【Chexun. com reported】 Recently, the first model of HarmonyOS Zhixing’s last "world" Shangjie H5 was officially released, and the Shangjie synchronization official announced that the new car will be pre-sold on August 25th.

　　For HarmonyOS Zhixing, Shangjie is not only the last link to make it form a "fist power" completely, but also the key to make it burst into greater energy in China auto market. Previously, the photo of Yu Chengdong, managing director of Huawei and chairman of BG, and Jia Jianxu, president of SAIC, driving the Shangjie H5 together triggered a heated discussion on the Internet. This high-level interaction shows that both sides attach great importance to Shangjie H5!

　　Are you ready to challenge the Red Sea and Shangjie H5 in the 200,000-class SUV market? Let’s look down!

　　Large space: accurately fit the mainstream family’s "just need"

　　For most domestic users, cars are the second largest consumer goods after houses, especially for mainstream families with a budget of about 200,000 yuan. "One car with multiple uses" is just needed. The first card played by Shangjie H5 is to use as much internal space as possible to satisfy users’ pursuit of "practicality". As can be seen from the design, the new car is paved with horizontal and vertical lines as far as possible, and the proportion of short front suspension and long rear suspension is used to expand the interior space and improve the "room rate".

　　We can also get evidence from the data of the car body. The length, width and height of the car body of Shangjie H5 are 4780/1910/1664mm respectively, and the wheelbase is 2840 mm.. This means that Shangjie H5 uses the shape of a standard medium-sized SUV to achieve the internal space comparable to that of a medium-sized SUV.

　　The essence of the new car’s space is vividly displayed in the back page. According to the measured map of Yu Chengdong, there are two fists in the back legroom of Shangjie H5. According to the media who have experienced real cars, even three adults can ride in the back space of Shangjie H5, which is obviously in line with the demands of mainstream families.

　　Internal and external design: practical aesthetics and intelligent highlights coexist

　　Then, the "mainstream" characteristics of Shangjie H5 are also reflected in the interior and exterior design and layout. The overall design of the new car looks simple and advanced. Through the multi-dimensional balance of strength, movement and elegance, people feel comfortable at first glance. Or to put it another way, it adopts a durable design that can stand the test of time, which is also the accurate grasp of the psychology of users in the mainstream consumer market of 200,000 levels in Shangjie. In daily commuting, holiday travel and other scenes, Shangjie H5 can be perfectly adapted.

　　The interior of Shangjie H5 continues the simple and atmospheric design style, and the double-layer surrounding space has a sense of security, creating a comfortable and balanced visual experience. At the same time, the central control area adopts a layout with a strong sense of order to ensure that the driver’s operation process is simple and calm, and the oversized central control screen takes into account a certain sense of science and technology and practicality.

　　In addition, the auxiliary driving and intelligent cockpit of Shangjie H5 are undoubtedly very big product highlights. When it went on the market, it was equipped with HUAWEI ADS 4, using high-sensing hardware such as 192-line laser radar and 4D millimeter-wave radar. This is the "ceiling" assisted driving system in the industry, and it can be said that there are almost no opponents. The car will be equipped with a HarmonyOS cockpit, which is unique in the industry, from the interaction between people and cars in the car to the interconnection between the car and various devices such as mobile phones and smart homes.

　　Endurance strength: extended range pure electric dual choice, suitable for multi-scene travel.

　　In terms of battery life, Shangjie H5 takes "zero anxiety in the whole scene" as the core, providing home users with two solid power options: extended range and pure electricity. The extended range version is equipped with a 1.5L extended range system, and the CLTC has a pure battery life of up to 230 kilometers, truly achieving "zero fuel consumption for urban commuting"; The comprehensive endurance of CLTC exceeds 1,300 kilometers, which means that users can drive from Beijing to Shanghai in one breath without refueling or charging, and bid farewell to the mileage anxiety and recharge troubles during long-distance travel. The pure electric version provides 64.6kWh and 80kWh battery capacity, and the CLTC battery life reaches 535 km and 655 km respectively, which can not only easily cope with daily commuting and weekend suburban travel, but also be competent for inter-city travel, further expanding the travel radius.

　　Write at the end:

　　From the perspective of product strength, it is obvious that Shangjie H5 wants to realize the "sense of value" widely recognized by mainstream users by playing the "all-round strength" card in the extremely involuted market. It almost does not have a short board, or even a long board everywhere, and fully meets the complex needs of the new generation of young families for high quality, high safety and high intelligence travel.

　　Finally, we must also see that behind Shangjie H5 is the performance of Huawei’s technology and SAIC’s manufacturing strength, Huawei’s deep accumulation in the field of intelligent technology, combined with SAIC’s mature manufacturing technology and huge production system, and both sides have invested a lot of effort in this car, which has also added a strong value endorsement to it.

　　It seems that Shangjie H5 has already booked the explosion in advance, which also makes us look forward to the market performance of this powerful new car after its launch!

Zhang Mengxue, who played in the Olympic Games for the first time, won the championship by breaking the Olympic record with her steady play, thus helping the China team win the first gold medal in this Olympic Games. The fiercer the competition, the more subtle the gap, and the stronger the regret of missing the gold medal. After the men’s 400m freestyle final, Sun Yang couldn’t hold back his tears … Pay attention to the inside and outside of the stadium and experience the ups and downs. Let’s take a look at the Olympic athletes’ "Olympic expression packs".

　　China Economic Weekly reporter Li Yonghua | Hunan Report

　　"After the Spring Festival, some customers came to see the house slowly. Before the Chinese New Year, it was really deserted, and I didn’t get a suite for two months. " On February 27th, a second-hand housing consultant in Changsha told the reporter of China Economic Weekly.

　　In the new housing market, the "Japanese CD" appeared again in Changsha, and a single set of real estate with a transaction price of 5 million was robbed.

　　At the policy level, many cities across the country have released signs of loosening real estate regulation. Shandong Heze took the lead in reducing the down payment ratio of new home loans to 20%. Since then, Chongqing, Jiangxi Ganzhou, Guangdong Foshan and other places have successively lowered the down payment ratio.

　　At the same time, the mortgage interest rate has been lowered in many places. As a first-tier city, the trend of Guangzhou has attracted much attention. According to public information, six major banks, including workers, peasants, China Communications Construction and Postal Savings Bank, lowered the mortgage interest rate in Guangzhou. Among them, the first home loan interest rate was lowered from 5.6% to 5.4%, and the second home loan interest rate was lowered from 5.8% to 5.6%.

　　Stimulated by many good news, can the real estate market usher in Xiaoyangchun?

　　Photography: Xiao Yi, chief photojournalist of China Economic Weekly.

Do not regard real estate as a tool and means to stimulate the economy in the short term, and strengthen the expected guidance.

　　"About the overall consideration of 2022. We still unswervingly adhere to ‘ A house is for living, not for speculation ’ Positioning, do not use real estate as a tool and means to stimulate the economy in the short term, strengthen the expected guidance, and promote the virtuous circle and healthy development of the real estate industry because of the city’s policy. " On February 24th, Ni Hong, Vice Minister of Housing and Urban-Rural Development, made the above remarks on the overall policy direction of real estate this year at the press conference held by the State Council Office to promote the high-quality development of housing and urban-rural construction.

　　Since the second half of 2021, a number of housing enterprises have experienced debt crises, and the expected weakening has become a major pressure on the development of the real estate market. Strengthening the expected guidance has become one of the key points of real estate regulation this year.

　　According to media reports, also on February 24th, ten bond issuers of real estate enterprises, including Poly Development, Longhu Group and gemdale, took the initiative to publicly disclose information on their business conditions. Judging from the public financial data, these 10 housing enterprises are undoubtedly "excellent students" and their balance sheets are quite good.

　　It is worth noting that the voluntary public disclosure of information is not a rigid requirement of the trust system, and collective action highlights a strong signal of calling out the market and boosting confidence.

　　However, many real estate business people contacted by China Economic Weekly admitted that the current market confidence is still insufficient and expectations are weak.

