Special feature of 1905 film network The lively Spring Festival holiday has gradually gone away, and everyone has to go back to school and enter the new year’s work and study. Netizens are also full of flowers and activities in the face of the start of construction. The topic # I also quit the Spring Festival file # ranked first in Weibo hot search, and everyone expressed their feelings about the holiday on the Internet.

In fact, the source of the topic # I also quit the Spring Festival file # comes from a "spectacle" in the history of this year’s Spring Festival file. Originally, there were eight movies in the Spring Festival file, and at the end of the holiday, four movies quit the Spring Festival file one after another, namely "Huang Qi: God of Wealth".

No one expected that the Spring Festival in 2024 would end in such a dramatic way, but at the same time, the film industry also started a vigorous and comprehensive "resumption of work" after the Spring Festival, with the release, project establishment and shooting of new films … … A lively and extraordinary scene.

Take over the Spring Festival file, and many blockbusters are waiting to be shown.

After the end of the Spring Festival file, the newly recorded movie box office and the number of people watching movies have also made many films ready to show their talents in this "post-Spring Festival file".

The first film was released during the Lantern Festival this weekend. The former is the director’s film focusing on the spy story after the Kingsman series, and the latter is the box office champion of the Spring Festival in Hong Kong this year. The first film in this series also won over 100 million yuan in the mainland market.

In March, the movie market will begin with the re-screening and usher in the centralized release of Hollywood blockbusters, and the sci-fi blockbuster, classic IP Kung fu panda 4, monster blockbusters and Marvel Comics Chaoying’s "Lady Spider: Super Sensation" will be released in turn, bringing viewers a variety of viewing experiences.

In addition to these blockbusters, the winner of the Palme d ‘Or at the 76th Cannes Film Festival will also be released on March 29th. Will this more artistic and personal film be favored by domestic audiences again?

What is more noteworthy is that domestic films with diverse themes will also land on the big screen one after another in March: the starring film will be fixed on March 1, and the crime film with allusions will explode in word of mouth; On March 8 th, the romantic film starring in it was "lost" and "lost" in spring.

On March 15 th, the two generations, the grandparents and grandchildren, staged a warm and redeemed "two-way trip"; Viva La Vida, which was removed from the Spring Festival, is scheduled to be released again at the end of March.

On the whole, the content and theme of the films scheduled for March are diverse, and the excellent films at home and abroad compete on the same stage, which is a far cry from the situation in which the comedy of the Spring Festival is the mainstay, and it is expected to attract more differentiated audiences.

The news of new films keeps coming, and the film market is ready to go.

The films to be shown are all gearing up, and the news of the new film project and shooting is endless.

At the height of the road show’s popularity, the official announced the news of the new film "Turn to Flowers", which brought a great wave of attention to the new film with the help of YOLO’s popularity, and the film was still starring Jia Linghe and two "Ling Girls", so the film also filled the audience with expectations.

The manslaughter 3 has already been put on record and started. Last year, the producer Chen Sicheng and the screenwriter he participated in brought great surprises to the film market, so manslaughter 3 also hung the appetite of many viewers.

The director’s "The Runaway" has also been put on record. In the past, most of the works directed by Cao Baoping were "applauding and not selling", but last year’s performance exceeded expectations, so it is also curious about the possibility of the new film directed by Cao Baoping.

The director who hasn’t released his works for a long time also has the news of the new film "Heroes Out of Teenagers". The screenwriter of the film is good at telling stories from a female perspective, and the representative works are all films from a feminine perspective. This cooperation between You Xiaoying and director Jiang Wen will spark something different, which is expected.

The director’s assembled actors, such as,,,, and so on, whose strength and popularity coexist, are currently in hot shooting. Recently, Zhang Ziyi’s 15-second preview was released. Although it is only a short ten seconds, it has already brought people a full shock.

We expect more and more film creators to bring more good films to the audience, which will greatly enrich people’s cultural life, and at the same time promote the sustained and good development of China’s film market, from a big film country to a strong film country!

　　Should employees who have no room leave their collective accounts after leaving their jobs? How to solve the problem of buying a house but the original indoor staff refused to move their accounts? There is no room in Beijing, and parents are collective households. How should newborns settle in Beijing? These problems that have plagued Beijing residents will usher in solutions.

　　In order to promote the innovation of the concept and mechanism of household registration management, and effectively solve the problem of household registration personnel in this city who do not have the conditions to migrate in the city for the time being, according to the regulations on household registration in People’s Republic of China (PRC), the norms for the registration of permanent residence in police stations (Trial) and other laws and policies, the Beijing Municipal Public Security Bureau, after full investigation and extensive consultation, decided to set up a "public household" in the city’s household registration police stations, which will be implemented from June 1, 2021. The specific provisions are as follows:

　　I. Establishment of "public households"

　　In principle, only one non-agricultural "public household" is set up in each household registration police station in the city to receive non-agricultural registered permanent residence personnel in this area who do not have the conditions for urban migration for the time being.

　　Second, the "public households" settled conditions

　　Meet one of the following circumstances, the city’s household registration personnel (excluding student accounts, Beijing office accounts, postdoctoral accounts and other restrictions on the transfer of household registration in the city), you can apply for "public households" to settle in the local police station:

　　(1) I have to move out because of the house property transaction account, but I, my spouse or other immediate family members (other immediate family members include parents, children, (foreign) grandparents and (foreign) grandchildren. The same below) there is no legal property housing in this city, and the account cannot be moved out;

　　(two) because the account must be moved out after divorce, but I, my spouse or other immediate family members have no legal property housing in this city, and the account cannot be moved out;

　　(three) because the resignation account must be moved out of the original unit collective households, there is no collective households in the current unit, and I, my spouse or other immediate family members have no legal property housing in this city, and the account cannot be moved out;

　　(four) because of the change of the ownership of housing transactions or the change of the right to rent public housing, the right holder of the house now applies to move out the original indoor staff, and the original indoor staff refuses to move out without justifiable reasons;

　　(five) one of the biological parents of the newborn is registered in the "public household" of this Municipality, and the newborn can not declare birth registration at other addresses in this Municipality, but can declare birth registration in the "public household" where his biological parents are registered;

　　(six) other special reasons in this city can not be moved in registered permanent residence city.

