Everything you want to know about Shiseido is here!
I believe that every exquisite beauty who loves Japanese skin care is filled with bottles and cans of Xu Sanduo’s products on the dresser.
In fact, "Xu Sanduo" is SHISEIDO, one of the four major cosmetics groups in Neon. Because of its similar pronunciation to "Xu Sanduo", it is called "Xu Sanduo" by many skin care lovers.Speaking of the origin of Shiseido’s name, it is named after "the most precious thing in the Book of Changes", which means praising the virtue of the earth, giving birth to new life and creating new values. This name is the reflection of Shiseido’s corporate image, which combines the aesthetics and consciousness of the East with the technology and business practice of the West, combines advanced technology with traditional ideas, and interprets the implicit oriental culture with western culture. In 1872, Shiseido founded the first western-style dispensing pharmacy in Ginza, Tokyo, Japan. In 1897, the cosmetic water named EUDERMINE was scientifically developed based on western pharmaceutical prescriptions. Because of its liquid color, it is called Shiseido Red Water, which can infiltrate the cuticle of the skin and prevent dryness, thus opening the first page of the development of the cosmetic industry. Until today, this product still uses the improved formula. Since then, Shiseido has been devoted to the research of beauty and hair, and has developed many innovative products and beauty methods.
Brand history
In 1916
one
Shiseido opened its first Shiseido R&D center in Japan, and also opened an independent cosmetics store next to the pharmacy in Ginza, Tokyo. Its interpretation of beauty is unique, that is, it is committed to embracing and redefining beauty from the inside out by discovering new technologies and methods. The developers try to convey the idea that beauty awakens from the five senses. Thanks to this investment, there are now research centers in China, Thailand, the United States and France, and they are also in the leading position in the field of skin care and basic research of dermatology in the world. In terms of product quality, testing and formula, Shiseido has always pursued a high standard position. Any natural ingredients are purified according to the company’s own high standards before being added to the formula. In 2000, Shiseido factory was certified by ISO14001. The company has always responded positively to maintaining environmental awareness.
In 1919
three
In early 1919, Shiseido opened a gallery, which is one of the oldest existing art galleries in Japan, and has held more than 3,100 exhibitions. Shiseido continued to support and cultivate enterprising Japanese artists, many of whom made great contributions to Japanese art later. In the development of Japanese photography art, the founder Fukuhara family is also closely linked with it. In Guachuan, since 1978, Shiseido Art Museum has exhibited a large number of contemporary art and design works collected by Shiseido.
In 1917
2
At the same time, in order to get more beautiful inspiration, Shiseido seeks beauty and shares beauty in art, and has been committed to cultivating and developing artistic career, thus making products have excellent design quality. Since the founding of the family, the desire to integrate art and science has been particularly strong. Over the years, their great appreciation of European art, culture and design has also been reflected in the image of Shiseido. In 1917, the "seven-color honey powder" was introduced, and the octagonal packaging inspired by decorative art was adopted. This is Shiseido’s first product that allows customers to match according to their skin color, not just whitening. Launched Shiseido’s first real perfume, "Toona sinensis", which was prepared by a Japanese perfumer. Its fragrance comes from traditional Japanese flowers such as camellia, plum and wisteria, and it is packed in high-quality carved glass bottles.
In 1983
one
In 1983, the Huachun Contemporary Poetry Award was held for the purpose of "enhancing the communication power of words to beauty".
In 1986
2
In 1986, Shiseido held an advertising art exhibition at the Paris Advertising Museum. Shiseido’s design works combine Japanese traditional culture with French new art and decorative art, and have unique visual expression, which is appreciated by many French people.