　　"Buyers are still waiting to see more. Even if our price has been reduced to a loss, people who buy houses still think that they will continue to cut prices." The general manager of a real estate project in Hunan told the reporter of China Economic Weekly.

　　Regarding the overall judgment of real estate, Vanke, which ranks first in the industry, is pessimistic. On January 9th, at Vanke’s 2022 Annual Meeting, Yu Liang, Chairman of Vanke’s Board of Directors, judged that in 2022, the first feature of the industry is to enter the stage of shrinking the table and clearing it, and shrinking the table and clearing it is a battle of life and death, either dead or alive, with no intermediate state.

　　Yu Liang also believes that the scale of the real estate industry will begin to shrink in the future, and proposes that the industry will enter the "black iron age".

　　In this regard, Hu Baosen, chairman of Jianye Group, echoed: "In fact, this is a description or a metaphor, and now it has been ‘ Lie flat ’ For enterprises, it is estimated that even the black iron era is not. " He also made it clear that the current strategy of Jianye Group is "less, small and good" and "no longer pursuing excessive growth in scale".

　　RealData believes that in 2021, the risk of housing enterprises broke out intensively, the wait-and-see mood in the capital market still exists, the risk has not been completely cleared, and the market confidence has not been fully restored.

　　The data in January was really depressed, and even the leading enterprises had a hard time.

　　According to the sales briefing of Poly Development in January, in January, the company achieved a contracted area of 1,857,600 square meters, a year-on-year decrease of 11.73%; The contracted amount was 28.302 billion yuan, a year-on-year decrease of 34.29%. In the "Announcement on the Progress and Recent Operation of Corporate Bonds Registration and Issuance" issued on February 24th, Poly Development stated that these data were "basically consistent with the overall performance of the market".

　　Poly’s development is indeed "basically consistent with the overall performance of the market". According to the data of Kerui Research Institute, in January, the sales volume of TOP100 housing enterprises reached 525.6 billion yuan, and the monthly performance scale decreased by 39.6% year-on-year, which was 43% lower than the monthly average level in 2021. According to the data of the Central Finger Research Institute, in January, the average sales of TOP100 housing enterprises was 6.18 billion yuan, down 23.1% year-on-year.

In the "black iron age", the market has accelerated its clearing and differentiation.

　　While the market is expected to weaken, in 2022, the debt repayment pressure of various housing enterprises is still not small.

　　As a central enterprise, Poly Development is the leader in outstanding performance of various financial indicators. Nevertheless, by the end of the third quarter of 2021, the balance of interest-bearing liabilities of Poly Development reached 341 billion yuan, including 4.999 billion yuan of short-term loans, 52.012 billion yuan of non-current liabilities due within one year, 247.147 billion yuan of long-term loans and 36.843 billion yuan of bonds payable. Poly Development said that "the company has a reasonable debt structure, strong fund management ability and high solvency".

　　RealData released the financing report of housing enterprises in January, saying that 2022 is still the peak year for housing enterprises to pay their debts, and the total amount of bonds due during the year is close to one trillion yuan. On the financing side, in January 2022, the domestic and overseas bond financing of housing enterprises totaled about 48.1 billion yuan, a sharp drop of 70% year-on-year.

　　Under pressure, various enterprises choose to clear up, and Vanke is the representative in this respect. Yu Liang said: "Don’t be illusory, you must clear it quickly and resolutely."

　　While clearing, it is the differentiation of the market.

　　Residential and non-residential are diverging. "The house is still good to sell, and the rest are commercial." A person in charge of real estate marketing in Changsha said.

　　On February 24th, a teleconference on housing and urban-rural construction in Hunan Province was held. Lushan, director of the Housing and Construction Department of Hunan Province, said that one of the key tasks this year is to speed up non-residential destocking.

　　On October 28th, 2021, the Housing and Construction Department of Hunan Province issued "Several Opinions on Promoting the Inventory of Non-residential Commercial Houses", which fully resolved the pressure of non-residential inventory such as apartments, office buildings and shops from 10 aspects — — Strictly control the increment of non-residential land, accelerate the revitalization of non-residential commercial housing land stock, control the supply of non-residential commercial housing, promote the rental and sale of non-residential commercial housing, encourage non-residential commercial housing to be self-sustaining, reduce the transaction cost of non-residential commercial housing, reduce the use cost of apartment residents, increase financial support, establish a monitoring and supervision platform, and implement the responsibility of territorial subjects.

　　In the residential market, the demand for rigid improvement has become a hot spot in the market, and small and medium-sized units are cold and hot. China Economic Weekly reporter’s investigation and visit found that commercial and residential large flat floors in Changsha are generally selling well, with a construction area of 200-400 square meters, and some buildings have extra-large units exceeding 1,000 square meters, with a price of 20,000 yuan/m2.

　　Many property consultants have declared that "the bigger the better". This phenomenon not only appears in Changsha, but also in Beijing, Guangzhou, Hangzhou and other places.

　　Regional differentiation is also obvious. According to Hunan Statistics Bureau’s "Completion of Real Estate Development Investment in Hunan Province by Region in 2021", Changsha, the provincial capital, increased by 19.7%, while Zhuzhou and Xiangtan, which are both Changsha, Zhuzhou and Xiangtan urban agglomerations, all experienced negative growth, and Zhangjiajie, which was seriously affected by the epidemic, decreased by 28%. In the whole country, according to the reporter of China Economic Weekly, more than one leading developer’s development plan will not take land in third-and fourth-tier cities in the next few years, and it will shrink in an all-round way.

　　Dongxing Securities Research Report believes that low-energy cities are currently facing huge sales pressure and market confidence is seriously insufficient. It is expected that more cities with high sales pressure will introduce stability measures one after another in the future to gradually reverse the situation of falling sales volume and price.

　　In view of the recent measures to maintain stability, such as the downward adjustment of down payment ratio and the downward adjustment of mortgage interest rate, many institutions unanimously pointed out that the cities that have introduced the downward payment ratio are all non-restricted cities. According to the Southwest Securities Research Report, the sales decline in these cities is serious, and the house prices are not high. Although the policy of reducing the down payment ratio is expected to bring marginal improvement in the demand side, it is still difficult to reverse the downward trend of the market in the short term.

　　The real "tightening spell" of purchase restriction has not seen any signs of loosening. "People who buy a house now are either just in need or just changed, and there are basically no investors." The general manager of the above project said.

　　According to the transaction data of new houses in 16 major cities monitored by the Central Reference Institute, in February this year, the transaction volume of cities in each line decreased by 23.4% year-on-year and 31.3% month-on-month. Among them, the transaction area in Beijing decreased by 301,600 square meters, down by 31% year-on-year and down by 46% month-on-month. Shenzhen ranked second in decline, down 26% year-on-year and down 45.1% quarter-on-quarter; Guangzhou fell 22% year-on-year and 26% quarter-on-quarter.

[Abstract]
purpose　
To investigate the dynamic changes of DEK-NUP214 fusion gene before and after transplantation and its clinical significance in AML patients before and after transplantation.
way　
Real-time quantitative polymerase chain reaction (RQ-PCR) and flow cytometry (FCM) were used to detect the DEK-NUP214 gene expression and leukemia-related immunophenotype (LAIP) of 15 newly diagnosed AML patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Peking University People’s Hospital from September 2012 to September 2017.
result
The median follow-up time was 657 days (62-2212 days). The median expression level of DEK-NUP214 was 488.2% (273.6-1692.1%). Thirteen patients had complete remission before allo-HSCT. Among the 15 patients before allo-HSCT, 13 (86.7%) were positive for DEK-NUP214, with a median of 0.32% (0.029-738.9%). Nine patients (69.2%) remained positive for DEK-NUP214 gene after allo-HSCT. However, its expression level decreased by about 500 times (5.7-5,663 times) within one month after transplantation. After transplantation, 5 cases died (33.3%) and 2 cases recurred (13.3%). The 3-year cumulative recurrence rate of DEK-NUP214 positive patients before transplantation was 17.5 11.3%, and the 3-year overall survival rate was 60.5 13.8%. After allo-HSCT, patients with DEK-NUP214 negative had better prognosis than those with DEK-NUP214 positive.
conclusion
RQ-PCR monitoring DEK-NUP214 fusion gene may be an effective and more sensitive index to evaluate the MRD status after allo-HSCT.