　　Three, "public households" transfer procedures

　　(a) the required documents and materials

　　1. Application for entering the household. (A natural person under the age of 18 or other persons with limited capacity for civil conduct or persons without capacity for civil conduct shall be handled by his guardian on his behalf, and relevant materials on guardianship shall be provided. The same below)

　　2. The applicant’s Household Registration Book or Permanent Population Registration Card. If you do not move in yourself, you must also submit the power of attorney signed by the client, the resident’s household registration book or the resident’s identity card and other valid identity documents. (If the owner of the house or the lessee of the public housing applies for the relocation of the resident in the house, it is not necessary to provide the relevant identification materials of the resident.)

　　3. Housing property transactions must provide relevant documents such as the House Purchase and Sale Contract, the House Ownership Certificate or the Certificate of Immovable Property Rights; If the lessee of public housing changes, a new lease contract and a description of the public housing unit shall be provided; Divorce must provide a divorce certificate, a divorce agreement filed by the Civil Affairs Bureau or a court judgment or a court mediation; Those who leave the company must provide the resignation certificate, employee social security payment records and other relevant materials that can prove that they have left the company. If there is a new unit, it is also necessary to provide a description of the non-collective households with the administrative official seal of the new unit.

　　4 newborns in the "public households" to declare birth registration, according to the city’s newborn declaration of birth registration workflow.

　　5. Notice and Receipt of Notice (Annex 1), Commitment Letter for Moving into Public Households (Annex 2) or Commitment Letter for Housing Owners or Public Housing Tenants to Apply for Relocation of Stayed Accounts (Annex 3).

　　6. Other necessary materials.

　　(two) the process and time limit

　　1. The process and time limit for the applicant or guardian to apply for moving into a "public household"

　　(1) Persons who meet the requirements of "public households" should apply to the police station where their household registration is located by the applicant or guardian;

　　(2) The police station where the household registration is located shall review the materials submitted by the applicant or guardian, and if the materials are complete and accepted on the spot, the applicant or guardian shall be informed of the materials that need to be supplemented at one time;

　　(3) The public security organ shall complete the audit work within 35 working days from the date of accepting the materials. If it is necessary to consult the higher authorities, the period of asking for instructions shall not be included in the processing time limit;

　　(4) If the applicant meets the conditions for moving into a public household, the public security organ shall notify the applicant to go through the immigration formalities within 10 working days from the date of notification.

　　2. The process and time limit for the owner of the house or the lessee of the public housing to apply for moving the resident of the house into the "public household"

　　(1) the owner of the house, the lessee or guardian of the public housing shall apply to the police station where the house is located;

　　(2) The police station where the house is located shall review the materials submitted by the applicant or guardian, and if the materials are complete and accepted on the spot, and the materials are incomplete, the applicant or guardian shall be informed of the supplementary materials at one time;

　　(3) The public security organ shall complete the handling work within 35 working days from the date of acceptance. If it is necessary to consult the higher authorities, the period of asking for instructions shall not be included in the handling time limit;

　　(4) Before making a decision on account transfer, the public security organ shall inform the persons staying in the account or their guardians, and inform them that they have the right to state and defend themselves according to law. If it is impossible to inform, the public security organ will announce it for 30 days (the announcement period is not included in the processing time limit);

　　(5) If the person staying in the account or his guardian fails to make statements and arguments or move the account within 7 days after receiving the notice or after the expiration of the announcement, or if the reasons for statements and arguments are not adopted by the public security organ, the public security organ will move the account to a "public account" on its own.

　　3 "public households" indoor personnel to move out of "public households" for the process and time limit

　　(1) voluntarily move out of the "public household", the "public household" indoor personnel or guardians shall apply to the local police station;

　　(2) After examination and approval by the public security organ, if the indoor staff of the "public household" or their spouses or minor children have legally owned houses with the conditions to settle down, the indoor staff should move out of the "public household" after being informed by the public security organ. If it is impossible to inform, the public security organ will make an announcement for 30 days (the announcement period is not included in the processing time limit). "Public households" indoor staff after receiving the notice or within 30 days after the expiration of the announcement did not make statements and arguments or did not move the account, or the reasons for statements and arguments were not adopted by the public security organs, the public security organs themselves to move the account.

　　(3) The indoor staff of "public households" or their spouses and minor children have one or more sets of houses with legal property rights in our city, and all of them have the conditions to settle down. The settled people voluntarily choose the registered address of the house. If the settled people do not choose, according to the principle that the real estate address has no priority in household registration, the specific relocation settlement order is as follows: ① I am the sole right holder, and according to the date of property rights registration, choose the house registered account with the earliest registration date; 2 I share with others and choose a housing registration account with a large share; Share is consistent, according to the earliest registration date of property rights.

　　4. The public security organ shall deliver it to himself or his guardian within 7 days after making the decision to transfer the account by itself. If it cannot be delivered, it can be delivered by announcement. The scope and method of the announcement should be easy for the relocated person or his guardian to know, and the announcement period is 30 days (the announcement period is not included in the processing time limit).