Hua chun
It is interesting to say that Shiseido’s cultural confidence in Hua Chun is far more than that.Shiseido pays attention to the excavation of product culture and regards design as a philosophy, thus challenging its wisdom and soul.Hua Chun magazine is an internal magazine founded by Shiseido. It was once selected as the top magazine in the world. Following the cultural concept of the integration of East and West, Hua Chun has also become the expression of Shiseido’s corporate culture, with far-reaching influence in European countries. That is, after Hua Chun magazine appeared, Shiseido turned its energy to product packaging design, poster design and related design fields, recognizing that high-quality products need corresponding image packaging. "Hua Chun" takes the girl as the main character image in the picture, with prominent Japanese names, romaji’s publication name and issue number on the cover. The layout design of the advertisement has both western avant-garde visual image and Japanese elegant style, which has a very strong influence and a good visual image. However, Shiseido’s Huachun magazine does not focus on its own products, but also pays attention to the development of the whole cosmetics industry, including popular periodicals, magazines, fashion and tourism in Japan and abroad, and also includes articles by famous contemporary writers, which has become the characteristics of Shiseido’s Huachun magazine. [1]
It can be said that Shiseido in my eyes is a brand that combines art, imagination and inspiration. After 150 years of tortuous development, Shiseido has now become the largest cosmetics brand in Asia and has great influence in the international beauty market. [2,3] Today, Shiseido has carefully divided the cosmetics market, created many product branches according to different consumer needs, and formed a perfect brand matrix. From the top brand THE CINZA (Ginza), which contains SHISEIDO’s cutting-edge technology and beauty technology and is only distributed in Japan, to the high-end counter brands CPB (Key to the Skin) and Shiseido (Shiseido) suitable for women with higher economic ability, and then to AUPRES (Aupres), PURE&MILD (Bomei) and URARA (Youlai) for the mass market. In addition to different pricing strategies, Shiseido’s many product branches have different main functions. For example, BIO-PERFORMANCE and BENEFIANCE focusing on anti-aging, WHITE LUCENT focusing on whitening and blemishing, ELIXIR focusing on collagen, etc. With the change of people’s consumption concept and the rise of "other economy" in the cosmetics market, Shiseido has also developed MEN (men’s series) specially for men.Market segmentation has expanded Shiseido’s product coverage in China, met the needs of more consumers, and enabled consumers of different genders, ages and skin types to find the right product among Shiseido’s many brands, which provided an important foundation and guarantee for Shiseido to enter the cosmetics market in China on a large scale. [2]
To put it simply, Shiseido China currently has more than 20 brands, including hairdressing and beauty instrument brands, mainly as shown below.
Award-winning research of IFSCC conference
The success of Shiseido is not only related to its strong artistic color and the group’s many brand branches designed for different skin care demands, but also the excellent technology.And this is also the most concerned part of the party, the raw material party and the efficacy party.
How strong Shiseido’s science and technology is, we can directly see its award-winning times in IFSCC. Founded in 1959, the International Federation of Societies of Cosmetic Chemists (IFSCC) is an international organization composed of cosmetic technologists from all countries and regions in the world. Headquartered in new york, it has been joined by 74 countries and regions with more than 16,000 members (from January 2018 to now). Japan officially joined IFSCC in 1962. IFSCC has carried out various activities to improve cosmetic technology and develop safe and practical cosmetics. Among them, IFSCC conference is a large-scale event where cosmetic technicians from all over the world gather to publish the latest research results. The Congress is divided into congress (formal congress) held in even-numbered years of Gregorian calendar and Conference (intermediate congress) held in odd-numbered years of Gregorian calendar. From 1976 to 2019, Shiseido won 28 awards in formal and intermediate conferences. This overwhelming number of awards proves that Shiseido has superb technical strength that other companies can’t match, and directly ranks first in the world in terms of awards.
This is part of the screenshot I took from Shiseido Group’s corporate intelligence website:
And the catalogue of more than 600 invention patents is also very attractive?
Many of the research contents here have penetrated into the above-mentioned brands. Next, starting from this article, I will give you a detailed description of these brands that embody the core patent or black technology skin care concept. In the first issue, let’s start directly with the brand name Shiseido ~
Four sections of skin care
I have divided our favorite skin care demands into four sections, namely, moisturizing, repairing, whitening and anti-saccharification (anti-aging). Each section has Shiseido’s skin care concept, new ingredients and corresponding star products. You are welcome to help yourself and enjoy eating ~
First, moisturizing
Speaking of moisturizing, I don’t think there is any sentimental brand-Shiseido’s most classic red water (red honey dew essence water) is a more representative product. It was produced in 1897 and is the first product of Shiseido. So far, it has been updated to the eighth generation. The formula is basically a humectant, which is indeed a great breakthrough and cutting-edge product for the cosmetics market a hundred years ago, because pure glycerin will have a more obvious sticky feeling when used on the face, but it will not; Today, with the soaring demand for advanced skin care, this lotion basically does not cover the ingredients that meet its demands, so you can regard it as a high moisturizing lotion or a water-based lotion. There’s something to say here, so don’t underestimate the role of moisturizing! In fact, moisturizing, cleaning and sun protection are done well, and basically skin care is more than half successful, because it ensures the health of the skin barrier and can resist the invasion of photoaging and other harmful factors to a certain extent. When the skin barrier is damaged, you have to cry like a moisturizing ingredient for help. Especially for dry and sensitive skin, moisturizing is an important prerequisite.