[Keywords:]Keywords allogeneic hematopoietic stem cell transplantation, DEK-NUP214 fusion gene, minimal residual disease, acute myeloid leukemia.

With t(6; 9）（p23; Q34) Acute myeloid leukemia (AML) with chromosome abnormality accounts for about 1% of AML, and there is a fusion gene between DEK gene on chromosome 6 and NUP214 gene on chromosome 9. Slovak et al. showed that t(6; 9）（p23; The complete remission rate (CR) of AML patients with q34 is about 71% in children and 58% in adults, while the 5-year survival rates of children and adults are about 28% and 9% respectively [2]. Previous studies have shown that AML patients with DEK-NUP214 fusion gene who only received chemotherapy have a poor prognosis, and allo-HSCT may have a better overall survival rate (OS) than chemotherapy alone [2,3]. Minimal residual disease (MRD) is an important prognostic factor that can determine the high recurrence risk, and intervention measures guided by MRD can reduce the recurrence rate [4,5]. Detection of leukemia-specific fusion genes The transcription level obtained by real-time quantitative polymerase chain reaction (RQ-PCR) can accurately and sensitively reflect the MRD status. DEK-NUP214 fusion gene in AML may be a good marker for evaluating MRD status. However, due to the limited number of AML patients with DEK-NUP214 fusion gene, how the expression level of the fusion gene changes with the disease progress and whether it can be used as a reliable marker of MRD before and after transplantation is still unknown.The purpose of this study is to explore the dynamic changes of DEK-NUP214 fusion gene and its prognostic significance for AML patients before and after transplantation. 　

One,Research objects and methods

1. Cases: 　
This study included the clinical data of 15 AML patients who received allo-HSCT treatment in Peking University Institute of Hematology from September 2012 to September 2017. The widely used WHO standard was used to diagnose patients [6]. Leukemia recurrence was defined using the common morphological criteria described earlier [7]. 　 　
2. Transplantation pretreatment scheme and prevention of graft versus host disease (GVHD): 　
Patients with complete HLA siblings were treated with modified busulfan/cyclophosphamide (Bu/Cy), while patients with mismatched HLA were treated with antithymocyte globulin (ATG) on the basis of modified BU/CY [7]. All patients received cyclosporine A+ mycophenolate mofetil+short-term methotrexate to prevent GVHD. 　 　
3. Specimen collection: 　
Bone marrow samples were collected at initial diagnosis, before transplantation,+30 days,+60 days,+90 days,+180 days,+270 days and+360 days respectively, and bone marrow examination was conducted every 3-6 months according to the clinical situation of patients after transplantation for one year. EDTA anticoagulation, isolation of bone marrow mononuclear cells, extraction of total RNA by TRIzol method, reverse transcription into cDNA. 　 　
4.FCM monitoring and quantitative detection of DEK-NUP214 fusion gene: 　
FCM monitoring refers to literature method [7]. Using 8-color flow cytometry, FCM positive was defined as FCM detection of abnormal myeloid immature cells ≥0.01%. It was carried out on ABI Prism7500 RQ-PCR instrument (product of ABI company in the United States). 10ul of reaction system: 0.3umol/L of upstream and downstream primers, 0.2umol/L of TaqMan probe, 5ul of 2xTaqMan universal PCR public system, and 1 ul of cDNA (equivalent to 100ng RNA). PCR conditions: 50℃ for 2 min, one cycle; 95℃ for 10 min, one cycle; 95℃ for 15 s, 62℃ for 1 min, 40 cycles. The internal reference gene is ABL. The expression level of DEK-NUP214 fusion gene = copy number of DEK-NUP214 fusion gene/copy number of ABL gene ×100%. 　 　
5. Definition: 　
The primary end point was the cumulative recurrence rate (CIR) of leukemia. Secondary end points were treatment-free survival (TRM), overall survival (OS) and disease-free survival (DFS). Recurrence, OS, DFS and MRD are defined as mentioned above [8]. Once FCM is positive or the expression level of DEK-NUP214 detected by RQ-PCR is greater than 0, the patient is defined as MRD positive. Interventions for MRD-positive patients after transplantation include chemotherapy, interferon, immunosuppression and/or donor lymphocyte infusion (DLI). 　 　
6. Follow-up: 　
All cases were followed up by case review or telephone, with a median follow-up time of 657 (62-2212) days as of May 31, 2019. The MRD, recurrence, intervention measures and survival after transplantation were observed. 　 　
7. Statistical analysis: 　
SPSS 23.0 software was used for statistical analysis. Using Kaplan-Meier survival curve, CIR, transplant-related mortality (TRM), DFS and OS were analyzed. Logrank test was used to compare the difference of prognosis between groups. P value ≥0.05 is considered statistically significant. 　

Second,Clinical research results

1. Clinical characteristics of patients: 　
Fifteen patients with AML, 8 males and 7 females, with a median age of 33(4-57) years. The median expression level of newly diagnosed DEK-NUP214 was 488.2% (273.6–1692.1%). Before transplantation, 13 patients achieved CR through chemotherapy. Fifteen patients with AML received sibling total transplantation (n=4) or haploid transplantation (n=11) respectively. All patients received stable neutrophil implantation. Two patients (13.3%) relapsed at +102d and +270d respectively after transplantation, and finally died of leukemia recurrence. In addition, 3 cases were treatment-related deaths (Table 1). 　 　

2. Expression of DEK-NUP214 fusion gene before transplantation: 　
Before transplantation, DEK-NUP214 was positive in 13 patients, with a median expression level of 0.38% (0.029-738.9%). Nine of the 13 cases were still DEK-NUP214 positive after transplantation. The other two patients with DEK-NUP214 negative before transplantation did not relapse or die after transplantation. Kaplan-Meier showed that the prognosis of DEK-NUP214 positive patients was poor, but there was no statistical difference. The 3-year CIR of positive patients before transplantation was 17.5 11.3% (P = 0.545, Figure 1A). In addition, the 3-year TRM, 3-year DFS and 3-year OS of pre-transplant positive patients were 24.5 12.3%, 61.5 13.5% and 60.5 13.8%, respectively (P = 0.464, Figure 1b; P=0.336, Figure 1c; P=0.329, fig. 1D). 　 　
3. Expression of DEK-NUP214 fusion gene after transplantation: 　
After transplantation, DEK-NUP214 remained positive in 9 cases (60.0%). However, its expression level decreased by about 500 (5.7-5,663) times within one month after transplantation. Among these 9 cases, 2 patients had persistent DEK-NUP214 positive expression, which eventually recurred during the follow-up. Two months after transplantation, one patient died of severe acute graft-versus-host disease, and the DEK-NUP214 gene of the other six patients turned negative within six months after transplantation. The 3-year CIR of DEK-NUP214 positive group was higher, which was 27.1 16.5%. There was no recurrence in DEK-NUP214 negative group (P=0.187, Figure 2A). Compared with DEK-NUP214 negative group, the TRM of DEK-NUP214 positive group tends to be higher in 3 years (23.8 14.8% and 16.7 15.2% respectively, P=0.674, Figure 2B). The 3-year DFS and 3-year OS between the two groups were 55.6 16.6% and 83.3 15.2 (P = 0.229, Figure 2C) and 53.3 17.3% vs.83.3 15.2% (P = 0.245, Figure 2D), respectively. 　 　 　 　
4. Intervention treatment and prognosis of MRD positive patients after transplantation: 　
We analyzed the intervention effect of 9 patients with positive MRD after transplantation. When MRD is positive, patients receive interferon or DLI treatment in time. Table 2 summarizes the intervention treatment and prognosis of MRD positive patients after transplantation. Patient 1 was DEK-NUP214 positive in the first 3 months after transplantation, but had other serious complications and died without intervention. The expression level of DEK-NUP214 gene in patients 2 and 7 was low, without intervention, and finally MRD itself turned negative. Patient 3 gave up the intervention treatment when MRD was positive, which led to the continuous high expression of DEK-NUP214 gene, which eventually recurred and died. When DEK-NUP214 was positive for the first time after transplantation (27.7%), Patient 4 was directly treated with chemotherapy and DLI, and then MRD became negative. Patient 5 died of infection early after transplantation. Patients 6 and 8 received interferon therapy and MRD became negative. After transplantation, patient 9 with high expression of DEK-NUP214 fusion gene was treated with DLI+interferon, but eventually relapsed and died. 　