　　5. If the relocated person or his guardian refuses to accept the decision of the public security organ to transfer the household registration, he may apply for administrative reconsideration or bring an administrative lawsuit according to law.

　　Fourth, the management of "public households"

　　(a) the public security organs for the "public households" indoor staff to print the "permanent population registration card", valid for 1 year. Indoor staff of "public households" should apply to the local police station for renewal of the permanent population registration card within 14 working days before the expiration of the permanent population registration card;

　　(two) "public households" indoor staff need to use the "public households" home page, should apply to the local police station, the police station issued a copy of the home page stamped with the "public households" special seal;

　　(three) the applicant shall ensure that the documents provided are true and accurate. If the application materials are fraudulent, the public security organ will cancel its application for relocation; If it constitutes an illegal crime, administrative criminal responsibility shall be investigated according to law. The applicant’s untrustworthy information is included in the city’s public credit information service platform.

　　Matters involving other accounts shall be handled in accordance with existing policies. (CCTV reporter Zhao Xuerong)

Fast technology news on December 30, this September, Huawei announced that the new HarmonyOS NEXT is ready to go, and Hongmeng native applications are fully launched.

A few days ago,"Hongmeng Pioneer Application Zone" is officially launched in the Huawei app store. These applications are placed in the Hongmeng Pioneer Application Zone to represent that Hongmeng native application development is under development or has been completed.

It is reported that there are currently around 150 applications that have launched or completed the development of Hongmeng native applications.

These include Autonavi Maps, QQ Music, iQIYI, Himalayas, QuickPass, Douyin, 360 Mobile Browser, Alipay, Meituan, Jinri Toutiao, Xiaohongshu, Weibo, Kugou Music, Bilibili, Dragonfly FM, China Construction Bank, Flush, Romance of the Three Kingdoms: Strategy Edition, and more.

It should be reminded that the current applications in the Hongmeng Pioneer Application Zone are all promoted in advance and play a showcase role. If you want to experience the native application of Hongmeng, you still have to wait until 2024.

It is understood that,The developer preview of HarmonyOS NEXT, known as "Pure Blood", will be available to developers in Quarter 1, 2024.

With the launch of HarmonyOS NEXT next year, users will also truly experience a smoother, smarter, and safer "Pure Blood Hongmeng" application, which is worth looking forward to.

(Report)

At the 2020 China Biotechnology Innovation Conference, experts pointed out that stem cells, as strategic resources, are strategic, public-spirited and supportive, in which the strategy is for national security and future competition, the public-spirited is for population health and social development, and the supportive is for scientific, technological, industrial and economic development. It is an important measure to ensure people’s health to collect, store, develop, utilize and share strategic stem cell resources and promote clinical transformation.

Stem cell resources are important strategic resources of the country. How to safely and effectively preserve China’s special, unique and rare human biological resources is of great significance for promoting China’s population health, maintaining the safety of life resources and treating major diseases.

One of the important values of stem cells is their application in disease treatment.

Professor Thomas C. Sudhof, winner of the Nobel Prize in Physiology or Medicine, once said, "We can control the disease and stem cells are a very good treatment. " Stem cell research will bring new hope to the problems that traditional medical treatment can’t solve.. "

Internationally, the United States, South Korea, Japan, the European Union and so on have approved stem cell therapy products listed, and stem cell therapy for diseases is becoming a more extensive reality.

By April, 2021, more than 1,200 clinical trials of mesenchymal stem cells were retrieved from ClinicalTrials.gov website.

In recent years, this number has continued to increase, indicating that the importance of mesenchymal stem cells is increasing.

At present, the research and development of stem cell drugs in China is becoming more and more standardized, attracting a lot of capital and talents. At the moment when the results are about to blow out, we look forward to this market by combing the foreign mesenchymal stem cell drugs.

According to incomplete statistics, there are 18 mesenchymal stem cell products that have been approved for marketing in the world, and 10 products meet the definition of drugs.

18 products related to mesenchymal stem cells (including orphan drugs, conditionally approved drugs, medical products, etc.); The date and country of approval are the first approval; Multistem is not counted, because its official website claims that the drug is not mesenchymal stem cells.

01

More flowers, Mesoblast

Prochymal: graft versus host disease

Country: USA, Canada, New Zealand

Date: May 2010

Cell type: bone marrow mesenchymal stem cells

Indications: graft versus host disease, Crohn’s disease

Price: $200,000/course of treatment

Initially, the FDA of the United States approved it as an orphan drug for the treatment of type I.

In 2012, Prochymal was sold to Mesoblast in Australia, and was approved for marketing in Canada and New Zealand to treat acute graft-versus-host disease.

In 2015, Mesoblast cooperated with JCR and renamed it Temcell to be listed in Japan.

Temcell: graft versus host disease

Country: Japan

Date: February 2016

Cell type: bone marrow mesenchymal stem cells

Indications: graft versus host disease

Price: about $120,000/course of treatment.

As mentioned above, Temcell was formerly Prochymal of Osiris Company and Ryoncil of Mesoblast Company.

In 2019, TEMCELL was approved to treat epidermolysis bullosa and neonatal hypoxic-ischemic encephalopathy.

In JCR’s financial report, Temcell’s sales revenue was about 18 million US dollars in 2018 and 28 million US dollars in 2019.

MPC: bone repair

Country: Australia

Date: July 2010

Cell type: autologous mesenchymal precursor cells

Indications: bone repair

Price: unknown

In 2010, the MPC(Mesenchymal Precursor Cell) independently developed by Mesoblast was approved for listing in Australia for the repair and regeneration of damaged tissues.

