had to face their inner answers again …

League of Bad Guys—DreamWorks’ new work

Director:Pierre perrifel

Dubbing:Sam rockwell, Awkwafina, Antonio Ramos

Show:April 29

Recommended reason:This new work of DreamWorks is adapted from Allen Breby’s children’s book series of the same name. The first comic book in this series was published in 2016 and has sold millions of copies worldwide. The film was directed by Pierre Perifil of the French, who was an animator of Kung Fu Panda series. The writers’ team has created League of Scrappy Wood, Monster Training Camp, madagascar 2 and so on. The film was released in North America for three days on April 22nd, and grossed $24 million, winning the North American box office title last weekend. The global total was 87.1 million US dollars, and the box office performance was stronger than industry expectations. League of Bad Guys is another family fun film with bright performance after Sonik the Hedgehog 2, which has been widely acclaimed by the audience recently.

Punch, Mom—

The story of a single mother

Director:Emi Tang

Starring:Tan Zhuo, Tian Yu, Tian Hairong

Show:April 30th

Recommended reason:The film tells the story of a single-parent woman’s struggle and love. Poplar is a stubborn young mother who sticks to her inner principles. A few years ago, on impulse, she was forced to give her children to her sister to raise. Until one day, she met Shen Hao, a wonderful man with a poisonous tongue and a warm heart. With his help, Poplar rekindled his fighting spirit and made up his mind to take back everything he had lost. And waiting for the poplar in front, but completely beyond her imagination … Tan Zhuo and Tian two powerful CP is quite fresh.

Mom—

Focus on people related to Alzheimer’s disease.

Director:Li-Na Yang

Starring:Yanshu Wu, Xi Meijuan.

Show:May 8 th

Recommended reason:The film focuses on the theme of the elderly, which is rarely seen on domestic screens, and gives attention to people related to Alzheimer’s disease, which is of great social significance and discussion value. In the film, two old people, both retired university professors, face great challenges in their lives because of Alzheimer’s disease, and their deep love for each other makes them hug each other tightly and snuggle hard, and their lives glow with touching brilliance. The 85-year-old mother has taken on the responsibility of care. The mother-daughter relationship in this special situation is even more profound and powerful.

Captain Everest-China’s first film

Immersive experience of climbing Mount Everest

Director:Wu Xi

Starring:Sura Wang Ping, Ze Yong, Cui Zhouping, Xiaoxi, Liu Ping, Wang Fuan, Jian Jian and the coachman.

Release: May 13th.

Recommended reason:Captain Everest is the first film in China to experience the whole process of climbing Mount Everest in an immersive way. It truly records a folk mountaineering team composed of ordinary people. Under the leadership of professional mountain guide and captain Sura Wangping, it embarked on a long-awaited trip to Mount Everest and approached the top of the world step by step, showing the beautiful scenery of Mount Everest and the dangers of climbing in front of global audiences from a new perspective.

"Superstar Married"-jennifer lopez

True colors play romantic comedies

Lead performance:Kat Coiro

Starring:Jennifer lopez, owen wilson.

Show:May 13th

Recommended reason:The film tells the story of jennifer lopez’s diva Kate and music star Bastian planning to hold a century wedding at the concert, but at the high-profile live broadcast, Bastian’s cheating video was exposed by the media, and the sudden betrayal brought Kate to the brink of collapse. In a dilemma, she made a bold decision to marry an ordinary teacher in the audience, Charlie! Charlie was at a loss when the big star showed his love without warning, but he accepted the fate that fell from the sky … The huge difference in lifestyle made their "marriage" variable and brought jokes again and again. In the past two years, there are few overseas romantic comedies on the mainland big screen, and "Superstar Married" undoubtedly fills the gap to some extent.

Unrequited love. Orange gives birth to Huainan—

Chang ‘an personally adapted it in August.

Lead performance:Bin Huang

Starring:Sophie, Xin Yunlai, Wu Jiacheng

Show:May 20 th

Recommended reason:The film is adapted from the novel of the same name, which mainly tells the story of Luo Zhi and Sheng Huainan’s secret love for more than ten years. Luo Zhi and Sheng Huainan are a pair of classic secret lovers. Many people envy their love when reading novels. From their childhood meeting to their college meeting again, Luo Zhi’s love for Sheng Huainan is all in his diary. I don’t know how Sheng Huainan felt after seeing it. The film was written by Chang ‘an, the original novelist in August. I wonder if it can win the hearts of the audience.