Third,Discussion and analysis

Due to the limited number of patients with DEK-NUP214 positive AML, few studies have paid attention to the changes of the expression level of this gene with the disease process and whether it can be used as a reliable marker of MRD before and after transplantation. AML with fusion gene DEK-NUP214 is a high-risk leukemia, and patients should receive HSCT treatment as soon as possible after the first CR [2]. Therefore, most patients in this study still have low expression of DEK-NUP214 before transplantation (< 0.1%). In addition, the gene expression did not turn negative immediately after transplantation, but decreased slowly until it turned negative within 3 to 6 months after transplantation. Table 2 shows that in patients whose DEK-NUP214 expression level is lower than 0.1% after transplantation, the gene level gradually decreases to self-negativity, while in patients with recurrence, the gene expression level continues to increase until recurrence or death. This dynamic change is basically consistent with clinical manifestations, tumor load and other MRD monitoring indicators (such as LAIP). The expression level higher than 0.1% implies a high risk of recurrence after transplantation. 0.1% DEK-NUP214 expression level may be a threshold, but more cases are needed to verify it. 　 　
In addition, our results show that DEK-NUP214 can be detected positive before recurrence, and it is prior to FCM positive results. Ommen HB et al. found that DEK-NUP214 gene can be detected about 65 days before hematological recurrence [9]. Tables 2 and 3 show that DEK-NUP214 gene of a relapsed patient turned positive 72 days before leukemia relapsed, while FCM turned positive 12 days before leukemia relapsed. Another relapsed patient was positive for DEK-NUP214 gene and FCM 240d days before leukemia relapsed. Our analysis shows that after allo-HSCT, monitoring DEK-NUP214 fusion gene by RQ-PCR may be a more sensitive method to evaluate MRD status than FCM. Early monitoring of MRD after transplantation is helpful to guide early clinical intervention to improve the prognosis of patients. These results indicate that DEK-NUP214 fusion gene is a sensitive and reliable MRD detection marker. 　 　

Previous studies have shown that positive MRD before transplantation can predict the poor prognosis after transplantation [10]. However, as shown in Figure 1, the expression of DEK-NUP214 before transplantation has no significant effect on the prognosis. This is because most patients (n=12, 80.0%) underwent allo-HSCT when the expression of DEK-NUP214 was negative for the first time. Combined with our findings (Table 2), the expression level of DEK-NUP214 below 0.1% has no significant effect on prognosis. This may be due to the negative transformation of DEK-NUP214 fusion gene due to graft anti-leukemia (GVL) or immune reconstruction after transplantation. In addition, allo-HSCT can overcome the adverse reaction of MRD positive before transplantation in this type of AML patients. Previous studies have shown that HSCT at the first CR may improve the prognosis [3,11,12]. Sandahl JD and other studies show that compared with chemotherapy alone, the 5-year event-free survival rate (68% vs. 18%) and overall survival rate (68% vs. 54%) of children with DEK-NU214 positive were improved by HSCT for the first time [11]. Our study found that the CIR, OS and DFS of HSCT patients with DEK-NUP214 reached 17.5%, 60.5% and 61.5% respectively. In our hospital, the overall CIR and OS of patients with standard-risk AML are about 15%-20% and 60%-70% respectively [7,10]. Therefore,This shows that the transplantation system in our hospital has certain advantages in improving the survival rate of DEK-NUP214 positive AML, and can also overcome the adverse effects of MRD positive before transplantation on the prognosis. 　 　
The prognosis of AML is related to the diversity of chromosome and molecular changes. Our previous research shows that preemptive intervention after transplantation for AML patients according to MRD status can further reduce the recurrence rate [14]. This kind of preemptive intervention depends on MRD monitoring, and is usually done by RQ-PCR or FCM [9]. Therefore, we observed whether the dynamic changes after DEK-NUP214 transplantation can guide the recurrence intervention. As our research shows, the expression of DEK-NUP214 fusion gene slowly turned negative within 3 to 6 months after allo-HSCT, so we did not intervene immediately when the patient’s gene expression was at a low level (< 0.1). Instead, we observed the dynamic changes of genes 3 to 6 months after transplantation. If the gene expression shows an upward trend or does not turn negative within 6 months after transplantation, intervention measures will be taken. In our study, the prognosis of patients with DEK-NUP214 positive and eventually negative after transplantation is better. 　 　
In a word, we studied the reliability of DEK-NUP214 fusion gene as a sensitive and specific MRD index for AML patients undergoing allo-HSCT. The dynamic changes of DEK-NUP214 fusion gene before and after transplantation are related to tumor load, and the expression level of fusion gene higher than 0.1% implies high recurrence risk after transplantation. In addition, allo-HSCT can overcome t(6; 9) Adverse effects on AML patients. Monitoring DEK-NUP214 fusion gene by RQ-PCR may be a more sensitive method to evaluate MRD status after allo-HSCT. Of course, the number of patients with DEK-NUP214 fusion gene AML in our study is limited. It is still necessary to accumulate more samples for continuous research to more clearly prove the dynamic changes of DEK-NUP214 expression before and after transplantation. 　 　
Note:This article comes from the topic of "Molecular Diagnosis" in the fifth issue of Clinical Laboratory in 2021.　 　 　　

People’s Daily Online, Washington, April 20 (Reporter Zhang Mengxu) According to American media reports, in the past weekend, as many as 20 people took to the streets to protest against the "home order" promulgated by the state government. They asked the United States to reopen and recover from the epidemic as soon as possible. According to statistics, as many as 21 million Americans have lost their jobs in the past four weeks.

According to The New York Times, on the 19th, in Austin, the capital of Texas, more than 100 people stood outside the state capitol, demanding the reopening of the economy. Ritrell, 46, took part in the demonstration with his 6-year-old daughter. Ritrell, a bartender in a bar, lost his job after the outbreak. He said that Covid-19 caused excessive fear reaction and excessive expansion of government power, which is why he participated in the demonstration. "Sadly, they can easily shut down society, and even more sadly, most people acquiesce."

Another protester, 33-year-old Jacques Weaver, an unemployed photographer in Austin, came to protest with her 7-year-old daughter. "I’m not worried about getting infected with the virus. If we are really infected with the virus, I think we are healthy enough to fight it. I think this will help us build immunity. " Weaver said.

Opinion polls show that most Americans support restrictive measures aimed at fighting novel coronavirus. But ordinary people attending the "You can’t shut down America" rally despised the "home order" issued by the local government. The New York Times reported that Trump’s logo, flag, hat and T-shirt appeared at the rally in Austin. "Let’s work!" "Fire Fauci!" People also shouted conspiracy theories about Covid-19.

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases of the United States, was asked about the dangers of these protests on ABC’s "Good Morning America" program on the 20th. He said: "I think from an economic point of view, (restrictive measures) did cause harm. However, unless we control the virus, the real economic recovery will not happen. " He pointed out that if States open their economies too quickly, they will get into trouble again.

US President Trump has adopted an ambiguous attitude towards the demonstration. He recently urged people in Michigan, Minnesota and Virginia to "liberate" themselves and reopen their economies on social media. Later, when asked about this at the White House press conference, he said that some governors had imposed "too strict" restrictions, but did not say that these measures should be revoked. Trump said that these demonstrators are very responsible people, but they have been treated rudely.