Mesoblast’s current market value is about $1 billion, and its business income of $6.6 million in fiscal year 2020 comes entirely from Temcell, mainly from milestone payments ($25 million) from China, Japanese and other partners.

02

Try first, Korea FDA

CellGram: acute myocardial infarction

Country: Korea

Date: July 2011

Cell type: autologous bone marrow mesenchymal stem cells

Indications: Acute myocardial infarction

Price: $15,000

CellGram was used by coronary angioplasty within 72 hours after chest colic to improve the left ventricular blood cell count in patients with myocardial infarction. After 6 months of treatment, the measurement showed that each treatment improved the left ventricular ejection fraction by 6%.

By 2017, this therapy has created sales of about $7.8 million. However, CellGram failed to meet the requirements of treating 600 patients within a six-year period, and Pharmicell applied to reduce the minimum number of patients to 60, which was rejected.

Some industry observers speculate that South Korea will cancel its approval, but this is the first stem cell drug in South Korea. "The cancellation of approval will have a harmful impact on the national reputation, and we must make a cautious decision."

Cartistem: degenerative arthritis

Country: Korea

Date: January 2012

Cell type: umbilical cord blood mesenchymal stem cells

Indications: Degenerative arthritis and knee cartilage injury.

Price: 19,000-21,000 USD

In the eight years since Cartistem was put on the market, the cumulative sales have exceeded 18,000 doses.

From 2017 to 2020, Cartistem has sold more than 10 billion won (about 9 million US dollars) for four consecutive years, which is obviously better than the other three stem cell drugs approved by South Korea (the annual sales are less than 5 billion won).

Medipost quarterly sales trend (millions of won, source: Medipost)

Researchers such as Kim SJ conducted a retrospective analysis of 128 product users, and found that after two years of follow-up, the pain and function of these patients were improved, which was statistically significant.

At present, the product has completed phase I and IIa clinical trials in the United States, and phase II clinical trials are being carried out in Japan.

Cupistem: Crohn’s disease

Country: Korea

Date: January 2012

Cell type: autologous adipose-derived mesenchymal stem cells

Indications: complex Crohn’s disease complicated with anal fistula

Price: 3000-5000 USD

Cupistem is used to reduce inflammation of Crohn’s fistula.

In a phase II clinical trial, 43 patients were evaluated for fistula healing after 12 months, and 80.8% of them showed complete fistula healing. After 24 months, 75% of these patients were completely closed, showing sustainable safety and therapeutic effect.

NeuroNATA-R: amyotrophic lateral sclerosis

Country: Korea

Date: July 2014

Cell type: autologous bone marrow mesenchymal stem cells

Indications: amyotrophic lateral sclerosis, motor neuron disease

Price: USD 18,000-72,000 (according to weight)

NeuroNATA-R is a stem cell therapy provided by Corestem Company of South Korea. Mesenchymal stem cells need to be collected from the patient’s own bone marrow four weeks before each injection of stem cells.

In the phase I clinical trial to evaluate the safety, 7 patients received intrathecal injection twice and were followed up for 12 months. The research shows that it has good security.

03

Not to be outdone, Japan and India

Stempeucel: Severe limb ischemia

Country: India, ratified by EU.

Date: June 2015

Cell type: bone marrow mesenchymal stem cells

Indications: thromboangiitis obliterans

Price: $2,200 (2017)

In 2015, Stempeucel was approved by the European Medicines Agency (EMA) as an orphan drug to treat thromboangiitis obliterans.

In 2017, the General Administration of Drug Administration of India (DCGI) granted Stempeucel a limited marketing license to treat patients with severe limb ischemia caused by Buerger’s disease. In 2020, DCGI completed the formal approval.

The research and development of Stempeucel lasted for 12 years and finally became the first allogeneic cell therapy product approved for commercial use in India.

Alofisel: Crohn’s disease

Country: Japan, EU ratification

Date: March 2018

Cell type: adipose-derived mesenchymal stem cells

Indications: complex perianal fistula in patients with Crohn’s disease

Price: about $70,000/course.

In 2018, Takeda, a Japanese pharmaceutical giant, and TiGenix, a Belgian stem cell company, jointly announced that EMA had approved Alofisel (CX 601) for the treatment of Crohn’s disease complicated perianal fistula whose fistula failed to respond to at least one traditional or biological therapy.

However, Alofisel encountered some difficulties in obtaining the so-called third-level approval, which is a term used to refer to national payer insurance. For example, NICE in the UK refused to recommend Alofisel on the grounds that it did not benefit much from clinical trials.

In 2019, Takeda decided to adopt value-based pricing in Europe. In other words, if patients do not improve, they will bear part or all of the expenses.

In the fiscal year ending March 31st, 2020, Takeda earned about $350,000 from Alofisel.

Stemirac: spinal cord injury

Country: Japan

Date: 2018-12

Cell type: autologous bone marrow mesenchymal stem cells

Indications: spinal cord injury

Price: $135,000

The listing of Stemirac is somewhat controversial. It only did phase II clinical trials, and it was conditionally approved and included in the national health insurance.

This move was criticized by Nature, who thought that there was no control group in its clinical trial, and there were only 13 subjects in the treatment group. The Japanese side responded that setting up a control group may cause moral problems.

According to an article in 2019, Stemirac will bring about $3.4 million in revenue to Nipro every year in the next nine years.

04

The pace of clinical treatment of stem cells in China is accelerating!

According to the data of National Medical Products Administration Drug Evaluation Center, up to now, eight new drugs of mesenchymal stem cells have been applied for clinical approval in China, and the indications are acute graft-versus-host disease, rheumatoid arthritis, ischemic stroke, knee osteoarthritis and diabetic foot.