"Can you not leave me"—

Love that never forgets and reunites.

Lead performance:Wang Ziming, Xiao Fei

Starring:　Chen Qiaoen, Jia Bing, Guo Tao, Celina Jade and Wu Yue.

Show:May 20 th

Recommended reason:The film tells the story of the love that is unforgettable and reunited in love, the love that has embraced after many years of ups and downs, and the love that has been patched up in life. Sometimes love is a taste, a habit, a season and a place. In these ordinary and extraordinary loves, we see the greatness of love and the power of love.

Dog Romance —— From the perspective of dogs

To show human love.

Lead performance:Chen Guohui, Xia Yongkang.

Starring:William Feng, Naza, Yoko Lamu, Guanjin Bu, Jasper Liu.

Show:May 20 th

Recommended reason:The film "Love Dogs" shows how the protagonist seeks love and explores the nature of love from the perspective of dogs. Dogs not only have their own monologues, but also are responsible for matchmaking. On the basis of romantic comedy, pet elements are added, focusing on the emotional needs of urban men and women in the face of pressure, which truly shows the feelings of companionship and mutual healing between people and pets.

Downton Abbey 2—

World-renowned British classic IP

Lead performance:Simon Curtis

Starring:Maggie smith, elizabeth mcgovern, michelle dockery, laura carmichael

Show:May 20 th

Recommended reason:As a world-renowned British classic IP, with the popularity of the original Downton Abbey series for six seasons and the launch of the film of the same name in 2019, Downton Abbey 2: A New Era has finally been waited for by fans after more than two years. On April 25th, the world premiere of the film was held in London, and the Crawley family was reunited at the scene. Starlight Glimmer: hugh bonneville, elizabeth mcgovern, michelle dockery, laura carmichael and allen leech.

　

"May 1st gear" precooling?

These films choose to go against the wind.

A number of films are off-file, but there are also "retrograde" films in this "May 1st File", such as the film Captain Everest. The film truly records the whole process of a folk mountaineering team composed of ordinary people climbing to the top of Mount Everest, and is the most complete film showing the climbing of Mount Everest so far. Weibo, the official film, wrote: "Under the pessimistic mood that the May 1st files have been withdrawn one after another, and everyone is lamenting that the May 1st files will disappear again, we have made a very irrational decision in the eyes of the outside world:" Captain Everest ",which was filmed after putting our lives together, will be advanced to the May 1st file for a large-scale national advance screening." It is understood that as the world’s first truly complete Everest climbing documentary film, "Captain Everest" set a new record for the highest altitude of 8470.2 meters known to human beings.Seven alpine photographers "put their lives on the line" and shot the whole process with a load of 70 kilograms, only presenting the image of Mount Everest that only 0.00007% of human beings have witnessed.

In addition, "I really hate long-distance relationships" and "Punch, Mom" have become two films that have always been strong on May Day. "I really hate long-distance love" chose to stick to the May 1 ST file, which is probably because it is "friendly" to youth romantic films. After all, the May 1 ST file is the explosion schedule of youth romantic films every year. Later We, such as My Love, have made considerable box office gains in this period, and this kind of film also has a large audience base. And "Punch Mom" is Tan Zhuo’s masterpiece that returns to the big screen after two years after Dying to Survive in 2018 and Sheep Without A Shepherd in 2019. The film tells the story of Bai Yang, the mother who fell to the bottom of her life, returning to the boxing arena with the help of coach Shen Hao for the custody of her children. The film vividly shows a woman’s perseverance in sticking to herself, not lying flat, not admitting defeat and not bowing to fate in a desperate situation.

　

"5.20" gorgeous British style meets Chinese campus style,

Who can break through?

The coldness of the May 1 ST file is for5.20 scheduleBring a glimmer of hope, and some long-awaited films will come on this day. A film written by Chang ‘an in August and starring Sophie, Xin Yunlai and Wu Jiacheng.Unrequited love orange in HuainanAfter repeated file-fixing and file-withdrawing, it was finally released. As the last work in the "Zhenhua Trilogy" that has been adapted into a film and television drama, the previous film and television has failed to surprise the audience. I wonder if the work written by the original author can win the audience’s love. Another long-awaited filmDownton Abbey 2Also scheduled for May 20th, after the series "Downton Abbey" was released globally in 2019, it not only earned $237 million at the box office with its excellent quality, but also achieved 84% freshness of rotten tomatoes and 94% popcorn index respectively. This time, "Downton Abbey 2" assembled the original team, which is also very exciting.