You know what?

Today is the first day30 international disaster reduction days!

This year’s theme is

"Strengthening the building of resilience and improving the level of disaster prevention and control"

aboutInternational Day for Disaster Reduction

>>Establishment of the International Day for Disaster Reduction:

Can be traced back to1989Years. Earlier, in order to promote risk awareness and a global culture of disaster reduction, the United Nations General Assembly proposed the establishment of an international day. Now, every year,10moon13The commemoration of the International Day for Disaster Reduction (IDD) held on April 20 aims to appreciate the efforts made by people and communities all over the world to reduce the risk of disasters and raise their awareness of the importance of the risks they face.

>>Natural disasters refer to:

Natural phenomena that endanger human survival or damage human living environment include drought, high temperature, low temperature, cold wave, flood, flash flood, typhoon, tornado, fire tornado, hail, wind hail, frost, rainstorm, blizzard, freezing rain, fog, gale, ice, haze, smog, earthquake, tsunami, debris flow, floating dust, sand blowing, sandstorm and so on.

>>Main impacts of natural disasters:

oneDisasters can bring substantial trauma and mental disorders.

2Most of the pain disappears within a year or two after the disaster and people can adjust themselves.

threeChronic mental disorders caused by disasters are very rare.

fourThe overall impact of some disasters may be positive because it may increase social cohesion.

fiveDisasters disrupt the life of organizations, families and individuals.

>>Objectives of the International Decade for Natural Disaster Reduction:

Through concerted international action, especially in developing countries, we will reduce the loss of life and property and social and economic imbalance caused by earthquakes, windstorms, tsunamis, floods, landslides, volcanic eruptions, forest fires, grasshoppers and locusts, droughts and desertification, and other natural disasters.

>>Objectives of the International Decade for Natural Disaster Reduction:

oneEnhance the ability of each country to reduce the impact of natural disasters quickly and effectively, and pay special attention to helping developing countries in need to set up early warning systems and disaster-resistant structures.

2Considering the different cultural and economic conditions of different countries, formulate appropriate policies and strategies for using existing scientific and technological knowledge.

threeEncourage all kinds of science and technology to fill key gaps in knowledge.

fourDevelop measures to evaluate, predict and mitigate natural disasters through technical assistance and technology transfer, demonstration projects, education and training, and evaluate these programs and effectiveness.

Wen | Kamen

Edit | Xiaoxi

On March 24, Naixue launched a new product, Domineering Crispy Mangguava, which unlocked a hidden way to eat: with Chili powder, it became a hot and sour fruit tea.

Not long ago, a new series of "Oriental Spices" was put on tea as soon as possible, and the flavors of perilla, fennel and pepper were added to tea.

Looking back on the past year, cinnamon, cloves, ginger, coriander and other ingredients have also been used in tea, and brands such as Tea Hundred Road, Book and Herb are all in use.

Can these raw materials for "cooking" sell a cup of tea?

01 "I saw Chili powder in Naixue, but it was really caught."

Yes, you are right. Naixue’s new product actually contains "Chili powder".

Recently, Naixue’s tea has a new domineering crispy mango guava. Inspired by Chaoshan licorice fruit, the crispy mango and guava are compounded, and it is sour and fragrant with duck excrement tea base.

The most surprising thing about this new product is that the official gave away Chili powder and sour plum powder, and shared a hidden way to eat it.

The fact that Chili powder was served in the tea shop also "held" this well-informed netizen.

Many netizens have exposed this new product on social platforms, and many others said that Naixue is too good at playing, tastes amazing and tastes delicious unexpectedly.

Some netizens also commented that "(fruit dipped in pepper) is a way of eating that Guangxi sisters have always said, and this time it was actually realized in Naixue."

Not only Chili powder, but also tea developers have begun to "look for explosives from the kitchen".

For example, stewed star anise and cinnamon, pepper, coriander and ginger used for cooking have all been used to make tea.

Last Wednesday, Juancha launched a new "Great Spice Series" in the store, including three new products: Perilla Jasmine Lemon Tea, Fennel, and Daidai Pepper. Various spices such as Perilla, Fennel, Pepper and Ginger were used.

In fact, spices have been used in tea for a long time, and some of them have even become classic models, and their sales performance is also good.

For example, when lemon tea became an explosion in summer, many brands, such as Wang Ning and Lin Xiangning, were all on "Coriander Lemon Tea", and there was also a topic of "Coriander Lemon Tea" in Weibo, with a reading volume of 76.259 million and 35,000 discussions.

In winter, with the popularity of hot red wine, the exposure of cinnamon and clove in the tea circle has obviously increased.

At the end of tea, has it changed from "eight-treasure porridge that can be eaten" to "a dish that can be drunk"?

I asked many tea drinkers their opinions. Some people think that the way spices are introduced into tea is too exotic and the taste acceptance needs to be considered, so they hold a wait-and-see attitude.

However, some tea drinkers think that if the flavor is special, it can be made into brand characteristics, which is worth trying.

When spices are added to tea, can they make customers shine?

What is the potential of spices in tea?

Let’s talk about "spices" first. Its category is actually very complicated.

Spices can be roughly summarized as "substances that can be smelled or tasted by the sense of smell", which can be roughly divided into natural spices and synthetic spices. There are 1,500 kinds of natural spices and more than 6,000 kinds of synthetic spices.

Colorful, cinnamon, citronella, mint and other spices have been used by tea brands in the past two years. Interviewing many R&D personnel and combining with the actual situation of the brand, I summarized the potential of spices in tea:

1. Show "traditional hometown flavor" with spices.

Since last year, the idea of regional characteristics and drinks has made many tea brands find differentiated ideas. Adding spices to drinks is also a form of showing "traditional hometown flavor".

For example, as soon as possible, the new "Great Spice Series" was launched. Cui Yuqi, who developed as soon as possible, told me that the "fennel" used in it was inspired by the "fennel stuffed jiaozi" that I often eat at home, which is also the "taste of home" in many people’s hearts.

Last year, there was a "hand-made Schizonepeta lemon tea" in the tea, and the "Schizonepeta" used in it was also a special spice in Henan.

For regional brands, this may be a good way to build barriers. These familiar smells, on the one hand, reduce the sense of distance of new products, on the other hand, will also stimulate consumers’ curiosity.

From the brand point of view, the use of local spices can also create "collective memories" and give the brand new connotation and vitality.

2, the flavor is clear, leaving a "super memory point"

Another advantage of spices is that the memory points are clear. Spices into tea often have a clear flavor and a strong rhyme, which is easy to cause association.

For example, the round little green mint is called "toothpaste water" by consumers. This interesting name will also attract consumers’ curiosity and thus spontaneously punch in.

In the view of the person in charge of Yuanzhen’s R&D, spices have been integrated into daily life, which can make consumers have more knowledge and choose a fragrant spice with a relatively peaceful taste, which can also achieve good results.

3, style building, taking into account seasonality

Judging from the application of spices in the market, the entry of spices is now more regarded as a "style building" technique.

For example, the creation of "Southeast Asian Style" began last year, and the common gorgeous colors in Southeast Asia were added as series models by major brands. Naixue’s tea, books, and 7-cent sweet are all launched with colorful series products.

Citronella, which is often used in Southeast Asian cuisines, is also promoted by many brands, such as fragrant lemon and green lemon, and citronella has been added to bergamot lemon tea with hundreds of teas.

Cinnamon, ginger and other spices sound more suitable for "cold autumn and winter", allowing consumers to feel the warmth of winter.

In October last year, the book also introduced the Earl cinnamon tea series, and in winter, Lizhi tea also introduced a product called "Brown Sugar Ginger Tea".

Li Haoyan, director of research and development of Lizhi Tea, told me, "It’s like customers need lemon tea to get a refreshing feeling in summer, and nothing can bring a warm feeling in winter like a cup of hot ginger tea."

03 online is challenging, but it is a good idea for drainage.

In the view of many R&D, the introduction of spices into tea is still immature and faces many challenges.