Source: CDE

At present, the supervision of stem cell therapy in China adopts a "dual-track management model". National Health Commission mainly manages clinical research conducted by medical institutions, and the Food and Drug Administration is mainly responsible for stem cell therapy products that are applied for marketing after clinical trials are completed according to drugs.

In recent two years, the clinical application of stem cells in China has been standardized under the "dual-track management model".Up to now, 74 stem cell clinical research projects have passed the record of National Health Commission. Eight applications for new stem cell drugs have been approved by the Food and Drug Administration..

Compared with the past few years, the clinical transformation of stem cells in China is developing with a brand-new trend, and the blank of domestic stem cell listed drugs is expected to be filled faster.

At present, in the field of stem cell transformation, the research in China mainly focuses on stem cell bank, stem cell drug application, preclinical research and clinical trials. The gradual improvement of regulatory policies has pushed the clinical transformation of stem cells in China to a new development situation.

First, China has entered a new stage of development of new stem cell drugs.The promulgation of "Technical Guiding Principles for Research and Evaluation of Cell Therapy Products (Trial)" clarified the standard of stem cell therapy as a drug declaration, and at the same time, the new drug approval system of "60-day clinical trial implied permission" provided new development opportunities for the research and development and declaration of new stem cell drugs in China.

Second, the national "stem cell and transformation research" focuses on promoting the development of stem cell therapy drugs.For example, one of the assessment objectives pointed out in the key special declaration guidelines is to develop cell therapy drugs for a major or rare disease, apply for registration of new stem cell drugs and apply for clinical approval of stem cells.

Third, the policy encourages the strength of comprehensive enterprises to promote the clinical transformation of stem cells.In the past two years, some domestic policies explicitly support qualified 3A hospitals to cooperate with qualified social forces to declare and carry out stem cell clinical research, that is, to support and encourage qualified social forces or preparation institutions (enterprises) to join the stem cell industry and jointly promote the clinical application and development of stem cells. The promotion of enterprise innovation forces has accelerated the development and application of stem cells in China.

At present, there are still many diseases that need innovative therapies to solve the unmet clinical needs, and the expansion of indications for new stem cell drugs is precisely to meet these needs.

05

Perinatal tissue stem cells have gradually become mainstream.

Perinatal tissue is one of the largest sources of mesenchymal stem cells, and it has become a popular source of stem cells for new drug research and development. Mesenchymal stem cells derived from perinatal tissues have the advantages of multi-directional differentiation potential, immunological characteristics, convenient and harmless material collection, wide sources and easy industrial preparation, which has become a new trend of medical development. At present, more than 60% of the new stem cell drugs that have obtained clinical approval in China use mesenchymal stem cells derived from perinatal tissues.

In the treatment of severe patients in COVID-19, mesenchymal stem cells derived from perinatal tissues have also shown a good effect. Domestic research reports show that the critically ill patients in COVID-19 were transferred out of ICU after 9 days of reinfusion of mesenchymal stem cells from perinatal tissues, and most vital signs and clinical trial indicators returned to normal, and both throat swab tests were negative for Covid-19.

In recent years, immune cells derived from perinatal tissues have gradually become a research hotspot. Previously, the FDA approved the clinical trial of immune cells derived from human placental stem cells to treat COVID-19, which was developed by Celularity, a biotechnology company in New Jersey, USA.

In the early trial, as many as 86 patients with symptomatic COVID-19 will be treated to evaluate the safety of the treatment and the ability to prevent patients from getting worse.

Internationally, placental cell therapy products are also accelerating the pace of entering the market. For example, placenta-derived adherent cell PLX-PAD, which has attracted much attention in recent years, is being designed to treat patients who do not need tissue or genetic matching.

This therapy has passed the accelerated approval routes in the United States and the European Union, including the quick approval qualification of the US FDA and the Adaptive Pathways program of the EU EMA, for the treatment of limb ischemia. In addition, PLX-PAD has also been used in clinical research of other indications, including intermittent claudication, orthopedic indications, pulmonary hypertension and women’s health, and some of them have entered clinical phase III.

At present, China’s stem cell industry has formed a huge market scale. With the clinical transformation and market development, the era of stem cells benefiting patients in China will also come.

　　If you are annoyed that your expensive perfume doesn’t smell so good in a bottle after being sprayed on your body, or the fragrance disappears within an hour after you leave home, then there may be something wrong with the way you use perfume.

　　Francis Courgian, a famous French perfumer who has made popular perfumes of Dior, Burberry, Lancome and other famous brands, recently revealed five misunderstandings of women’s use of perfume in an interview with Vogue magazine.

　　Kurgian pointed out that to make perfume release the best taste, you must consider the environment in which you use perfume and the clothes attached to it. Not only that, if you are not used to wearing perfume every day, you’d better buy a small bottle, because the shelf life of perfume is usually only three months. As for how to use perfume correctly, let’s listen to what this perfumer has to say.

　　If you’re in the habit of spritzing your wrists and then rubbing them together, you’re actually ruining the scent.

　　If you are used to spraying perfume on your wrists and rubbing them against each other, you are actually destroying the fragrance.

　　That’s because the friction "heats up the skin, which produces natural enzymes that change the course of the scent", with the top and middle notes being worst affected as well as the dry-down – the long period during which the fragrance unfolds.

　　This is because friction "will make the skin warm, thus producing natural enzymes that will change the fragrance stage", and the former and middle tones are most affected, and the latter tone-the long process of fragrance release-will also be affected.

　　If you’re wearing a floral perfume, for instance, this heat makes it lose its crispness.

　　If you use floral perfume, the heat will make it lose its fresh taste.