Its bottle body is antique, very textured, and it is elegant red, which looks like a symbol of joy, high spirits and good luck in the new year. Shui Yang texture, whether dry or oily, can hold, giving people a moist but not greasy feeling. It is a very well-balanced water in terms of effect and skin feeling. This kind of feeling is like you want to drink a cup of milk tea. You are afraid of the mellow sweetness of 5 cents, and you don’t like the blandness of sugar-free, and it gives you a feeling of "just right" just like 3 cents.My personal experience is as follows: the first snow fell in Jiangcheng in late January, and a few drops of red honey dew were dropped in the air-conditioned room, and then gently massaged and absorbed, so that the skin could feel the tenderness surrounded by moisture, and the skin color would instantly brighten and shine after hydration, even if the essence and cream were no longer applied, it would not be dried. Although the skin color did not change the next morning, the moisture fullness was still online.
Second, repair
Repair, a topic that is emphasized every day, are you sure you have done all the repairs? From the end of the 21st century to the present, I have always emphasized the importance of immune barrier with you. Zhihu’s articles "Guide to Selecting Sensitive Muscle Cream" and "Accidental Poxville Scheme" are the best proof. If you don’t know about immune barrier, you can go and have a look at these two articles. You only need to know that Langerhans cells (etc.) are involved in regulating the immune barrier, and β -glucan is the component that promotes its activity. After the immune barrier is repaired, the skin can better resist oxidative stress, inflammatory reaction and even aging. At this time, you may have to ask questions. What does all this have to do with Shiseido?
In fact, over the past 140 years, Shiseido has been trying to find ways from the inside of the skin to enhance the skin’s resistance and ability to overcome problems, including the study of skin immunity. [4]
After more than 20 years of joint research with authoritative scientific institutions, they have confirmed the relationship between immunity and skin health. Just as the body’s immune system can protect us from dangerous foreign invasion, skin also has its own immune system, which can resist the increasingly severe environmental threats, various pressures and aging phenomena. When your skin has problems that can’t be cured by any method, it’s time to rebuild your skin immunity! The key is Langerhans cells, which can be called the commander of skin immune system.
As one of the immune cells, it is mainly responsible for managing the skin’s defense and self-healing functions.We can understand it as the guardian of the skin against external germs. If there are bacteria or some other immunogenic substances that want to harm our skin, it can raise its shield to meet those cells. Its mechanism is to capture and treat the antigen invading the skin and pass it on to T cells, resulting in an immune response. Human version: It detects substances invading from the outside, and gives a warning to other cells, so that they can play their respective immune functions. When the immunity is high, you won’t notice that it is working. However, when the function of Langerhans cells decreases, the immunity will be weakened, and then the skin will be allergic, inflammatory, aging, dark yellow and so on. Based on this major research and development achievement, it has made "Red Kidney" in the skin care industry today.
As the world’s first "immune essence", Shiseido has exclusively developed a heavyweight ingredient that can enhance the function of declining Langerhans cells.ULTIMUNE compound ingredients. It contains β -glucan extracted from baker’s yeast, Bulgarian rose water and Shiseido original moisturizing ingredient Moisturizing Pool, which can enhance the skin vitality of Langerhans cells, strengthen our immune barrier, and make the skin have better defense and compression resistance in the face of external injuries, thus making it less prone to problems such as dryness, pigmentation, wrinkles and relaxation.
I still want to talk about β -glucan here, which is a favorite ingredient of Shiseido Group. Not only Shiseido, but also other brands, such as ISPA and Oprah, can see it. I described it in detail in Zhihu’s article "Accidental pox muscle", which can activate Langerhans cells and induce their local or systemic immune and repair functions. The mechanism is that there are receptors on the surface of Langerhans cells that specifically respond to β-glucan, thus stimulating Langerhans cells and activating immune response. Experiments show that β -glucan can also increase the moisture retention of skin and weaken the damage of surfactant to skin. Improve the renewal speed of stratum corneum; Improve skin tightness; And the efficacy of preventing skin oxidation caused by ultraviolet radiation. This formula not only makes the skin get simple repair, but also protects against all kinds of harmful substances and pressures in advance.