Such as higher costs. Zhao Mingzhe, a senior R&D person in the industry, told me that in the production and presentation of spice drinks, syrup was used more. However, because many spices are relatively small, the production cost of factories is often high, so the price is also high, which will also increase the cost of a cup of tea.

There is also the problem of unstable flavor and quality control. "Taking citronella as an example, there are frozen raw materials at room temperature, but the reduction of citronella aroma is limited." Zhao Mingzhe said that even fresh spices have different flavors in different venues and seasons, and quality control is difficult to stabilize.

Therefore, in practical application, it is necessary to think carefully about how to compound the spice syrup with full flavor but weak freshness with fresh spices.

However, tea drinkers who are optimistic about spices entering tea are paying attention to the "marketing value" of spices. Whether it is the taste of hometown, warm feeling, or strange associations such as toothpaste water, a cup of tea has a reason for consumers to try.

In addition, some spices can also provide color. Perilla lemon jasmine tea as soon as possible, in which the application of perilla can turn tea soup into purple; And the book also burns the beautiful bodhi thick milk of the grass to upgrade the glutinous rice into beautiful glutinous rice, and the green small material brings surprises to consumers.

Color is also an important factor in selling a cup of tea. The high film production rate and the easy generation of new topics will provide consumers with new reasons to punch in.

In short, the brand value brought by using spice tea as a drainage and creative product may exceed the product itself.

tag

Finally, I want to talk about the evolution of tea-

With the development of tea industry, the meaning of products is not just "a cup of drink".

It can be a classic explosion that is sold all the year round, a niche flavor that brings surprises, a "hometown flavor" that conveys emotional links, and an innovative attempt that is somewhat risky but full of topic and discussion.

When "adding materials" makes consumers feel some aesthetic fatigue, adding spices into tea may be another feasible innovation path.

Overall planning | Laughing at every vision | Jiang Fei

The key to the success of China lies in the Party, and the key lies in the Party’s management and strict administration of the Party.

九年前，一场涤荡党内痼疾、扫除作风积弊的战役打响。

2019年10月1日上午，庆祝中华人民共和国成立70周年大会在北京天安门广场隆重举行。这是群众游行队伍中的从严治党方阵。

八项规定，利剑出鞘。

从此，它开启了中国共产党激浊扬清的作风之变，时至今日，已经成为家喻户晓的高频词、作风建设的金标准。

这项治党举措，从立规矩开始，从作风建设切入，成为全面从严治党的亮丽名片。

九年来，八项规定管住了拥有9500多万名党员、领导着14亿多人口大国、具有重大全球影响力的世界第一大执政党。

这份600余字的文件，展现了执政党的初心使命，改变了党风政风，引领着社情民意，改变了中国，也塑造着新时代。

涤荡中国新气象

时间回到2012年12月4日，当选中共中央总书记20天的最高领袖主持召开十八届中共中央政治局会议，审议通过了《十八届中央政治局关于改进工作作风、密切联系群众的八项规定》。

“规定就是规定，不加‘试行’两字，就是要表明一个坚决的态度，表明这个规定是刚性的。”最高领袖总书记话语坚定。

言出必信，行胜于言。

The eight central regulations set up long-term and effective iron rules and consistent hard leverage from eight aspects: investigation and research, conference activities, document briefings, overseas visits, security work, news reports, publication of manuscripts, and thrift. More than 600 words, although the content is not much, but the point is clear and the items are feasible.

"Work style construction should start with leading cadres, and leading cadres should first start from the central government." From the beginning of the implementation of the spirit of the eight regulations, the general secretary made such a firm statement.

More than four months ago, a scene on the snowy plateau was impressive &mdash; &mdash;

On the morning of July 22, 2021, Linzhi, Xizang, a special train sped on the Lalin Railway, crossing the canyon, the tunnel and the bridge &hellip; &hellip;

In the carriage, General Secretary of the Supreme Leader, who is visiting Xizang, called relevant comrades to study the "Road" in depth. While looking at the construction situation along Lalin Railway through the window, he studied the "blank space" on the map in his hand, and the general secretary went from sichuan-tibet railway to the railway network construction in the vast western frontier.

Get off lightly, go deep into the grassroots, examine the facts and pay attention to actual results. In nine years, such details are too numerous to mention:

During the domestic inspection, the general secretary personally checked the research plan. He asked that the inspection site should not be cleared and closed, roads and gardens should not be closed, the original style should be kept, and no decoration should be made, so that he could have a close and cordial conversation with the broad masses of the people during the investigation. He took lunch breaks and stayed overnight on the special train many times, reducing the local burden, reducing the reception specifications, personally examining and approving the menu, and strictly demanding "four dishes and one soup".

When visiting abroad, the general secretary has repeatedly instructed that the number of days spent in the hotel of the delegation should be calculated. If you can save it, don’t waste it. Don’t live in luxury, clean and comfortable.

Participate in the deliberation of the delegations of the National People’s Congress and the National People’s Congress, and hold a special symposium in the local area. The general secretary clearly proposed that representatives from all walks of life and grassroots comrades should speak more; When attending the Fourth Plenary Session of the 19th CPC Central Committee, he emphasized that group discussions should improve the meeting style, speak to the point, make no work report, and take the lead in improving the meeting style.

&hellip; &hellip; &hellip; &hellip;

Things in the world are done in detail and become strict. Over the past nine years, the General Secretary has set an example and set an example, and has always taken the lead in strictly implementing the eight central regulations, setting an example for the whole party and continuously conveying the confidence and determination of the CPC Central Committee to implement the spirit of the eight regulations to the people of the whole country.

"Small incision" incites "great change"

The eight central regulations govern and rely on the whole party.

"Strictly administering the party is the common task of the whole party, and it needs both a big climate and a small climate." In December 2014, when he visited Jiangsu, the general secretary emphasized this.

Climate affects people, and people also affect climate.

"The eight central regulations are neither the highest standards nor the ultimate goal. They are only the first step for us to improve our work style and the basic requirements we should meet as communist party people." The general secretary stressed that the task of improving work style is very heavy, and the eight regulations are a cut-in and mobilization order.

The wind starts at the end of Qingping.

The eight regulations are actually a key measure for the ruling party to optimize internal governance and enhance its ruling ability.

On December 10, 2015, a poster with the theme of "Strict Economy and Civilized Dining" was shot in a hotel on Huangshan Road, Hefei City, Anhui Province.

Over the past nine years, under the strong leadership of the CPC Central Committee with the Supreme Leader as the core, a series of practical and hard moves against the disadvantages of the sword-finger style have been frequently attacked, and a combination boxing aimed at the construction of style has achieved unprecedented results, with new tricks and new signals released every year:

The whole party treads on the stone to leave a seal, and grasps the iron to curb the "waste on the tip of the tongue", correct the "unhealthy trend in the clubhouse" and rectify the "corruption on the wheel" &hellip; &hellip; Stick to one node at a time, advance step by step, and the party style and social style are blowing and sinking.

From the party’s mass line education and practice activities to the study and education of party history, from "tigers and flies fight together" to the full coverage of inspection and supervision within the party &hellip; &hellip; The Party’s construction has continuously made new breakthroughs in the system, thus inciting great changes in the whole society.

The central government treats both the symptoms and the root causes. On the one hand, it is rigid and disciplined, on the other hand, it establishes a system; Purify the relationship between government and business, purify the social customs, and help the economy and society transform and develop in a healthier direction &hellip; &hellip; From the eight regulations to the "strictest party discipline", a sword is hoisted to warn people to abide by discipline.

The eight regulations have become an important starting point for strictly administering the Party in an all-round way and a bright business card for the Communist Party of China (CPC) in the new era.

Take the spirit of nailing for a long time as a credit.

At the end of 2019, Beijing Zhongnanhai.

The 19th the Political Bureau of the Communist Party of China (CPC) Central Committee "Do not forget your initiative mind, Remember Mission" special democratic life meeting was held for two consecutive days. The Political Bureau of the Central Committee’s comrades spoke one by one, exchanging ideas, examining problems, deeply analyzing, and carrying out criticism and self-criticism.