　　To keep your fragrance smelling like it should, as well as making it last longer, spritz it once and then simply let it sink in.

　　In order to make your perfume give off its beautiful fragrance and make it last longer, you just need to spray it and let the perfume penetrate into your skin by itself.

　　Don’t DON’T KEEP IT IN THE BATHROOM.

　　Perfume is extremely sensitive to environmental changes and will be impacted by changes such as going from cold to hot.

　　Perfume is extremely sensitive to external changes and will be affected, such as the temperature changing from cold to hot.

　　This process sets off "unexpected chemical reactions within the natural ingredients" of the perfume such as patchouli, meaning your perfume will age faster and start to smell "off".

　　Temperature changes will trigger "unexpected chemical reactions between natural ingredients (such as patchouli)" of perfume, which means that your perfume will "age faster" and start to "taste bad".

　　The best way to store your fragrance is in its original box at room temperature.

　　The best way to store perfume is to put it in an original box and put it in a room temperature environment.

　　Dooopt for small sizes chooses perfume in small bottles.

　　If you are lucky enough to have lots of bottles or you don’t use your favourite perfume every day, oxygen will start to break down the molecules as it languishes on your dressing table.

　　If you are lucky enough to have many bottles of perfume, or if you don’t use your favorite perfume every day, then oxygen will start to break the molecular structure of perfume and make it gradually evaporate and deteriorate on your dressing table.

　　A typical bottle has a shelf life of three months so if you’re not using a perfume daily, you’re best off buying a smaller variety.

　　The shelf life of a typical perfume is three months, so if you don’t use perfume every day, you’d better buy a small bottle.

　　Or you could decant your bigger bottles into smaller containers and keep them in the fridge to maintain perfection.

　　Or you can pack your big bottle of perfume into several small bottles and put them in the refrigerator to keep the perfect fragrance.

　　DO EMBRACE SYNTHETICS chooses perfume with artificial ingredients.

　　The idea of a perfume that boasts of being all-natural might sound appealing, but the fragrance may well let you down.

　　Perfume under the banner of pure nature may sound attractive, but the fragrance of this perfume will disappoint you.

　　Musk, which was formerly derived from animals, is probably the most popular fragrance ingredient but must be created synthetically.

　　麝香很可能是最受欢迎的香水原料，过去取自于动物，现在只能人工合成。

　　Other popular smells, such as peony, freesia, and lily of the valley, can’t be extracted naturally as they don’t release enough aroma so they must be re-created.

　　其他受欢迎的香味，比如芍药、小苍兰、铃兰，不能通过自然手段提取，因为这些花释放的香味不足，所以必须人工再造。

　　According to Kurkdjian the ideal formula is a blend of essential oils, absolutes, and man-made ingredients.

　　Kurgian pointed out that the most ideal perfume formula is a mixture of essential oil, purified oil and artificial raw materials.

　　DO SPRITZ IT ON YOUR HAIR spray perfume on your hair.

　　Perfume actually doesn’t last too long on dry skin, according to Kurkdjian and as you sweat the natural oils destroy the fragrance.

　　Kurgian pointed out that perfume can’t stay on dry skin for too long. When you sweat, natural oils will destroy the fragrance.

　　You can combat this by using the matching body lotion or making sure your moisturiser isn’t scented so it doesn’t interfere.

　　You can prevent the fragrances from interfering with each other by using a body lotion that matches the scent of perfume or a body lotion without perfume.

　　If you want to ensure longevity, mist your scent lightly on your hair or on a scarf.

　　If you want perfume to last a long time, you can spray it gently on your hair or scarf.

　　’Because they move with the air, it helps with the diffusion of the scent,’ he explained.

　　He explained: "Because the hair and scarf are fluttering in the wind, it helps to diffuse the fragrance."

　　If you are putting perfume on your skin, target spots that are exposed to the air.

　　If you spray perfume on your skin, you’d better spray it on the body parts exposed to the air.

　　It’s no good putting it on pulse points such as the wrists and inner elbows if they’re covered up.

　　If the wrist or elbow is covered with clothes, it is useless to spray perfume on the pulse beating place such as the inside of the wrist or elbow.

　　(English source: Daily Mail Translation & Editor: Dany)

　　CCTV News:At 8 o’clock on the morning of December 16th, the website of the Supervision Department of the Central Commission for Discipline Inspection released a message saying that Cao Baijun, the former director of the Fourth Bureau of the International Liaison Department of the CPC Central Committee, was suspected of serious violation of discipline and was currently under organizational review.

　　　　　 Cao Baijuan was born in Nanjing, Jiangsu Province in April 1954. Graduated from Shanghai International Studies University (now Shanghai International Studies University) in 1975, majoring in German, and worked in the International Liaison Department for a long time.

　　In 2009, Shanghai International Studies University celebrated its 60th anniversary. As an alumnus, Cao Baijuan returned to Shanghai to have an exchange meeting with German teachers and students. Cao Baijuan recalled his college life. He said: "There should be three problems to be solved in college. First, study hard. Second, deal with interpersonal relationships. In addition, we should establish correct political beliefs, outlook on life and values." Referring to his life experience, he said that when he graduated from university, his goal was to become the best translator in China. To this end, he did a lot of exercises and read a lot of books. "The goal is very single, so it is easy to succeed." He described himself like this.

　　According to public information, Cao Baijun worked in the International Liaison Department of the CPC Central Committee from 1975 to 1982, and was responsible for the business of this department and German-speaking countries in Europe. In 1982, he won a scholarship from the Adenauer Foundation in Germany, and studied in the Institute of Political Science of the University of Heidelberg, Germany. The instructor was Klaus von Baimer; After returning to China in 1985, he served as the director of the German Department of the International Liaison Department of the CPC Central Committee; During this period, I participated in the reception of famous German politicians visiting China, such as johannes rau, La Fontaine, Scharping, Birna, Barr and others, and served as the chief translator. In 1992, he went to UCLA for short-term study.