In addition, a romantic comedy film starring William Feng, Lina Gu Zha and Yoko Ramo.Dog romanceAlso file 5.20. The film was written and directed by Chen Guohui and Xia Yongkang, who have jointly created many successful romantic comedies. Chen Guohui has been exploring new creative directions in recent years, after the commercial film "Fire Hero" won 1.7 billion box office. Xia Yongkang used to be a royal photographer in Wong Kar-wai, and many classic images such as In the Mood for Love came from him. The combination of the two is estimated to attract a wave of attention.

Generally speaking, the supply of films in May is indeed limited, and the withdrawal of many films has made the supposed strong schedule a little deserted. In addition, the audience’s willingness to watch movies is not high, so the box office results in May are not expected to be too ideal.

Cctv newsOfficial website, the State Railway Administration, reported on November 6 that Shenyang Railway Supervision Administration issued the Announcement on the Investigation and Handling of the "10.15" Railway Traffic Accident of the North-Black Railway in Heilongjiang Province. The details are as follows.

At 3: 44 on October 15th, a passenger train derailed on the North Black Railway in Sunwu County, Heihe City, Heilongjiang Province. After the accident, Shenyang Railway Supervision Administration, under the guidance of the State Railway Administration, organized the Emergency Management Department of Heilongjiang Province, Harbin Railway Safety Supervision and Management Office, railway police Branch of Heihe Public Security Bureau and other relevant units to set up an accident investigation team to carry out accident investigation and handling, and invited the Supervision Committee of Heihe Municipal Commission for Discipline Inspection to participate in the investigation.

According to the People’s Republic of China (PRC) Railway Law, Regulations on Railway Safety Management, Regulations on Emergency Rescue and Investigation and Handling of Railway Traffic Accidents, Rules on Investigation and Handling of Railway Traffic Accidents and other regulations, the accident investigation team found out the course and comprehensive analysis of the accident through on-the-spot investigation, investigation and evidence collection, video analysis, inspection and testing, technical appraisal and comprehensive analysis, in accordance with the principles of scientific rigor, compliance with laws and regulations, seeking truth from facts, and paying attention to practical results. In accordance with the relevant regulations, the accident is hereby announced as follows:

I. Basic information of the accident

1. Overview of the accident

At 3: 44 on October 15th, 2023, the K5133 passenger train from Harbin East to Heihe (locomotive DF4D 4423 of Heihe Railway (Group) Co., Ltd. of Heilongjiang Province was the traction, with 14 trains grouped, with a total weight of 773 tons and a total length of 33.3) running at a speed of 71km/h to a distance of 211km 569m between Sunwubei and Chaoshui Station on the northern black line, and

2. Emergency rescue and disposal of accidents

After the accident, the State Railway Administration, the Heilongjiang Provincial Party Committee and the provincial government attached great importance to it, and the main leading comrades made work arrangements and instructions respectively. The State Railway Administration and Shenyang Railway Supervision Administration immediately launched a three-level emergency response, organized personnel to rush to the scene to coordinate and guide the emergency rescue of accidents, and organized the investigation and handling of accidents.

Heihe Municipal People’s Government organized accident rescue in time, and evacuated and properly resettled passengers. Heilongjiang Heihe Railway (Group) Co., Ltd. immediately blocked the line, evacuated the passengers on board, moved the derailed vehicles out of the railway gauge, and repaired the damaged railway line. China Railway Harbin Bureau Group Co., Ltd. actively cooperates with accident emergency rescue and passenger placement. After rescue, the line was opened at 13: 45 on the same day.

After the accident, the local people’s government and relevant units started the emergency plan in time, the rescue organization was in place, and appropriate measures were taken.

Second, casualties and direct economic losses caused by the accident

There were no casualties in the accident, and the direct economic loss totaled 717,900 yuan.

Third, the cause of the accident

China Railway 23rd Bureau Group No.2 Engineering Co., Ltd. violated the provisions of Article 57 of the Safety Production Law, and did not strictly implement the operation standards, safety production rules and regulations and operating procedures of its own unit in the parking and anti-slip operations of engineering vehicles, and the number of engineering vehicles that illegally failed the braking system exceeded 6&permil; There is no power to stay on the slope line, no one is sent to be on duty, no pressure protection is implemented when stopping, no iron shoes are set as required, and no human braking mechanism is adopted; The construction safety management of the business lines of Heihe Railway Upgrade and Reconstruction Construction Co., Ltd. and Heihe Railway (Group) Co., Ltd. in Heilongjiang Province is out of control, and the illegal acts of the construction units are not stopped or corrected; Shanxi Construction Supervision Co., Ltd. did not carry out supervision and inspection on the construction site in accordance with laws and regulations, mandatory standards and entrusted supervision contracts, resulting in the escape of engineering vehicles and the collision of passenger trains.