Last year, this classic red kidney product once again ushered in the third generation upgrade, and once again applied the research on the unique perspective of immunology, giving me a bright feeling.What do you say? This time, I actually improved my immunity directly by promoting microcirculation.
Microcirculation refers to the blood circulation of capillary network between arterioles and venules, which is the process of material transport and metabolism between blood and tissue cells. It will affect nutrient absorption, immune response, skin color, body temperature regulation and transdermal absorption, so microcirculation plays an important role in supporting various functions of the skin. Capillary network system, as the final regulating and functional unit of metabolic regulation, is the basis of realizing microcirculation regulation. Once the capillary network is blocked and the immune cells are inactivated, the skin’s immunity will decline, and it is easy to receive external stimuli to cause allergies. In this way, a logical relationship is formed: poor capillary microcirculation → decreased activity of skin immune cells → decreased immunity → stress response to external stimuli: redness, inflammation, etc.; Pushing back and promoting skin microcirculation is equivalent to mobilizing the activity of immune cells and improving skin immunity, so as to better resist external stimuli, such as inflammatory reactions produced by the skin, and then improve redness.
The third generation of red kidney adopts a brand-new red pulse microcirculation technology, which can accelerate the skin microcirculation, strengthen the activity of immune cells, improve our skin’s immunity and resistance to external stimuli. It’s just like when it’s cold, we can accelerate the blood circulation inside the body by doing more exercise, so that the body can be warmed up, and the cold-proof ability will be significantly improved, which is much more powerful than staying in an air-conditioned room and getting warm by external forces! The whole process of "skin care+immunity enhancement" is completed by Langerhans cells and NK cells. Langerhans cells, which I have mentioned to you before, and natural killer cell are also important immune cells in the body. By killing some irritating substances, such as microorganisms (viruses or bacteria) that reduce our immunity, it can participate in hypersensitivity and autoimmune diseases in some cases. We can think of it as a policeman with a gun, who can remove the bacteria or other harmful substances from the outside. In addition, it can repair aging cells and rejuvenate them. These two friends support our healthy skin, so now you can play "cellular immune repair"!
This essence still extends the refreshing skin feeling of the second generation. The translucent gel texture may feel moist at first, but it is quickly absorbed by the skin and then becomes matte. I used it basically without burden last summer. Although denatured ethanol is added to it, the skin will not feel stimulated and dried, and there is still some cool feeling. A few hours after using it, the redness of my face can be gradually calmed down, and the subsequent brushing is also very reassuring and easy, just like taking a dose of cardiotonic in advance, giving me the feeling of "having nothing to fear"? Although this metaphor may be a bit inappropriate, I want to say that its stability and repair effect is really satisfactory.At the same time, this feeling of striving for progress in stability is also reflected in its fundamental point-immunity. I obviously feel that the frequency of my acne has decreased in the future. Is it also a good testimony?
Third, whitening
Speaking of Shiseido’s patented whitening ingredients, I think thrombotic acid +4MSK must sit firmly in the first place in C.
As a matter of fact, Shiseido also has a patented formula about coagulation acid at home, as shown in the following figure [5]. In 1998, Shiseido proved that coagulation acid combined with hyaluronic acid can improve rough and dull skin. However, many documents show that the whitening effect of coagulation acid alone is not obvious, and it may be necessary to use other ingredients to achieve better whitening effect. Its core effect is to dilute the pigment deposition after inflammation.
Then there is a lot to say about 4MSK. Shiseido began to study the ingredients against melanin in the 1980s, specializing in whitening for 40 years, and began to study the whitening effect of 4MSK in 1993, and has been creating 4MSK for nearly 30 years. In 2003, 4MSK was certified by the Japanese Ministry of Health and Welfare, and the first generation whitening essence of Shiseido came out. From 2005 to 2019, 4MSK won six Japanese patents. In 2020, the whitening essence-cherry blossom bottle has been updated to the seventh generation. I have to say that Shiseido always surprises us in the times.
Speaking of 4MSK, its structure is similar to salicylic acid. Shiseido Institute found that the whitening mechanism of 4MSK is to inhibit melanin, inhibit the activity of arginase, correct abnormal keratinization (such as inhibiting the differentiation of keratinocytes caused by ultraviolet rays), and metabolize the melanin that has been generated, which is a whitening component with a very complete pathway.