　　From November 1992 to August 1993, he served as the director of the Planning Commission of Shanghai Pudong New Area Government. From August 1993 to May 1999, he served as deputy general manager and general manager of China Hualian International Trade Company; In May 1999, he served as the director of China Economic Liaison Center and concurrently served as the general manager of China Hualian International Trade Company; In 2007, he began to serve as the director of the Fourth Bureau of the International Liaison Department (Africa Bureau) until he left office.

　　After leaving office, Cao Baijuan became a company consultant. In August, 2017, a company published a news in official website that a Spanish representative came to visit and investigate, accompanied by Cao Baijuan, a senior consultant of the company. This was the news of Cao Baijuan’s last public appearance.

　　　　　 It is worth mentioning that from July 2 to August 31, 2016, the Central Fourth Inspection Team conducted a special inspection of the International Liaison Department. During the inspection, the inspection team found some problems reflected by the cadres and the masses, mainly: the "four consciousnesses" are not strong enough, there is a gap in implementing the central decision-making and deployment, and it is not enough to respond to the central concerns and take the initiative; The party building work is weakened, the ideological and political work is weak, the rectification of the party’s mass line education practice activities is not in place, and the implementation of attendance system is not strict; Strictly administering the party in an all-round way is not strong enough, supervision and discipline are loose and soft, and investigation and punishment of some obvious violations of discipline are not in place; There is not enough transparency in the selection and appointment of cadres, and there is a phenomenon of "discussing personal relationship", and the training and exchange of cadres are not enough; Spiritual behaviors that violate the eight central regulations still occur, such as office buildings, overseas delegations, official receptions, etc., and individual subordinate units illegally distribute benefits and subsidies; The management of state-owned assets and funds is lax, the management of real estate rental is chaotic, and there is a risk of clean government. At the same time, the inspection team also received reports of problems involving some leading cadres, which have been transferred to the Central Commission for Discipline Inspection, the Central Organization Department and other relevant parties for handling according to relevant regulations.

　　It is unknown whether Cao Baijun is included in the problems involving some leading cadres mentioned in the inspection report.

"Congratulations on lending 500,000 yuan, and customers can’t keep up." Xiao Bo (a pseudonym), who claimed to be an intelligent outbound service provider for telemarketing, updated his circle of friends with a screenshot of a customer’s successful lending. In Xiao Bo’s circle of friends, there are many similar "success stories". Xiao Bo claims that his telemarketing robot can make more than 1,000 calls in a single day, and the connection rate remains at 30% or even higher, and can avoid supervision and prevent titles.

Are you still bothered by harassing calls about selling loans and POS machines?

From late October to November, 2021, The Paper reporter found that the chaos in the telemarketing industry still exists. The technical model of "outbound call system+telemarketing robot" claims to be able to accurately dial the special line and mark the customer information, and evade the supervision of communication operators through technology; Behind it are hidden behaviors such as illegal trading of personal information and illegal sales of POS machines.

The so-called "anti-sealing" call-out system for electric sales

Telemarketing is a sales method relying on telephone, which contacts customers through special telephone marketing numbers to complete product promotion, quotation, transaction, etc., but this method is often easy to cause harassment to users. In the media reports, there are many cases in which telephone users are often disturbed by receiving telemarketing calls. In recent years, the Ministry of Industry and Information Technology and the three major operators have taken measures such as "high-frequency call blocking". However, with the application of intelligent voice and other technologies, the intelligent outbound calling software system, which claims to be able to make a large number of calls a day and "prevent blocking" (prevent blocking), still makes users hard to prevent.

A recent survey in The Paper found that some telemarketing software used "anti-sealing" as a gimmick to attract customers, and all kinds of "anti-sealing robots" gradually became popular in the market.

In Baidu Post Bar and Tencent QQ, the keyword "electricity sales" is searched, which shows a lot of information about "electricity sales software". The reporter randomly joined a QQ group named "Outbound Call System for Telemarketing", with more than 1,000 members and an account named "Chamber of Commerce for Telemarketing Systems" posting various promotional information related to Telemarketing from time to time in the group. "electricity sales card", "electricity sales App" and "electricity sales anti-sealing system" ……

The sales information in the group claims that the services provided can cover the whole industry such as finance, collection, loan, insurance, health care, drinks, auto insurance and games.

The reporter randomly added the WeChat of Xiao Bo, a telemarketing intelligent outbound service provider, from the QQ group. He asked the reporter what business he wanted to do, saying, "Let’s see if we can do it. Now the telecom fraud investigation is strict." After confirming that it was a "campus loan" business, he enthusiastically introduced his products and sent a price list, including a set of real-life speech made by 300 yuan, and a robot package divided into basic version, premium version and agent version according to different price points and specifications. During the conversation, Xiao Bo said that most of his clients are selling financial stocks, loan insurance and POS machine sales, all of which can be "sealed".

In his description, the "anti-sealing robot" does not need any calling cards and auxiliary equipment, and the outbound call system purchased together will use the group call line to dial the number. Regarding the reporter’s question that "making too many calls will not be seized", Xiao Bo replied that a certain line will inevitably have complaints every month, but as long as it reaches the upper limit of the complaint rate, it will stop the line and replace it with another one, so as to prevent the system purchased by customers from being blocked. He also mentioned a new business to be launched soon-an anti-sealing App for electricity sales. In the promotional picture of the App, the words "the three major operators’ Puka seconds turn white list and the high frequency does not seal the number" are placed in the most conspicuous position.