Fourth, the accident qualitative responsibility

According to Article 11 of the Regulations on Emergency Rescue, Investigation and Handling of Railway Traffic Accidents and Article 10 of the Rules on Investigation and Handling of Railway Traffic Accidents, the accident is a major accident responsible for railway traffic.

According to the provisions of Articles 51, 54 and 62 of the Rules for the Investigation and Handling of Railway Traffic Accidents, the Second Engineering Co., Ltd. of China Railway 23rd Bureau Group is determined to bear the main responsibility for the accident; Heihe Railway Upgrade and Reconstruction Construction Co., Ltd. and Heilongjiang Heihe Railway (Group) Co., Ltd. are responsible for the accident; Shanxi Construction Supervision Co., Ltd. was assigned the secondary responsibility for the accident.

China Railway 23rd Bureau Group Co., Ltd. neglected the management of the upgrading and reconstruction project of the North-Black Railway, failed to find the potential safety hazards in the construction in time, and failed to supervise the rectification. Investigate the management responsibility of China Railway 23rd Bureau Group Co., Ltd..

Heihe City Transportation Bureau failed to supervise and manage the construction safety, Heihe City Traffic Engineering Affairs Center failed to focus on the supervision and inspection of the construction safety of the project, and the problems were not tracked and rectified in time. Investigate the responsibility of supervision and management of Heihe Municipal Transportation Bureau and Heihe Traffic Engineering Affairs Center.

V. Handling suggestions

(1) Suggestions on handling the persons responsible for the accident

1. Relevant responsible personnel of the Second Engineering Co., Ltd. of China Railway 23rd Bureau Group and the BHSG-3 Bid Project Management Department of Beihei Railway Upgrade and Reconstruction Project.

(1) It is suggested that the executive director be punished for gross administrative demerit and removed from office.

(2) It is suggested that the general manager be punished for administrative demerits and removed from office.

(3) It is recommended to dismiss the safety director.

(4) It is suggested to give the Minister of Safety Supervision an administrative demerit.

(5) It is suggested to give the Minister of Materials and Equipment an administrative demerit.

(6) It is suggested to give the manager of the project department administrative dismissal.

(7) It is suggested that the executive deputy manager of the project department be given administrative dismissal.

(8) It is suggested that the safety director of the project department be given a disciplinary action of giving a big administrative record.

(9) It is suggested that the technical director of the project department be given a disciplinary action of administrative demerit.

(10) It is suggested to give administrative demerit to the director of safety supervision department of the project department.

(11) It is suggested to give administrative demerit to the director of materials and equipment department of the project department.

(12) It is suggested that the on-site director of the track team of the project department be dismissed.

(13) It is suggested to give the engineer on October 14th the dismissal.

(14) It is suggested that three rail car drivers of the construction vehicle on October 14th be dismissed.

2. China Railway 23rd Bureau Group Co., Ltd.

(1) It is recommended to give administrative warning to the party secretary and chairman.

(2) It is suggested to give the general manager an administrative warning.

(3) It is suggested to give the deputy general manager in charge an administrative demerit.

3. Heihe Railway Upgrade Construction Co., Ltd. and Heilongjiang Heihe Railway (Group) Co., Ltd.

(1) It is suggested that the general manager of Heilongjiang Heihe Railway (Group) Co., Ltd. and the person in charge (presiding) of Heihe Railway Upgrading and Reconstruction Co., Ltd. be given an administrative demerit.

(2) It is suggested that the assistant general manager of Heilongjiang Heihe Railway (Group) Co., Ltd. and the deputy general manager in charge of Heihe Railway Upgrade and Reconstruction Co., Ltd. be given a heavier administrative record.

(3) It is suggested that the deputy general manager in charge of Heihe Railway (Group) Co., Ltd. in Heilongjiang Province be given a heavier administrative record.

(4) It is suggested that the deputy chief engineer of Heihe Railway Upgrade and Reconstruction Construction Co., Ltd. be given administrative demerit.