The research on melanocytes shows that it can significantly inhibit melanin production at the concentration of 3×10-4mol/L, and it has full potential compared with the existing whitening active ingredients. Secondly, through in vivo tests, it is confirmed that the test product containing 1-5%4MSK has a concentration-dependent defense effect on pigmentation caused by ultraviolet rays. No abnormal skin phenomenon was found during the whole experiment, so it can be considered that 4MSK is safe and effective as a cosmetic ingredient. The above in vitro studies confirmed that 4MSK has a direct inhibitory effect on the production of melanin, and also has an effect on the proliferation and differentiation of keratinocytes. These two effects have defensive effects on the production and release of melanin, which leads to excessive deposition of melanin in skin. However, the in vivo test results show that 4MSK has excellent defense effect on pigmentation caused by ultraviolet rays, so it is considered that:4MSK can also play a good role in solving the problems of pigmentation, freckles and dullness of skin melanin. [6]
4MSK is already so strong in theory, but what is the actual effect? Let’s go directly to the seventh-generation cherry blossom bottle to check it.
I haven’t used the old cherry blossom bottle before, so I just left it out. In this newly upgraded cherry blossom bottle, although there is no coagulation acid component, the concentration of 4MSK has been fully doubled. With the extract of Pyrola rubra+Potentilla chinensis root extract+vitamin C derivative, the production of melanin can be better reduced. What, didn’t you say all-round whitening? Since 4MSK can brighten the skin and reduce the spots, what should I do with the yellow gas and acne marks left on my face? Don’t be afraid, the product also has a hidden core ingredient to help you solve this trouble-including Tokyo cherry leaf extract (Yoshino Sakura). It has excellent anti-oxidation and anti-saccharification effects, which can better target dullness and yellow gas, and its extra anti-inflammation can also repel acne bacilli and acne marks, so don’t be afraid. Finally, the ace ingredient is sea water fairy extract, and its addition amount is not low, which can also inhibit the front melanin to a certain extent: pro-opioid cortisol (melanin: am I easy? I, so many people want to intercept me, can I quit? ! ), but also can converge the skin and regulate oil secretion. There is less oil on the face, the pores become smaller, the yellow gas is waving, and the clean and white face is just around the corner.
With the whitening blessing of many gorgeous ingredients, it is no wonder that consumers can feel the change of skin color in only 2~4 weeks. Maybe you use too high a concentration of vitamin C and alcohol A, which have strong short-term effects, but the effect of cherry blossom bottles will not drop at all after long-term use, and the most important thing is that they are much milder. The product is still the refreshing skin feeling of Japan, with white emulsion texture and strong ductility, which can be wiped on the face quickly and then absorbed by the skin like water, with pleasant fragrance, giving people a superior skin care experience. In my eyes, this essence is an out-and-out "skin palette" essence. During my short-term use for half a month last year, I first felt that the fragile and sensitive parts around my lips became more uniform. A month later, with strict sun protection, the yellow gas on the face has begun to decrease; After three and a half months, that is, after two empty bottles, the skin color finally began to brighten and whiten significantly, and it also had some extra red repairing effects, which was an unexpected joy.The sense of transparency pursued by the Japanese, that is, the skin color is even, the yellow gas is less, and the white ground is clean. I think the cherry blossom bottle has brought me to it!
Fourth, anti-saccharification
Do you think that the more you eat sweets, the easier it is to get acne? Do you feel that after eating particularly sweet and greasy food, your skin becomes a little darker? When eating more vegetables and reducing carbohydrate intake, do you feel that your skin is lighter? These are all derived from the "saccharification" of the skin.
Saccharification reaction, also known as non-enzymatic glycosylation (Neg) reaction, refers to the non-enzymatic condensation reaction between carbonyl groups on reducing sugars (such as glucose) and free amino groups on macromolecules such as protein, lipids or nucleic acids. The stable covalent adducts produced by the NEG reaction are collectively called advanced glycosylation end products (AGEs). When it comes to the harm of saccharification to skin, it mainly causes pigmentation, accelerates aging, activates inflammatory pathways, and causes dryness, which leads to fragile barriers. Therefore, anti-saccharification should be put on the skin care agenda as soon as possible.