In order to further dispel the reporter’s doubts, Xiao Bo added, "We are first-class landing line operators and all cooperate with operators."

He Zheng (a pseudonym), another service provider who claimed to be engaged in the research and development of the telemarketing system for 6 years, explained to reporters that the telemarketing robot business on the market now basically adopts the "line+system+service" model. Buyers only need to use the account they provide, and they can enjoy a full set of services, "including technical support, carrying lines and after-sales."

In the 1 minute and 22 second recording of "Loan Talk" he sent, a customer on the other end of the phone in love women, who claimed to be a "customer service representative of a bank", indicated that he could handle a loan of 3-5 million yuan and "pay it back as you borrow it". In this conversation, the customer service representative repeatedly said that he was a staff member of "a bank credit center" and asked about the occupation of the telemarketing customer, the loan and insurance business he handled, and "whether there is a house or a car under his name".

He Zheng said that the so-called "bank customer service representative" bought their telemarketing system, recorded it in advance, and combined it into a complete sales talk according to the matching of the system. The customer thought it was a real person and was constantly "promoted", and might place a loan order. But in fact, they don’t know whether this "bank customer service representative" is a bank staff member or a telecom fraudster.

The "material dealer" in the dark of the electricity sales industry

In the telemarketing industry, an important part is to obtain customer information resources. The illegal trading of personal information also breeds in the dark.

After the reporter joined a QQ group, a "supplier" who claimed to specialize in health care lines (the person who provided information such as the user’s phone number) sent a message in the QQ group saying that he obtained the information of consumers who bought a health care book in TV shopping programs and then sold it to the telemarketing team or system service provider who promoted health care products. In the screenshots he sent, these consumers are distributed in different provinces such as Shandong, Henan and Zhejiang.

Compared with system service providers, "material suppliers" are more cautious. They usually don’t directly give contact information such as WeChat or telephone, and they will communicate further after confirming that the other party is an "intended customer".

In a chat with a "supplier" named AZY, the reporter learned that most customer resources are divided into "AI materials" and "hand-stripping materials". "AI material" is provided for electric sales robots, while "hand stripping material" is provided for employees who make phone calls manually. According to the feedback rate of dialing, the prices of the two "materials" are also different. Generally speaking, the feedback rate of "hand stripping" is higher than that of "AI material" and therefore the price is higher.

According to the price standard sent by AZY, 600 yuan RMB can buy 10,000 pieces of AI materials or 1,000 pieces of user information. These materials are usually replaced by different pinyin abbreviations, such as the special line for investors, which they call "GM powder", and the online loan, which is called "Wd".

There are many "anti-pit and anti-second-hand material merchants" posts in Baidu Post Bar. Some familiar "material merchants" will add WeChat to each other and set up their own WeChat groups, in order to expand or stabilize their sources of "materials".

In the investigation, the reporter found that in order to be more concealed, the transactions between suppliers and buyers often shift from WeChat to other more private online trading platforms. The line operator "AXY" chose an overseas chat software called "Telegram" to complete the transaction with the customer. After failing to reach a transaction with the reporter, "AXY" immediately closed his QQ space.

How to deal with the chaos of electricity sales

In recent years, the phenomenon of electricity sales has been repeatedly concerned and rectified.

In 2019, the central bank issued document [2019] No.85 "Notice of the People’s Bank of China on Further Strengthening the Management of Payment and Settlement to Prevent New Crimes in Telecommunication Networks", pointing to the chaos of telephone sales of POS machines. At the same time, a number of payment institutions issued a notice on strictly prohibiting online sales and electronic sales of POS machines. However, the circle of friends of service provider He Zheng is still full of sales records of a large number of "POS machine" sales customers. When the reporter asked about the POS machine sales business, he did not show him any business license in the financial industry.

According to media reports, the sales scam of POS machines has already become a high-incidence area for complaints. Telephone sales mostly attract customers to use their products with "low rate and free delivery", but after the user places an order, there will be various charges including activation fee, deposit, service fee and so on. The reporter’s search on the Internet also found that many deceived users reported that they could not get the account after receiving the POS machine, and even were blacked out directly by the salesman.

In May this year, the Consumer Protection Bureau of China Banking and Insurance Regulatory Commission issued Circular No.8 of 2021, "Circular on Cases of Ping An Bank’s Telemarketing of Physical Products Infringed on Consumers’ Legal Rights and Interests" (hereinafter referred to as "Circular"), which informed the case that Ping An Bank cooperated with a third party to sell physical products by telephone and infringed on consumers’ legal rights and interests.

According to the "Circular", in the spot check of 60 physical products sold by Ping An Bank Credit Card Center, 53 businesses were illegal, accounting for 88.33%.

Fu Liang, a telecom analyst, told The Paper that at present, the management of the domestic electricity sales industry has not yet formed a complete norm. "Many links have not been (completely) opened." If the management standards between relevant departments cannot be unified, there will be barriers to the management and rectification of the chaos of electricity sales. Even if users find their personal information leaked or traded, it is often difficult to find a "channel" for complaints and handling.

Fu Liang also pointed out that operators are the primary link to ensure that users’ information is not leaked. They often have their own strict operating norms, but they cannot completely avoid the possibility of leaks in huge business branches. Moreover, in this highly developed network era, many personal information is in a "semi-public" state.

He believes that in the use of various scenes in daily life, such as telephone numbers and names, information is constantly used and exchanged, and it is difficult to completely quantify whether it involves "privacy disclosure". "If there is an improper transaction of user information, no matter where it happens, it is an illegal act."