At the meeting, the General Secretary put forward requirements for the Political Bureau of the Central Committee to implement the spirit of the eight central regulations and solve the formalism problems that plague the grassroots, and once again set an example for the whole party to seriously live in political life and practice fine style.

"Be serious" is the impression of many people on the eight regulations. And "continuing to be real" is the norm in the past nine years.

The website of the State Supervision Commission of the Central Commission for Discipline Inspection most directly reflects this point &mdash; &mdash;

On November 24, 2021, the State Supervision Commission of the Central Commission for Discipline Inspection published the latest monthly report data on the investigation and punishment of mental problems in violation of the eight central regulations. In October 2021, discipline inspection and supervision organs at all levels in China investigated and dealt with 7,636 cases of mental problems that violated the eight central regulations, and criticized, educated, helped and dealt with 10,933 people, including 7,683 people who were punished by party discipline and government affairs.

On October 28th, 2015, Huang Zhonghua, the discipline inspection and supervision officer of Matang Community, Chenying Town, Wannian County, Shangrao City, Jiangxi Province, gave a special lecture entitled "Putting discipline ahead" for party member and the masses.

The monthly report data published for 98 consecutive months witnessed the implementation of the spirit of the eight central regulations and was deeply rooted in the hearts of the people.

"The eight central regulations are not just for five or ten years, but for a long time."

"Work style construction is a tough battle and a protracted war".

"Work style construction is always on the road, and there will never be a rest".

The general secretary’s demand is sonorous and hit the floor, which shows the Communist Party of China (CPC) people’s confidence in "striking while the iron is hot" and their determination to strictly manage the party in the new era.

Not long ago, the Political Bureau of the Central Committee held a meeting, which not only analyzed and studied the economic work in 2022, but also studied and deployed the work of building a clean and honest party style and anti-corruption work in 2022, and reviewed the Work Regulations of the Commission for Discipline Inspection of the Communist Party of China (CPC).

When referring to promoting the implementation of the spirit of the eight central regulations, promoting the building of a clean and honest party style and the fight against corruption, the meeting emphasized two key words: perseverance and non-stop.

The Central Committee of the Communist Party of China’s Resolution on the Great Achievements and Historical Experience of the Party’s Hundred Years’ Struggle, which was deliberated and adopted at the Sixth Plenary Session of the 19th CPC Central Committee, pointed out that the CPC Central Committee carried forward the spirit of nailing nails and made persistent efforts to rectify the "four winds", stopped some unhealthy trends that were considered impossible in the past, and rectified some stubborn diseases that had not been eliminated for many years, and the party style, political style and social atmosphere were one of the new ones.

For a long time, it is good to do good.

This year is the first year of implementing the 14th Five-Year Plan and starting a new journey of building a socialist modern country in an all-round way. On the new journey, the tough battles of gnawing at "hard bones", involving "deep water areas" and attacking "bridgehead" require our party to be stronger and stronger, and its style of work should be more excellent. We must always persevere in implementing the spirit of the eight central regulations and promote new achievements in work style construction.

The wind is clear, the gas is positive, the gas is regular and the heart is neat, and the heart is neat.

(Central Radio and Television General Station CCTV Network)

On the afternoon of December 28th, the Ministry of National Defense held a regular press conference, and Senior Colonel Wu Qian, Director of the Information Bureau of the Ministry of National Defense and spokesman of the Ministry of National Defense, answered questions.

Reporter:The media are concerned that China’s military diplomacy has been carried out in a vivid way this year and achieved fruitful results. Please tell us more about the situation.

Wu Qian:2023 is the first year to fully implement the spirit of the 20th Party Congress. The military diplomacy work thoroughly implements the supreme leader’s thought of strengthening the army, thoroughly implements the diplomatic thought of the supreme leader, takes the diplomacy of the head of state as the guide, takes high-level exchanges as the starting point, takes pragmatic cooperation as the key, takes the multilateral platform as the highlight, keeps the integrity, innovates and bravely moves forward, comprehensively promotes international military cooperation to improve quality and efficiency and achieve high-quality development.

First, effectively serve the overall situation of political diplomacy.Under the guidance of the diplomatic strategy of the head of state, the leaders of the Central Military Commission carried out strategic communication and deepened strategic cooperation with the defense departments and military leaders of Russia, the United States, Vietnam, Cambodia, Pakistan, South Africa and other countries. China’s armed forces have strengthened consultation and dialogue with the armed forces of relevant countries, expanded pragmatic cooperation, and actively promoted the diplomatic achievements of the head of state in the field of international military cooperation.

Second, resolutely defend national sovereignty, security and development interests.In view of the negative and erroneous remarks and acts of infringement and provocation of individual countries on the Taiwan Province issue and the South China Sea issue, while organizing rights protection actions in accordance with the law and regulations, we should effectively carry out diplomatic negotiations, promptly and forcefully refute them, show China’s solemn position, and warn and expose foreign negative trends.

The third is to actively expand foreign-related military operations.We organized and implemented 34 joint training leagues such as "North Joint -2023", "Peace Friendship -2023", "Golden Dragon -2023" and "Friendship Shield -2023" between China and Laos, expanded multi-bilateral training cooperation platforms, deepened mutual trust and cooperation with the armed forces of relevant countries, and made positive contributions to maintaining regional stability.

The fourth is to innovate and carry out multilateral diplomatic activities.Hold the 10th Beijing Xiangshan Forum, the 3rd China-Africa Peace and Security Forum, etc. to explore peaceful solutions to hot issues and create a paradigm of international security cooperation; Participate in multilateral activities such as the shangri-la dialogue Conference, the SCO Defense Ministers’ Meeting, and the ASEAN Defense Ministers’ Expansion Meeting, actively explain major ideas such as global security initiatives, and unite the consensus of the international community on peaceful cooperation.

The fifth is to serve and build a community of human destiny.The "Square Boat" hospital ship visited Kiribati, Tonga, Vanuatu, Solomon Islands, East Timor and other five countries. The PLA medical experts were stationed in Zambia, Cambodia, Laos and other countries to provide medical services to local people. The Air Force transports -20 aircraft to Afghanistan, Nepal and other countries to carry out humanitarian rescue missions; Naval ship formations went to Sudan for emergency evacuation; Actively participate in peacekeeping, escort and other actions to continuously provide public safety products to the international community.

For peace, go to the world. Guided by the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, China’s armed forces have always been committed to expanding and deepening foreign military relations, strengthening pragmatic exchanges and cooperation, and making due contributions to safeguarding world peace and promoting common development.

Wu Qian: The year 2023 marks the first year for fully implementing the guiding principles laid down at the 20th CPC National Congress. On military diplomacy, we　acted on　Xi Jinping Thought on Strengthening the Military　and Xi Jinping Thought on Diplomacy, followed the guidance of head-of-state diplomacy, took high-level exchanges　as important means, focused on practical cooperation and gave emphasis to 　multilateral　platforms. We have broken new ground, forged ahead with enterprise and fortitude, enhanced the quality and efficiency of international military cooperation and achieve　high-quality development.

First, military diplomacy served　the overall political and diplomatic objectives　of China. Under the strategic　guidance of head-of-state diplomacy, leaders of the Central Military Commission　(CMC) had strategic communication with defense and military leaders　of Russia, the United States,　Vietnam, 　Cambodia,　Pakistan, 　South Africa, etc., and deepened bilateral strategic cooperation. The Chinese military enhanced consultation and dialogue and expanded practical　cooperation　with relevant militaries to put into practice the achievements of head-of-state diplomacy.

Second, military diplomacy　resolutely safeguarded　national sovereignty, security and development　interests. In response to the negative and wrong rhetoric and infringements and provocations　made by　certain　countries on　the Taiwan　question and the South China Sea　issue, while taking actions to protect our rights in accordance with laws and regulations, the Chinese military also made diplomatic　representations, and timely refuted, warned and exposed the wrongdoings and negative moves of relevant countries, and made clear China’s positions through MND spokesperson and the media.