Shiseido has been working hard in skin care technology, and this time it is Shiseido Yuewei Zhigan series "Sugar Control Cream" that helps us to alleviate the anxiety of "dessert attack". It adds the extract of Sunrise Honghua and compound plant extract VP8, which can reduce the damage of saccharification and free radicals (oxidation) from the perspective of anti-oxidation and anti-saccharification, and make use of the latest research results of skin neuroscience. Here, let’s start with the achievements of skin neuroscience.
This achievement was presented by Shiseido at the annual meeting of global neuroscience in October 2019 and the 44th annual meeting of Japanese research dermatology in November. In this brand-new research, Shiseido put forward the following arguments: 1- Shiseido has established a visualization nerve fiber technology, which can visualize nerve fibers at a depth of 2mm including the deep dermis; 2- Peripheral nerve fibers will decrease with age; 3- Some components (neurons) of peripheral nerve fibers can stimulate fibroblasts to synthesize collagen, thus improving skin elasticity.
In the subsequent research, Shiseido tested the efficacy of multiple plants to stimulate sensory neurons, and finally found a variety of plant linking proteins from compositae plants that can activate the growth of sensory neurons, which can act on TRPV1 channels (the Nobel Prize-winning theme came again last year! ), thus activating sensory neurons, so it perfectly connects with the third logic just now. With the regeneration of neurons, it can better stimulate fibroblasts to synthesize more collagen, thus improving skin aging. And this is also the origin of the essence of the rising sun safflower.
Safflower extract is a kind of compositae plants. Shiseido research found that it can improve skin quality, and reduce the generation of AGEs to reduce saccharification damage, thus improving the dark yellow, roughness, pores and other problems caused by saccharification, that is, it can achieve anti-aging effect from the perspective of anti-saccharification. As a classic soul formula of Shiseido, VP8 contains the familiar olive oil leaf extract, tea extract, etc. Together, it can effectively delay the skin protein aging and the hardening and fracture of collagen fibers, and reduce the skin fire. Flavonoids and polyphenols contained in VP8 can also play a certain role in antioxidation and anti-saccharification. As I just mentioned in the skin neuroscience, the linked proteins in compositae plants can promote the regeneration of sensory neurons and improve aging, while Yuewei anti-icing cream adopts the latest research of Shiseido, which maximizes the effect of the extract of Safflower Rising Sun and VP8 in promoting the regeneration of sensory neurons and helps us to keep the skin young from the skin neuroscience level. The addition of 4MSK also strengthened the effect of anti-icing and whitening skin.
In addition, the nerve induction based on skin affects the accuracy and speed of skin self-repair.Shiseido has also developed Reneura Technology++™+technology applied to sugar control cream. This technology uses a microsphere powder that can respond to the changes of skin state in real time. Just like monitoring, it uses the nerve induction technology to wrap these skin care ingredients, so that they can take effect slowly and make the product paste have a skin-friendly and clear skin feeling.
The texture of sugar control cream is moist but not greasy, and it is milky yellow ice cream texture. After being absorbed, the skin has a natural luster (not glossy), giving people a feeling of vitality and brightness. When used personally, especially when used together with cherry blossom bottles, the skin permeability and uniformity have been significantly improved, and the yellow gas has dissipated a lot. If you persist in using it for several weeks, the skin still has obvious tension and contraction. Of course, if the skin is tolerant, you should also cooperate with high concentration.
OK, some technologies of Shiseido Group-Shiseido brand in this issue are over. Let’s meet again next time!
References:
[1] Feng Zhongqiang. Enlightenment of Shiseido illustration historical change on contemporary advertising design [J]. Charming China, 2013(32).
[2] Tang Xiaoqing. Analysis of the localization of cosmetic brands oriented by consumer demand-taking Shiseido as an example [J]. Journalism Research Guide, 2020 (19). Doi: 10.3969/j.issn.1674-8883.2020.19.101.
[3] Yan Chang. The development history of Japanese cosmetics brand giant Shiseido [J]. Youth years, 2018(8).
DOI:10.3969/j.issn.1007-5070.2018.08.419.
[4] Overcoming Injury, Tough and Beautiful Shiseido launched the world’s first essence for improving skin immunity [J]. Friends of Health, 2014(12).
[5] Kenji Kitamura, Taiyi Zhongshan. Shiseido Company’s patent on the formula of coagulation acid (continued) [J]. Daily Chemical Science, 1998(5).
Fujiwara, Rumeiko, Sato Jie. Efficacy of potassium 4-methoxysalicylate (4MSK), an effective whitening ingredient [C]. 2010.