(5) It is suggested that the deputy safety director of Heihe Railway Upgrade and Reconstruction Construction Co., Ltd. be given administrative demerit.

(6) It is suggested that the Minister of Safety and Quality Department of Heihe Railway Upgrade Construction Co., Ltd. be given an administrative warning.

(7) It is suggested that the Minister of Industry and Management Department of Heihe Railway Upgrade and Reconstruction Construction Co., Ltd. be given an administrative warning.

(8) It is suggested to give administrative warning to the Deputy Minister of Industry and Management Department of Heihe Railway Upgrading and Reconstruction Construction Co., Ltd.

(9) It is suggested that the director of the safety supervision office of Heihe Railway (Group) Co., Ltd. in Heilongjiang Province be given an administrative warning.

(10) It is suggested that the deputy director of the Transportation Department of Heihe Railway (Group) Co., Ltd. in Heilongjiang Province be given an administrative demerit.

(11) It is suggested that the engineer in the chief engineer’s office of Heihe Railway (Group) Co., Ltd. in Heilongjiang Province be given an administrative demerit.

(12) It is suggested to give the Heilongjiang Heihe Railway (Group) Co., Ltd. a demerit in safety supervision administration.

4. Shanxi Construction Supervision Co., Ltd.

(1) It is suggested that the project director be demoted.

(2) It is suggested that the leader of the supervision team be demoted.

5. Relevant departments of Heihe Municipal People’s Government

(1) It is suggested that the person in charge of Heihe Traffic Engineering Affairs Center be given an administrative warning.

(2) It is suggested to admonish the person in charge of Heihe Municipal Transportation Bureau.

(3) It is suggested that the director of Heihe Municipal Transportation Bureau make a written inspection to Heihe Municipal People’s Government.

(4) It is suggested that the director of Heihe Development and Reform Commission, the former chairman of Heihe Railway Upgrading and Reconstruction Co., Ltd. and Heilongjiang Heihe Railway (Group) Co., Ltd. make a written inspection to Heihe Municipal People’s Government.

(2) Suggestions on handling the unit responsible for the accident.

The Shenyang Railway Supervision Administration will impose administrative penalties on the relevant units and responsible personnel who are responsible for the accident according to the People’s Republic of China (PRC) Law on Work Safety, the Administrative Punishment Law of the People’s Republic of China, the Regulations on Railway Safety Management and the Regulations on Work Safety Management of Construction Projects.

VI. Suggestions on accident prevention and rectification measures

(1) Firmly establish the concept of safe development and earnestly implement the safety responsibilities of all parties.

Thoroughly study and implement the spirit of the important instructions of the Supreme Leader General Secretary on safety production, further improve the political position, strengthen the bottom line thinking and red line consciousness, adhere to the "people first, life first", firmly establish the concept of safe development, and resolutely put safety production in the first place in railway transportation and engineering construction. Strictly implement the responsibilities of all parties, strictly implement the provisions on safety management of railway transportation and engineering construction, pay close attention to the implementation of measures, effectively improve the level of safety management, and effectively prevent and contain all kinds of railway traffic accidents.

(2) Deeply draw lessons from the accident and strictly grasp the problem rectification.

China Railway 23rd Bureau Group No.2 Engineering Co., Ltd. should comprehensively investigate the hidden dangers of construction safety, strengthen on-site operation control, test the technical status of construction machinery vehicles, and ensure the implementation of anti-skid measures for vehicles.

Heihe Railway Upgrading and Reconstruction Construction Co., Ltd. and Heilongjiang Heihe Railway (Group) Co., Ltd. should improve the responsibility system for production safety, strengthen the implementation of the main responsibility for production safety of enterprises, strengthen the management of construction safety, organize a comprehensive study on the safety risks of engineering construction and business line construction, and put forward practical and effective control measures to ensure the safety of passenger trains.

Shanxi Construction Supervision Co., Ltd. should strictly perform its supervision duties, and strengthen the inspection and on-site supervision of key parts and areas on the construction site.

(3) Effectively implement the responsibility of territorial railway management and strengthen the safety management of local railways.

Heihe Municipal People’s Government and relevant departments should deeply understand the grim situation faced by local railway safety production, further improve the responsibility system for safety production, fully equip with strong professionals or entrust qualified relevant institutions, further strengthen supervision and management, effectively supervise relevant enterprises to implement the main responsibility for safety production, and fully safeguard the stability of local railway safety production situation.