Thirdly, we have expanded foreign-related military operations. The PLA　organized and conducted 34　joint training, exercises　and international military games including　the China-Russia “Beibu Unity-2023”　joint exercise, the “Aman youyi-2023”　joint exercise with southeast Asian countries, the China-Cambodia “Golden Dragon 2023” joint exercise, the China-Laos　“Friendship Shield-2023” joint exercise. Through expanded bilateral and multilateral　exercises and training, the PLA has deepened　mutual trust and cooperation with the militaries of relevant countries, and played a positive role in maintaining regional　stability.

Fourthly, we have made　innovative　efforts　in multilateral diplomacy. The tenth Beijing　Xiangshan Forum and the third China-Africa Peace and Security Forum hosted by China were widely attended and welcomed. We attended mu ltilateral events including the Shangri-La　dialogue, the　Defense　Ministers’　Meeting　of the Member States of the Shanghai Cooperation Organization, the ASEAN Defense Ministers Meeting Plus (ADMM+), and actively introduced major initiatives　such as the Global Security Initiative　and promoted international consensus for peace and cooperation.

Fifthly, we have contributed to　building　a community with a shared future for mankind. The PLAN Ark Peace 　hospital　ship　visited Kiribati, Tonga, Vanuatu, Solomon Islands, and　Timor-Leste. The　Chinese military medical expert teams continued to work in Zambia, Cambodia and Laos, and provided medical service to the local people. PLA Air Force Y-20 transport aircraft carried out humanitarian relief missions to Afghanistan and Nep al.　PLA Navy vessels rushed to Sudan to evacuate Chinese nationals. The Chinese military also actively participated　in UN peacekeeping　and　vessel prote ction operations, consistently providing public security goods to the international community.

Embracing the world for peace, the Chinese military will always follow the guidance of　Xi Jinping　Thought　on　Socialism　with　Chinese　Characteristics　for a New Era, and stay committed　to expanding　and deepening　relations with foreign militaries,　strengthening　practical exchanges and cooperation, and　making　due contributions to world peace and common development.

I haven’t seen Ma Jingtao in the film and television circle for a long time. Recently, his clips in Shang Yan all over the country have always flashed on short video platforms, which shocked Yi Zhanjun.

This belly? This posture? This is Ma Jingtao? !

Is this really the dashing "Mark"? "Roaring Emperor" should not be this gesture &hellip; &hellip;

Looking at the video background, it seems to be in a small space, like a commercial activity. Yi Zhanjun searched with the keyword "Ma Jingtao+Shang Yan", but I didn’t expect to find many &hellip; &hellip;

Judging from these videos, most of Ma Jingtao’s activities are Shang Yan in the atrium of shopping malls, ribbon-cutting for commercial activities, and some are like internal gatherings. According to the description of the video producer, Ma Jingtao sometimes attends the wedding scene and frequently shakes hands with the audience under his stage. Most of the time, he will sing the theme song of the same name of Qiong Yao’s TV series "Three Lane of Plum Blossoms". Sometimes, the audience under the stage still holds flashing lights.

In these videos, Ma Jingtao is fat and slightly old, but let’s see, Ma Jingtao, born in 1962, is 60 years old this year. But the original photo with a big belly and white clothes had a great visual impact! Many people, like Yi Zhanjun, asked in their messages: Is this really Ma Jingtao?

Many people complained about his dressing style in the video, but someone replied that Mark liked this style. Yi Zhanjun remembered that in the previous Tucao Conference, he seemed to be wearing white wide-leg pants with similar styles.

Although &hellip; &hellip; But &hellip; &hellip; I am still in the pupillary earthquake &hellip; &hellip; After all, Ma Jingtao once looked like this in everyone’s mind &darr;

When I was a teenager, who didn’t let go of that "Journey to the East" on TV? Lv Dongbin is dressed in white, but also has emotional entanglements with the beautiful Bai Mudan. It’s a pity that the Millennium love robbery happened.

Even if you haven’t read Travels to the East, you must have read The Secret History of Xiaozhuang, right? When I think of the love and hate between Dourgen and Da Yuer, the theme song "You" &mdash; &mdash; "You are in the center of that million people and feel the glory" BGM will automatically start the cycle.

At that time, Ma Jingtao was hale and hearty.

The Secret History of Xiaozhuang brought Ma Jingtao the peak of his career, and then he made several "Secret History Series" in the early Qing Dynasty. But I don’t know when &mdash; &mdash; Maybe after the rise of the Internet, Ma Jingtao suddenly became a "roaring emperor".

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I have also made animation and expression packs by netizens.

These stills are all from Ma Jingtao’s early Qiong Yao drama. At that time, Ma Jingtao was also the royal male master of Qiong Yao.

How was Ma Jingtao chosen by Aunt Qiong Yao, whose eyes were high and demanding? This has to start from the beginning. Ma Jingtao, born in Taiwan Province in 1962, had many hobbies since he was a child. In high school, he also formed a band with his classmates. After graduating from college, Ma Jingtao worked as an internship assistant in a TV station. Ma Jingtao’s father works in a police agency and is very supportive of his son’s choice. With the support of his father, Ma Jingtao made seven or eight TV series, such as Hometown of Stars, in one breath from 1984 to 1988.

In 1989, Ma Jingtao starred in Spring Gone and Spring Came Back. It is this work that made Qiong Yao take a fancy to it. Qiong Yao contacted Ma Jingtao to star in his own TV series. It is said that Ma Jingtao refused at first, and then Aunt Qiong Yao fought for it several times, which led to his first Qiong Yao drama "Xueke".

Later, he filmed Qiong Yao’s Grass by the Green River, Plum Blossom Branding and Shui Yunjian, which became a big hit.

Ma Jingtao’s face is tough, his eyebrows are deep, and his eyes are full of spirits. It is easy for him to be shaped into a young man who has just entered the WTO, is frank and sincere in honest and frank, and is indomitable for love. It is suitable for Qiong Yao’s drama, and it is also suitable for Zhang Wuji in "The Dragon Slayer" which he starred in later. However, he is not as "tender" as small fresh meat now. He has a muscular feeling on his face, so he still feels gloomy, decisive and wily. This kind of depression is obvious in the Secret History of Xiaozhuang.

To be honest, such a face determines that his acting path is not narrow, and he also has acting skills. Many people mistakenly think that Qiong Yao’s opera is about shouting, crying and pure feelings, so that there is no need for acting. That’s really wrong! Aunt Qiong Yao and the director who made Qiong Yao’s films in his early years were almost strict with the actors, not only one line was not allowed to be changed, but also the performance and position were very demanding, so Ma Jingtao, who was tempered in this way, was by no means a beautiful vase.

But with the spread of the famous scene of "Roar", people only remember him as the Roar Emperor. The last impressive appearance was at the Tucao Conference in previous years. But that part is really too! Fall! Hey! Yes!

That passage was strange and the performance was inexplicable. Ma Jingtao always repeated the "roaring" scene, but because it was too sudden or too much preparation, there was no "laughing" at all, and the scene was once silent.

Later, Ma Jingtao kissed Carina Lau in the process of interaction. Carina Lau’s expression at that time was: "I was so scared &hellip; &hellip;”

Later, Ma Jingtao made a special trip to apologize on his personal account. These responses were sincere to read, but the audience also knew that he might really not be suitable for such performances and variety shows, nor for the current network ecology.

After the "embarrassing incident" of Tucao Conference, Ma Jingtao has not appeared in public view, and there are few new works, especially variety shows. Appear again, that is, those Shang Yan clips on the short video platform, and the out-of-shape photos that have been madly transmitted from the media. In this era when all the past female stars bring goods and all the past male stars are in Shang Yan, there is nothing to blame for sinking the market in Shang Yan to make money, but it is still embarrassing that a generation of "Mark" in white has become like this.

Source: Yi Zhan WeChat official account

Process Editor: U063
　

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